FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164657353> ?p ?o ?g. }

• W3164657353 endingPage "213" @default.
• W3164657353 startingPage "203" @default.
• W3164657353 abstract "<b><i>Introduction:</i></b> The skin is a major physical barrier to the environment, and thus, percutaneous delivery of active ingredients to the dermal target site faces a unique set of hurdles. The efficacy of these active ingredients is governed by their release into the underlying epidermal and dermal tissue, especially when administered topically. <b><i>Objective:</i></b> The aim of this study was to understand if different physicochemical properties influence the skin penetration of active ingredients and the depth to which they penetrate into the dermis. <b><i>Methods:</i></b> A microdialysis (MD) setup was used to compare the percutaneous penetration in superficial and deep implanted MD membranes in porcine skin. The precise MD membrane depth was determined using histological sectioning paired with microscopy, ultrasound, and a novel computed tomographic approach. <b><i>Results:</i></b> In study A, the measured depth of the superficial and deep implanted MD membranes was compared using histological sectioning, ultrasound, and computed tomography. Experimental determination of the depth up to which penetration occurs was found to be crucial to percutaneous penetration studies. In study B, the lipophilic differences of the active ingredients and its influences on the penetration was tested using hydrophilic caffeine and lipophilic LIP1 as model compounds, which have an identical molecular weight with different lipophilic characteristics. It is assumed that the lipophilic characteristics of active ingredients influence their penetration and thus governs the concentration of these molecules reaching their target site. <b><i>Conclusion:</i></b> The transdermal penetration of caffeine was found to exceed that of LIP1 through the hydrophilic environment of the dermis. Thus, the findings of this study show that the precise MD dermis localization and the physicochemical properties, such as lipophilicity, influence the penetration rate of active ingredients and lay the foundation for creating optimized transdermal delivery systems." @default.
• W3164657353 created "2021-06-07" @default.
• W3164657353 creator A5025248353 @default.
• W3164657353 creator A5038394564 @default.
• W3164657353 creator A5049856461 @default.
• W3164657353 creator A5061848625 @default.
• W3164657353 creator A5082367871 @default.
• W3164657353 date "2021-01-01" @default.
• W3164657353 modified "2023-10-18" @default.
• W3164657353 title "Comparison of Membrane Depth Determination Techniques for Active Ingredient Skin Penetration Studies Using Microdialysis" @default.
• W3164657353 cites W1561210178 @default.
• W3164657353 cites W1855866311 @default.
• W3164657353 cites W1976709832 @default.
• W3164657353 cites W1993401850 @default.
• W3164657353 cites W1995416495 @default.
• W3164657353 cites W2000258222 @default.
• W3164657353 cites W2003692529 @default.
• W3164657353 cites W2013927096 @default.
• W3164657353 cites W2015123118 @default.
• W3164657353 cites W2035625837 @default.
• W3164657353 cites W2045456307 @default.
• W3164657353 cites W2046806402 @default.
• W3164657353 cites W2048711631 @default.
• W3164657353 cites W2050505774 @default.
• W3164657353 cites W2054557776 @default.
• W3164657353 cites W2059153656 @default.
• W3164657353 cites W2059549594 @default.
• W3164657353 cites W2065227010 @default.
• W3164657353 cites W2073560903 @default.
• W3164657353 cites W2079945802 @default.
• W3164657353 cites W2089903081 @default.
• W3164657353 cites W2092672763 @default.
• W3164657353 cites W2144793644 @default.
• W3164657353 cites W2295897509 @default.
• W3164657353 cites W2532874665 @default.
• W3164657353 cites W2601730290 @default.
• W3164657353 cites W2798143720 @default.
• W3164657353 cites W2962103572 @default.
• W3164657353 cites W3089654396 @default.
• W3164657353 cites W3093478174 @default.
• W3164657353 cites W4240384253 @default.
• W3164657353 cites W46000359 @default.
• W3164657353 cites W786624263 @default.
• W3164657353 doi "https://doi.org/10.1159/000515113" @default.
• W3164657353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34023823" @default.
• W3164657353 hasPublicationYear "2021" @default.
• W3164657353 type Work @default.
• W3164657353 sameAs 3164657353 @default.
• W3164657353 citedByCount "5" @default.
• W3164657353 countsByYear W31646573532022 @default.
• W3164657353 countsByYear W31646573532023 @default.
• W3164657353 crossrefType "journal-article" @default.
• W3164657353 hasAuthorship W3164657353A5025248353 @default.
• W3164657353 hasAuthorship W3164657353A5038394564 @default.
• W3164657353 hasAuthorship W3164657353A5049856461 @default.
• W3164657353 hasAuthorship W3164657353A5061848625 @default.
• W3164657353 hasAuthorship W3164657353A5082367871 @default.
• W3164657353 hasConcept C105702510 @default.
• W3164657353 hasConcept C12554922 @default.
• W3164657353 hasConcept C127413603 @default.
• W3164657353 hasConcept C136229726 @default.
• W3164657353 hasConcept C185592680 @default.
• W3164657353 hasConcept C2777624698 @default.
• W3164657353 hasConcept C28406088 @default.
• W3164657353 hasConcept C41625074 @default.
• W3164657353 hasConcept C42475967 @default.
• W3164657353 hasConcept C45904493 @default.
• W3164657353 hasConcept C50156730 @default.
• W3164657353 hasConcept C55493867 @default.
• W3164657353 hasConcept C71924100 @default.
• W3164657353 hasConcept C80107235 @default.
• W3164657353 hasConcept C86803240 @default.
• W3164657353 hasConcept C98274493 @default.
• W3164657353 hasConceptScore W3164657353C105702510 @default.
• W3164657353 hasConceptScore W3164657353C12554922 @default.
• W3164657353 hasConceptScore W3164657353C127413603 @default.
• W3164657353 hasConceptScore W3164657353C136229726 @default.
• W3164657353 hasConceptScore W3164657353C185592680 @default.
• W3164657353 hasConceptScore W3164657353C2777624698 @default.
• W3164657353 hasConceptScore W3164657353C28406088 @default.
• W3164657353 hasConceptScore W3164657353C41625074 @default.
• W3164657353 hasConceptScore W3164657353C42475967 @default.
• W3164657353 hasConceptScore W3164657353C45904493 @default.
• W3164657353 hasConceptScore W3164657353C50156730 @default.
• W3164657353 hasConceptScore W3164657353C55493867 @default.
• W3164657353 hasConceptScore W3164657353C71924100 @default.
• W3164657353 hasConceptScore W3164657353C80107235 @default.
• W3164657353 hasConceptScore W3164657353C86803240 @default.
• W3164657353 hasConceptScore W3164657353C98274493 @default.
• W3164657353 hasIssue "4" @default.
• W3164657353 hasLocation W31646573531 @default.
• W3164657353 hasOpenAccess W3164657353 @default.
• W3164657353 hasPrimaryLocation W31646573531 @default.
• W3164657353 hasRelatedWork W1963845681 @default.
• W3164657353 hasRelatedWork W1967576533 @default.
• W3164657353 hasRelatedWork W2002788923 @default.
• W3164657353 hasRelatedWork W2023221777 @default.
• W3164657353 hasRelatedWork W2061886356 @default.

• next