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• W3164661296 abstract "BackgroundLung disease can develop within the first year of life in infants with cystic fibrosis (CF). However, the frequency and severity of respiratory symptoms in infancy are not known.MethodsWe assessed respiratory symptoms in 50 infants with CF and 50 healthy matched controls from two prospective birth cohort studies. Respiratory symptoms and respiratory rate were documented by standardized weekly interviews throughout the first year. Infants performed multiple breath washout in the first weeks of life.ResultsWe analyzed 4552 data points (2217 in CF). Respiratory symptoms (either mild or severe) were not more frequent in infants with CF (OR:1.1;95% CI:[0.76, 1.59]; p=0.6). Higher lung clearance index and higher respiratory rate in infants with CF were not associated with respiratory symptoms.ConclusionsWe found no difference in respiratory symptoms between healthy and CF infants. These data indicate that early CF lung disease may not be captured by clinical presentation alone." @default.
• W3164661296 created "2021-06-07" @default.
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• W3164661296 date "2021-11-01" @default.
• W3164661296 modified "2023-09-23" @default.
• W3164661296 title "Respiratory symptoms do not reflect functional impairment in early CF lung disease" @default.
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• W3164661296 doi "https://doi.org/10.1016/j.jcf.2021.04.006" @default.
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