Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164672211> ?p ?o ?g. }
- W3164672211 endingPage "954" @default.
- W3164672211 startingPage "954" @default.
- W3164672211 abstract "Preparation of nanocrystal formulations by wet media milling and spray-drying is a reliable technique to enhance dissolution and ameliorate absorption limitations of poorly soluble BCS II drugs. However, when thermosensitive compositions are dried at high temperatures, the risks of particle aggregation and thermal degradation must be considered. The present study investigates the effects of nanosuspension formulation variables when performing the spray drying process at equidistant temperatures above and below the melting point. Towards this purpose, Fenofibrate is exploited as a model drug of unfavorable pharmacokinetic profile and low melting point (79–82 °C), properties that render thermal processing a nontrivial task. Rationalizing the system’s behavior by combining molecular simulations with QbD methodology, the preparation of stable nanocrystals can be “steered” in order to avoid undesirable melting. The statistically resolved operational conditions showed that Fenofibrate Critical Quality Attribute–compliant nanosuspensions i.e., bearing hydrodynamic diameter and ζ-potential of 887 nm and −16.49 mV, respectively, were obtained by wet milling drug to Pharmacoat and mannitol weighted optimum ratios of 4.075% and 0.75%, after spray drying at the desired temperature of 77 °C. In conclusion, we present a quality assurance methodology of nano-comminution generally applicable for thermo-labile BCS II drugs." @default.
- W3164672211 created "2021-06-07" @default.
- W3164672211 creator A5011028952 @default.
- W3164672211 creator A5056170905 @default.
- W3164672211 creator A5057325348 @default.
- W3164672211 creator A5064978732 @default.
- W3164672211 creator A5068610357 @default.
- W3164672211 date "2021-05-27" @default.
- W3164672211 modified "2023-09-26" @default.
- W3164672211 title "Development of a Nanocrystal Formulation of a Low Melting Point API Following a Quality by Design Approach" @default.
- W3164672211 cites W1853947313 @default.
- W3164672211 cites W1963651292 @default.
- W3164672211 cites W1971725505 @default.
- W3164672211 cites W1984246568 @default.
- W3164672211 cites W1986744233 @default.
- W3164672211 cites W1993772148 @default.
- W3164672211 cites W2011172280 @default.
- W3164672211 cites W2021130493 @default.
- W3164672211 cites W2022950330 @default.
- W3164672211 cites W2023555126 @default.
- W3164672211 cites W2030951340 @default.
- W3164672211 cites W2032755527 @default.
- W3164672211 cites W2038643971 @default.
- W3164672211 cites W2057502998 @default.
- W3164672211 cites W2062143336 @default.
- W3164672211 cites W2062346329 @default.
- W3164672211 cites W2063950322 @default.
- W3164672211 cites W2084733373 @default.
- W3164672211 cites W2085822586 @default.
- W3164672211 cites W2086945873 @default.
- W3164672211 cites W2115972494 @default.
- W3164672211 cites W2125621156 @default.
- W3164672211 cites W2138484278 @default.
- W3164672211 cites W2202134586 @default.
- W3164672211 cites W2217400778 @default.
- W3164672211 cites W2250686278 @default.
- W3164672211 cites W2319902168 @default.
- W3164672211 cites W2788159681 @default.
- W3164672211 cites W2913692023 @default.
- W3164672211 cites W3020313387 @default.
- W3164672211 cites W3024130453 @default.
- W3164672211 cites W3027847861 @default.
- W3164672211 cites W3039629968 @default.
- W3164672211 cites W3093450930 @default.
- W3164672211 cites W3151960558 @default.
- W3164672211 cites W3156402140 @default.
- W3164672211 cites W4244894666 @default.
- W3164672211 doi "https://doi.org/10.3390/pr9060954" @default.
- W3164672211 hasPublicationYear "2021" @default.
- W3164672211 type Work @default.
- W3164672211 sameAs 3164672211 @default.
- W3164672211 citedByCount "6" @default.
- W3164672211 countsByYear W31646722112021 @default.
- W3164672211 countsByYear W31646722112022 @default.
- W3164672211 countsByYear W31646722112023 @default.
- W3164672211 crossrefType "journal-article" @default.
- W3164672211 hasAuthorship W3164672211A5011028952 @default.
- W3164672211 hasAuthorship W3164672211A5056170905 @default.
- W3164672211 hasAuthorship W3164672211A5057325348 @default.
- W3164672211 hasAuthorship W3164672211A5064978732 @default.
- W3164672211 hasAuthorship W3164672211A5068610357 @default.
- W3164672211 hasBestOaLocation W31646722111 @default.
- W3164672211 hasConcept C127413603 @default.
- W3164672211 hasConcept C134018914 @default.
- W3164672211 hasConcept C13530604 @default.
- W3164672211 hasConcept C159985019 @default.
- W3164672211 hasConcept C171250308 @default.
- W3164672211 hasConcept C175854130 @default.
- W3164672211 hasConcept C187530423 @default.
- W3164672211 hasConcept C192562407 @default.
- W3164672211 hasConcept C21880701 @default.
- W3164672211 hasConcept C2778110834 @default.
- W3164672211 hasConcept C2780449318 @default.
- W3164672211 hasConcept C42360764 @default.
- W3164672211 hasConcept C71924100 @default.
- W3164672211 hasConcept C88380143 @default.
- W3164672211 hasConceptScore W3164672211C127413603 @default.
- W3164672211 hasConceptScore W3164672211C134018914 @default.
- W3164672211 hasConceptScore W3164672211C13530604 @default.
- W3164672211 hasConceptScore W3164672211C159985019 @default.
- W3164672211 hasConceptScore W3164672211C171250308 @default.
- W3164672211 hasConceptScore W3164672211C175854130 @default.
- W3164672211 hasConceptScore W3164672211C187530423 @default.
- W3164672211 hasConceptScore W3164672211C192562407 @default.
- W3164672211 hasConceptScore W3164672211C21880701 @default.
- W3164672211 hasConceptScore W3164672211C2778110834 @default.
- W3164672211 hasConceptScore W3164672211C2780449318 @default.
- W3164672211 hasConceptScore W3164672211C42360764 @default.
- W3164672211 hasConceptScore W3164672211C71924100 @default.
- W3164672211 hasConceptScore W3164672211C88380143 @default.
- W3164672211 hasIssue "6" @default.
- W3164672211 hasLocation W31646722111 @default.
- W3164672211 hasOpenAccess W3164672211 @default.
- W3164672211 hasPrimaryLocation W31646722111 @default.
- W3164672211 hasRelatedWork W1020487878 @default.
- W3164672211 hasRelatedWork W1494267289 @default.
- W3164672211 hasRelatedWork W1502789044 @default.
- W3164672211 hasRelatedWork W1983406611 @default.