Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164697392> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W3164697392 endingPage "237" @default.
- W3164697392 startingPage "237" @default.
- W3164697392 abstract "Parkinsonism is a rare complication of non-germinomatous germ cell tumors (NGGCTs) arising from the pineal region.We describe a 23-year-old man who presented with Parinaud syndrome, fatigue, and hypersomnia that were caused by a pineal region NGGCT with yolk sac component and an initial α-fetoprotein (AFP) of 1011.0 ng/ml. MRI revealed that the tumor was causing 10 mm of midline shift and compressing the cerebral aqueduct, the left thalamus, and the midbrain. Obstructive hydrocephalus was relieved by ventriculoperitoneal shunting. Six cycles of induction chemotherapy with ifosfamide, carboplatin, and etoposide reduced tumor size and decreased AFP levels in both serum and cerebrospinal fluid. Following the first cycle, the patient developed asymmetric, bilateral Parkinsonism consisting of bradykinesia, bradyphrenia, facial hypomimia, drooling, and dysphagia. Levodopa, amantadine, and methylphenidate were administered and resulted in symptom improvement. Second look neurosurgery revealed residual yolk sac tumor and a second induction regimen of gemcitabine, paclitaxel, and oxaliplatin was administered for rising AFP. The patient eventually received an autologous bone marrow transplant using a regimen of high-dose carboplatin, thiotepa, and etoposide with concomitant colony-stimulating factor and romiplostim support followed by consolidative proton craniospinal radiotherapy. Posttreatment head MRI showed that no evidence of tumor growth and serum AFP was within normal limits. His Parkinsonism eventually resolved and he was weaned off all dopaminergic drugs.Bilateral Parkinsonism from NGGCT in this patient is probably caused by pressure on nigrostriatal tracts, substantia nigra, or both. The Parkinsonian symptoms can be reversed by aggressive treatment of the tumor and administration of dopaminergic drugs." @default.
- W3164697392 created "2021-06-07" @default.
- W3164697392 creator A5009288420 @default.
- W3164697392 creator A5017743060 @default.
- W3164697392 creator A5031890333 @default.
- W3164697392 creator A5045425111 @default.
- W3164697392 creator A5047993679 @default.
- W3164697392 creator A5055848888 @default.
- W3164697392 creator A5059686122 @default.
- W3164697392 creator A5067994799 @default.
- W3164697392 creator A5084499169 @default.
- W3164697392 date "2021-05-25" @default.
- W3164697392 modified "2023-09-23" @default.
- W3164697392 title "Parkinsonism reversed from treatment of pineal non-germinomatous germ cell tumor" @default.
- W3164697392 cites W1604647162 @default.
- W3164697392 cites W1982061583 @default.
- W3164697392 cites W1990115297 @default.
- W3164697392 cites W2064085713 @default.
- W3164697392 cites W2101159300 @default.
- W3164697392 cites W2120457564 @default.
- W3164697392 cites W2139343352 @default.
- W3164697392 cites W2144589754 @default.
- W3164697392 cites W2149296823 @default.
- W3164697392 cites W2727345885 @default.
- W3164697392 cites W2793219850 @default.
- W3164697392 cites W2940999501 @default.
- W3164697392 cites W2982257800 @default.
- W3164697392 cites W3205589153 @default.
- W3164697392 doi "https://doi.org/10.25259/sni_595_2020" @default.
- W3164697392 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8248242" @default.
- W3164697392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34221568" @default.
- W3164697392 hasPublicationYear "2021" @default.
- W3164697392 type Work @default.
- W3164697392 sameAs 3164697392 @default.
- W3164697392 citedByCount "0" @default.
- W3164697392 crossrefType "journal-article" @default.
- W3164697392 hasAuthorship W3164697392A5009288420 @default.
- W3164697392 hasAuthorship W3164697392A5017743060 @default.
- W3164697392 hasAuthorship W3164697392A5031890333 @default.
- W3164697392 hasAuthorship W3164697392A5045425111 @default.
- W3164697392 hasAuthorship W3164697392A5047993679 @default.
- W3164697392 hasAuthorship W3164697392A5055848888 @default.
- W3164697392 hasAuthorship W3164697392A5059686122 @default.
- W3164697392 hasAuthorship W3164697392A5067994799 @default.
- W3164697392 hasAuthorship W3164697392A5084499169 @default.
- W3164697392 hasBestOaLocation W31646973921 @default.
- W3164697392 hasConcept C126322002 @default.
- W3164697392 hasConcept C137183658 @default.
- W3164697392 hasConcept C141071460 @default.
- W3164697392 hasConcept C2776525014 @default.
- W3164697392 hasConcept C2776694085 @default.
- W3164697392 hasConcept C2778119113 @default.
- W3164697392 hasConcept C2778239845 @default.
- W3164697392 hasConcept C2778895204 @default.
- W3164697392 hasConcept C2779134260 @default.
- W3164697392 hasConcept C2780938664 @default.
- W3164697392 hasConcept C2781451048 @default.
- W3164697392 hasConcept C42219234 @default.
- W3164697392 hasConcept C509974204 @default.
- W3164697392 hasConcept C513476851 @default.
- W3164697392 hasConcept C71924100 @default.
- W3164697392 hasConceptScore W3164697392C126322002 @default.
- W3164697392 hasConceptScore W3164697392C137183658 @default.
- W3164697392 hasConceptScore W3164697392C141071460 @default.
- W3164697392 hasConceptScore W3164697392C2776525014 @default.
- W3164697392 hasConceptScore W3164697392C2776694085 @default.
- W3164697392 hasConceptScore W3164697392C2778119113 @default.
- W3164697392 hasConceptScore W3164697392C2778239845 @default.
- W3164697392 hasConceptScore W3164697392C2778895204 @default.
- W3164697392 hasConceptScore W3164697392C2779134260 @default.
- W3164697392 hasConceptScore W3164697392C2780938664 @default.
- W3164697392 hasConceptScore W3164697392C2781451048 @default.
- W3164697392 hasConceptScore W3164697392C42219234 @default.
- W3164697392 hasConceptScore W3164697392C509974204 @default.
- W3164697392 hasConceptScore W3164697392C513476851 @default.
- W3164697392 hasConceptScore W3164697392C71924100 @default.
- W3164697392 hasLocation W31646973921 @default.
- W3164697392 hasLocation W31646973922 @default.
- W3164697392 hasLocation W31646973923 @default.
- W3164697392 hasOpenAccess W3164697392 @default.
- W3164697392 hasPrimaryLocation W31646973921 @default.
- W3164697392 hasRelatedWork W2029688276 @default.
- W3164697392 hasRelatedWork W2049074931 @default.
- W3164697392 hasRelatedWork W2068859133 @default.
- W3164697392 hasRelatedWork W2070516803 @default.
- W3164697392 hasRelatedWork W2118270234 @default.
- W3164697392 hasRelatedWork W2142316271 @default.
- W3164697392 hasRelatedWork W2280834703 @default.
- W3164697392 hasRelatedWork W2348495938 @default.
- W3164697392 hasRelatedWork W2789166760 @default.
- W3164697392 hasRelatedWork W2133000900 @default.
- W3164697392 hasVolume "12" @default.
- W3164697392 isParatext "false" @default.
- W3164697392 isRetracted "false" @default.
- W3164697392 magId "3164697392" @default.
- W3164697392 workType "article" @default.