FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164714928> ?p ?o ?g. }

• W3164714928 endingPage "1357" @default.
• W3164714928 startingPage "1356.2" @default.
• W3164714928 abstract "Background: Catastrophic antiphospholipid syndrome (CAPS) is a severe autoimmune condition, characterized by multiorgan failure due to thromboses and/or hemorrhage. Concurrent HSV/VZV infection is an exceedingly rare event, occurring mostly in immunocompromised patients. Herein, we report the first case of CAPS triggered by concurrent HSV/VZV infection, manifesting with zosteriform rash and haemorrhages at multiple sites. Objectives: To describe a case of CAPS provoked by concurrent HSV/VZV infection, manifesting with zosteriform rash and haemorrhages at multiple sites. Methods: A 36-year-old male, with a history of antiphospholipid syndrome (APS) presented with a 5-day history of epigastric pain, associated with fever, hematuria, rash and swelling in bilateral ears. Past medical history was remarkable for APS, based on 4 episodes of DVT/PE and triple positive antiphospholipid antibodies, on chronic well-maintained warfarin anticoagulation. On examination, a purpuric rash was evident on the right side of the neck as well as on both ears, consistent with a C3 dermatomal distribution (Figure 1). Laboratory studies revealed anemia, thrombocytopenia and acute kidney injury. Figure 1. Results: A full-body CT scan demonstrated the presence of multifocal lymphadenopathy, alveolar infiltrates suggestive of diffuse alveolar haemorrhage, and haemorrhage in both kidneys and the left adrenal gland; anticoagulation was held, despite the INR being within the patient’s baseline therapeutic levels. He was admitted with a working diagnosis of CAPS and possible zoster infection. Appropriate immunologic workup was requested. He was prescribed intravenous acyclovir, antibiotics, pulse dose of glucocorticoids, and IVIG. Bronchoscopy with bronchoalveolar lavage revealed the presence of haemosiderin-laden macrophages. The rash regressed, and the patients’ condition improved. He was discharged with glucocorticoid tapering regimen, hydroxychloroquine, aspirin and warfarin. Antibody titers were taken prior to IVIG administration at presentation, and at 4 weeks. High VZV IgG titers found at presentation regressed over four times on follow-up. Furthermore, at 4 weeks the patient had developed IgM antibodies against both VZV and HSV. These findings confirmed a concurrent infection. Conclusion: This is the first report of coexisting HSV/VZV infection associated with CAPS. A literature review identified a total of 28 patients with coexisting HSV/VZV infection, whereas only one case of CAPS triggered by HSV was identified 1 . This case illustrates that concurrent infection can occur in the absence of immunosuppressive therapy in patients with APS, serving as a trigger for hemorrhagic CAPS. Simultaneous treatment with antiviral against herpesviruses, glucocorticoids and IVIG may mitigate the inflammatory cascade associated with CAPS. References: [1]Catoggio C, Alvarez-Uría A, Fernandez PL, Cervera R, Espinosa G. Catastrophic antiphospholipid syndrome triggered by fulminant disseminated herpes simplex infection in a patient with systemic lupus erythematosus. Lupus. 2012 Oct;21(12):1359-61. Disclosure of Interests: None declared." @default.
• W3164714928 created "2021-06-07" @default.
• W3164714928 creator A5009484606 @default.
• W3164714928 creator A5014889026 @default.
• W3164714928 creator A5036079806 @default.
• W3164714928 creator A5085320137 @default.
• W3164714928 creator A5089078984 @default.
• W3164714928 date "2021-05-19" @default.
• W3164714928 modified "2023-09-26" @default.
• W3164714928 title "AB0647 CATASTROPHIC ANTIPHOSPHOLIPID SYNDROME TRIGGERED BY CONCURRENT VZV AND HSV INFECTION. A CASE REPORT" @default.
• W3164714928 doi "https://doi.org/10.1136/annrheumdis-2021-eular.470" @default.
• W3164714928 hasPublicationYear "2021" @default.
• W3164714928 type Work @default.
• W3164714928 sameAs 3164714928 @default.
• W3164714928 citedByCount "0" @default.
• W3164714928 crossrefType "journal-article" @default.
• W3164714928 hasAuthorship W3164714928A5009484606 @default.
• W3164714928 hasAuthorship W3164714928A5014889026 @default.
• W3164714928 hasAuthorship W3164714928A5036079806 @default.
• W3164714928 hasAuthorship W3164714928A5085320137 @default.
• W3164714928 hasAuthorship W3164714928A5089078984 @default.
• W3164714928 hasBestOaLocation W31647149281 @default.
• W3164714928 hasConcept C126322002 @default.
• W3164714928 hasConcept C141071460 @default.
• W3164714928 hasConcept C16005928 @default.
• W3164714928 hasConcept C206179267 @default.
• W3164714928 hasConcept C2776874634 @default.
• W3164714928 hasConcept C2777247642 @default.
• W3164714928 hasConcept C2778570526 @default.
• W3164714928 hasConcept C2779134260 @default.
• W3164714928 hasConcept C2779655305 @default.
• W3164714928 hasConcept C2780505380 @default.
• W3164714928 hasConcept C2780868729 @default.
• W3164714928 hasConcept C2781179581 @default.
• W3164714928 hasConcept C71924100 @default.
• W3164714928 hasConceptScore W3164714928C126322002 @default.
• W3164714928 hasConceptScore W3164714928C141071460 @default.
• W3164714928 hasConceptScore W3164714928C16005928 @default.
• W3164714928 hasConceptScore W3164714928C206179267 @default.
• W3164714928 hasConceptScore W3164714928C2776874634 @default.
• W3164714928 hasConceptScore W3164714928C2777247642 @default.
• W3164714928 hasConceptScore W3164714928C2778570526 @default.
• W3164714928 hasConceptScore W3164714928C2779134260 @default.
• W3164714928 hasConceptScore W3164714928C2779655305 @default.
• W3164714928 hasConceptScore W3164714928C2780505380 @default.
• W3164714928 hasConceptScore W3164714928C2780868729 @default.
• W3164714928 hasConceptScore W3164714928C2781179581 @default.
• W3164714928 hasConceptScore W3164714928C71924100 @default.
• W3164714928 hasIssue "Suppl 1" @default.
• W3164714928 hasLocation W31647149281 @default.
• W3164714928 hasOpenAccess W3164714928 @default.
• W3164714928 hasPrimaryLocation W31647149281 @default.
• W3164714928 hasRelatedWork W135199515 @default.
• W3164714928 hasRelatedWork W1965190362 @default.
• W3164714928 hasRelatedWork W2061943507 @default.
• W3164714928 hasRelatedWork W2078056994 @default.
• W3164714928 hasRelatedWork W2408964891 @default.
• W3164714928 hasRelatedWork W2484196320 @default.
• W3164714928 hasRelatedWork W3004565659 @default.
• W3164714928 hasRelatedWork W3139133643 @default.
• W3164714928 hasRelatedWork W3164714928 @default.
• W3164714928 hasRelatedWork W3176937688 @default.
• W3164714928 hasVolume "80" @default.
• W3164714928 isParatext "false" @default.
• W3164714928 isRetracted "false" @default.
• W3164714928 magId "3164714928" @default.
• W3164714928 workType "article" @default.