Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164753005> ?p ?o ?g. }
- W3164753005 endingPage "e500" @default.
- W3164753005 startingPage "e489" @default.
- W3164753005 abstract "To determine whether microRNAs (miRs) are elevated in the plasma of individuals with the inherited peripheral neuropathy Charcot-Marie-Tooth disease type 1A (CMT1A), miR profiling was employed to compare control and CMT1A plasma.We performed a screen of CMT1A and control plasma samples to identify miRs that are elevated in CMT1A using next-generation sequencing, followed by validation of selected miRs by quantitative PCR, and correlation with protein biomarkers and clinical data: Rasch-modified CMT Examination and Neuropathy Scores, ulnar compound muscle action potentials, and motor nerve conduction velocities.After an initial pilot screen, a broader screen confirmed elevated levels of several muscle-associated miRNAs (miR1, -133a, -133b, and -206, known as myomiRs) along with a set of miRs that are highly expressed in Schwann cells of peripheral nerve. Comparison to other candidate biomarkers for CMT1A (e.g., neurofilament light) measured on the same sample set shows a comparable elevation of several miRs (e.g., miR133a, -206, -223) and ability to discriminate cases from controls. Neurofilament light levels were most highly correlated with miR133a. In addition, the putative Schwann cell miRs (e.g., miR223, -199a, -328, -409, -431) correlate with the recently described transmembrane protease serine 5 (TMPRSS5) protein biomarker that is most highly expressed in Schwann cells and also elevated in CMT1A plasma.These studies identify a set of miRs that are candidate biomarkers for clinical trials in CMT1A. Some of the miRs may reflect Schwann cell processes that underlie the pathogenesis of the disease.This study provides Class III evidence that a set of plasma miRs are elevated in patients with CMT1A." @default.
- W3164753005 created "2021-06-07" @default.
- W3164753005 creator A5001878666 @default.
- W3164753005 creator A5007528209 @default.
- W3164753005 creator A5009404110 @default.
- W3164753005 creator A5012730373 @default.
- W3164753005 creator A5022367623 @default.
- W3164753005 creator A5023365864 @default.
- W3164753005 creator A5024191252 @default.
- W3164753005 creator A5038002065 @default.
- W3164753005 creator A5038709106 @default.
- W3164753005 creator A5038770040 @default.
- W3164753005 creator A5058248605 @default.
- W3164753005 creator A5063761087 @default.
- W3164753005 creator A5064539963 @default.
- W3164753005 creator A5077519954 @default.
- W3164753005 creator A5087253952 @default.
- W3164753005 creator A5087519503 @default.
- W3164753005 date "2021-08-03" @default.
- W3164753005 modified "2023-09-30" @default.
- W3164753005 title "MicroRNAs as Biomarkers of Charcot-Marie-Tooth Disease Type 1A" @default.
- W3164753005 cites W1965375903 @default.
- W3164753005 cites W1971770312 @default.
- W3164753005 cites W1973224467 @default.
- W3164753005 cites W1989023345 @default.
- W3164753005 cites W1995985897 @default.
- W3164753005 cites W2001768554 @default.
- W3164753005 cites W2059771026 @default.
- W3164753005 cites W2062821199 @default.
- W3164753005 cites W2067432992 @default.
- W3164753005 cites W2094895072 @default.
- W3164753005 cites W2102244428 @default.
- W3164753005 cites W2103079859 @default.
- W3164753005 cites W2103256993 @default.
- W3164753005 cites W2107206481 @default.
- W3164753005 cites W2121807254 @default.
- W3164753005 cites W2125093810 @default.
- W3164753005 cites W2126225675 @default.
- W3164753005 cites W2126779593 @default.
- W3164753005 cites W2137894294 @default.
- W3164753005 cites W2140309031 @default.
- W3164753005 cites W2171855162 @default.
- W3164753005 cites W2174734928 @default.
- W3164753005 cites W2189787157 @default.
- W3164753005 cites W2198556320 @default.
- W3164753005 cites W2267328205 @default.
- W3164753005 cites W2461210998 @default.
- W3164753005 cites W2465265719 @default.
- W3164753005 cites W2465463861 @default.
- W3164753005 cites W2473787591 @default.
- W3164753005 cites W2732721623 @default.
- W3164753005 cites W2752026452 @default.
- W3164753005 cites W2756135786 @default.
- W3164753005 cites W2769235330 @default.
- W3164753005 cites W2774391451 @default.
- W3164753005 cites W2783746308 @default.
- W3164753005 cites W2798132022 @default.
- W3164753005 cites W2808800485 @default.
- W3164753005 cites W2886211838 @default.
- W3164753005 cites W2903978398 @default.
- W3164753005 cites W2933505114 @default.
- W3164753005 cites W2945249473 @default.
- W3164753005 cites W2955450231 @default.
- W3164753005 cites W2967091052 @default.
- W3164753005 cites W2977879691 @default.
- W3164753005 cites W2978462615 @default.
- W3164753005 cites W2995102752 @default.
- W3164753005 cites W3006665308 @default.
- W3164753005 cites W3036981985 @default.
- W3164753005 cites W4255156463 @default.
- W3164753005 doi "https://doi.org/10.1212/wnl.0000000000012266" @default.
- W3164753005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8356381" @default.
- W3164753005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34031204" @default.
- W3164753005 hasPublicationYear "2021" @default.
- W3164753005 type Work @default.
- W3164753005 sameAs 3164753005 @default.
- W3164753005 citedByCount "11" @default.
- W3164753005 countsByYear W31647530052021 @default.
- W3164753005 countsByYear W31647530052022 @default.
- W3164753005 countsByYear W31647530052023 @default.
- W3164753005 crossrefType "journal-article" @default.
- W3164753005 hasAuthorship W3164753005A5001878666 @default.
- W3164753005 hasAuthorship W3164753005A5007528209 @default.
- W3164753005 hasAuthorship W3164753005A5009404110 @default.
- W3164753005 hasAuthorship W3164753005A5012730373 @default.
- W3164753005 hasAuthorship W3164753005A5022367623 @default.
- W3164753005 hasAuthorship W3164753005A5023365864 @default.
- W3164753005 hasAuthorship W3164753005A5024191252 @default.
- W3164753005 hasAuthorship W3164753005A5038002065 @default.
- W3164753005 hasAuthorship W3164753005A5038709106 @default.
- W3164753005 hasAuthorship W3164753005A5038770040 @default.
- W3164753005 hasAuthorship W3164753005A5058248605 @default.
- W3164753005 hasAuthorship W3164753005A5063761087 @default.
- W3164753005 hasAuthorship W3164753005A5064539963 @default.
- W3164753005 hasAuthorship W3164753005A5077519954 @default.
- W3164753005 hasAuthorship W3164753005A5087253952 @default.
- W3164753005 hasAuthorship W3164753005A5087519503 @default.
- W3164753005 hasBestOaLocation W31647530052 @default.