FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164755064> ?p ?o ?g. }

• W3164755064 endingPage "4228" @default.
• W3164755064 startingPage "4214" @default.
• W3164755064 abstract "Abstract Head and neck squamous cell carcinoma (HNSCC) is often being diagnosed at an advanced stage, conferring a poor prognosis. The probability of local tumor control after radiotherapy depends on the eradication of cancer stem cells (CSCs) with activated DNA repair. This study provides evidence that the CSC-related transcription factor Oct4 contributes to HNSCC radioresistance by regulating DNA damage response and the CSC phenotype. Knockdown of Oct4 A isoform reduced self-renewal capacity in HNSCC and led to partial tumor cell radiosensitization caused by transcriptional downregulation of the cell cycle checkpoint kinases CHK1 and WEE1 and homologous recombination (HR) repair genes PSMC3IP and RAD54L. Besides, PARP inhibition with Olaparib selectively radiosensitized Oct4 A knockout, but not wild-type HNSCC cells. This finding links Oct4 A to the HR-mediated DNA repair mechanisms. In turn, knockdown of PSMC3IP and RAD54L reduced the HNSCC self-renewal capacity and clonogenic cell survival after irradiation, suggesting the interplay between DNA repair and the CSC phenotype. Similar to the effect of Oct4 knockdown, overexpression of Oct4 also resulted in significant HNSCC radiosensitization and increased DNA damage, suggesting that Oct4-dependent regulation of DNA repair depends on its fine-tuned expression. In line with this observation, HNSCC patients with high and low nuclear Oct4 expression at the invasive tumor front exhibited better loco-regional tumor control after postoperative radio(chemo)therapy compared to the intermediate expression subgroup. Thus, we found that the Oct4-driven transcriptional program plays a critical role in regulating HNSCC radioresistance, and a combination of radiotherapy with PARP inhibitors may induce synthetic lethality in Oct4-deregulated tumors." @default.
• W3164755064 created "2021-06-07" @default.
• W3164755064 creator A5023761317 @default.
• W3164755064 creator A5031159770 @default.
• W3164755064 creator A5038221503 @default.
• W3164755064 creator A5039276843 @default.
• W3164755064 creator A5041143102 @default.
• W3164755064 creator A5048099568 @default.
• W3164755064 creator A5056713085 @default.
• W3164755064 creator A5061093685 @default.
• W3164755064 creator A5067761254 @default.
• W3164755064 creator A5083101824 @default.
• W3164755064 creator A5089075468 @default.
• W3164755064 date "2021-06-02" @default.
• W3164755064 modified "2023-10-16" @default.
• W3164755064 title "Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L" @default.
• W3164755064 cites W109776568 @default.
• W3164755064 cites W1548598561 @default.
• W3164755064 cites W1608762409 @default.
• W3164755064 cites W1845572554 @default.
• W3164755064 cites W1990099538 @default.
• W3164755064 cites W1990956554 @default.
• W3164755064 cites W1992199366 @default.
• W3164755064 cites W1992676863 @default.
• W3164755064 cites W1994414478 @default.
• W3164755064 cites W1997046409 @default.
• W3164755064 cites W1997203401 @default.
• W3164755064 cites W2004032403 @default.
• W3164755064 cites W2004878973 @default.
• W3164755064 cites W2009007206 @default.
• W3164755064 cites W2010608530 @default.
• W3164755064 cites W2012801703 @default.
• W3164755064 cites W2014482764 @default.
• W3164755064 cites W2020262790 @default.
• W3164755064 cites W2023832667 @default.
• W3164755064 cites W2024145520 @default.
• W3164755064 cites W2029304297 @default.
• W3164755064 cites W2032762013 @default.
• W3164755064 cites W2072693879 @default.
• W3164755064 cites W2077436902 @default.
• W3164755064 cites W2078753112 @default.
• W3164755064 cites W2081116295 @default.
• W3164755064 cites W2091030022 @default.
• W3164755064 cites W2096768863 @default.
• W3164755064 cites W2102552859 @default.
• W3164755064 cites W2110664940 @default.
• W3164755064 cites W2114119309 @default.
• W3164755064 cites W2117332972 @default.
• W3164755064 cites W2117502397 @default.
• W3164755064 cites W2124891284 @default.
• W3164755064 cites W2125972940 @default.
• W3164755064 cites W2144108148 @default.
• W3164755064 cites W2148110430 @default.
• W3164755064 cites W2148474950 @default.
• W3164755064 cites W2148818765 @default.
• W3164755064 cites W2149795092 @default.
• W3164755064 cites W2235025686 @default.
• W3164755064 cites W2258673083 @default.
• W3164755064 cites W2290100062 @default.
• W3164755064 cites W244067726 @default.
• W3164755064 cites W2558300345 @default.
• W3164755064 cites W2605017029 @default.
• W3164755064 cites W2611297475 @default.
• W3164755064 cites W2793226176 @default.
• W3164755064 cites W2799740499 @default.
• W3164755064 cites W2802173909 @default.
• W3164755064 cites W2803472914 @default.
• W3164755064 cites W2860983699 @default.
• W3164755064 cites W2886541635 @default.
• W3164755064 cites W2907345403 @default.
• W3164755064 cites W2909452265 @default.
• W3164755064 cites W2912008463 @default.
• W3164755064 cites W2943830014 @default.
• W3164755064 cites W2946130721 @default.
• W3164755064 cites W2952051913 @default.
• W3164755064 cites W2969870070 @default.
• W3164755064 cites W2971578135 @default.
• W3164755064 cites W2989827347 @default.
• W3164755064 cites W2997271239 @default.
• W3164755064 cites W3016423154 @default.
• W3164755064 cites W3021755237 @default.
• W3164755064 cites W3032979845 @default.
• W3164755064 doi "https://doi.org/10.1038/s41388-021-01842-1" @default.
• W3164755064 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8211562" @default.
• W3164755064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34079088" @default.
• W3164755064 hasPublicationYear "2021" @default.
• W3164755064 type Work @default.
• W3164755064 sameAs 3164755064 @default.
• W3164755064 citedByCount "20" @default.
• W3164755064 countsByYear W31647550642021 @default.
• W3164755064 countsByYear W31647550642022 @default.
• W3164755064 countsByYear W31647550642023 @default.
• W3164755064 crossrefType "journal-article" @default.
• W3164755064 hasAuthorship W3164755064A5023761317 @default.
• W3164755064 hasAuthorship W3164755064A5031159770 @default.
• W3164755064 hasAuthorship W3164755064A5038221503 @default.
• W3164755064 hasAuthorship W3164755064A5039276843 @default.
• W3164755064 hasAuthorship W3164755064A5041143102 @default.

• next