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- W3164778492 abstract "We previously reported the application of the aryloxy triester phosphoramidate prodrug technology to the phosphoantigen (E)-4-hydroxybut-2-enyl phosphate (HMBP). Although these prodrugs exhibited potent activation of Vγ9/Vδ2 T‐cell immune responses, their stability was low due to the rapid cleavage of the -O-P- bond. To address this, we herein report the application of the same prodrug strategy to two HMBP phosphonates, which have stable -CH2-P- or -CF2-P- bonds. These HMBP phosphonate prodrugs, phosphonamidates, exhibited excellent serum stability and potent activation of Vgama9/Vdelta2 T‐cells making them attractive compounds for further development as potential immunotherapeutics." @default.
- W3164778492 created "2021-06-07" @default.
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- W3164778492 date "2018-07-06" @default.
- W3164778492 modified "2023-09-23" @default.
- W3164778492 title "Aryloxy Triester Phosphonamidates of Phosphoantigens Exhibit Favorable Stability and Potent Activation of Vγ9/Vδ2 T‐Cells" @default.
- W3164778492 doi "https://doi.org/10.26434/chemrxiv.6755033.v1" @default.
- W3164778492 hasPublicationYear "2018" @default.
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