Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164796831> ?p ?o ?g. }
- W3164796831 endingPage "717" @default.
- W3164796831 startingPage "706" @default.
- W3164796831 abstract "Current antiviral therapies, such as pegylated interferon-α and nucleos(t)ide analogues, effectively improve the quality of life of patients with chronic hepatitis B. However, they can only control the infection rather than curing infected hepatocytes. Complete HBV cure is hampered by the lack of therapies that can directly affect the viral minichromosome (in the form of covalently closed circular DNA [cccDNA]). Approaches currently under investigation in early clinical trials are aimed at achieving a functional cure, defined as the loss of HBsAg and undetectable HBV DNA levels in serum. However, achieving a complete HBV cure requires therapies that can directly target the cccDNA pool, either via degradation, lethal mutations or functional silencing. In this review, we discuss cutting-edge technologies that could lead to non-cytolytic direct cccDNA targeting and cure of infected hepatocytes." @default.
- W3164796831 created "2021-06-07" @default.
- W3164796831 creator A5005406597 @default.
- W3164796831 creator A5026085361 @default.
- W3164796831 creator A5040391101 @default.
- W3164796831 creator A5063172143 @default.
- W3164796831 creator A5078457997 @default.
- W3164796831 date "2021-09-01" @default.
- W3164796831 modified "2023-10-08" @default.
- W3164796831 title "Covalently closed circular DNA: The ultimate therapeutic target for curing HBV infections" @default.
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