Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164819280> ?p ?o ?g. }
- W3164819280 endingPage "109194" @default.
- W3164819280 startingPage "109194" @default.
- W3164819280 abstract "Beta-amyloid (Aβ) depresses excitatory synapses by a poorly understood mechanism requiring NMDA receptor (NMDAR) function. Here, we show that increased PSD-95, a major synaptic scaffolding molecule, blocks the effects of Aβ on synapses. The protective effect persists in tissue lacking the AMPA receptor subunit GluA1, which prevents the confounding synaptic potentiation by increased PSD-95. Aβ modifies the conformation of the NMDAR C-terminal domain (CTD) and its interaction with protein phosphatase 1 (PP1), producing synaptic weakening. Higher endogenous levels or overexpression of PSD-95 block Aβ-induced effects on the NMDAR CTD conformation, its interaction with PP1, and synaptic weakening. Our results indicate that increased PSD-95 protects synapses from Aβ toxicity, suggesting that low levels of synaptic PSD-95 may be a molecular sign indicating synapse vulnerability to Aβ. Importantly, pharmacological inhibition of its depalmitoylation increases PSD-95 at synapses and rescues deficits caused by Aβ, possibly opening a therapeutic avenue against Alzheimer's disease." @default.
- W3164819280 created "2021-06-07" @default.
- W3164819280 creator A5007885949 @default.
- W3164819280 creator A5024522246 @default.
- W3164819280 creator A5024576370 @default.
- W3164819280 creator A5028168081 @default.
- W3164819280 creator A5059441599 @default.
- W3164819280 creator A5075532598 @default.
- W3164819280 creator A5089780023 @default.
- W3164819280 date "2021-06-01" @default.
- W3164819280 modified "2023-10-07" @default.
- W3164819280 title "PSD-95 protects synapses from β-amyloid" @default.
- W3164819280 cites W1487695731 @default.
- W3164819280 cites W1653383134 @default.
- W3164819280 cites W1862839122 @default.
- W3164819280 cites W1918304474 @default.
- W3164819280 cites W1952887313 @default.
- W3164819280 cites W1964049915 @default.
- W3164819280 cites W1972384396 @default.
- W3164819280 cites W1973794735 @default.
- W3164819280 cites W1974374321 @default.
- W3164819280 cites W1974467469 @default.
- W3164819280 cites W1977892054 @default.
- W3164819280 cites W1978991736 @default.
- W3164819280 cites W1983553517 @default.
- W3164819280 cites W1984924722 @default.
- W3164819280 cites W1985405412 @default.
- W3164819280 cites W1989211372 @default.
- W3164819280 cites W1992841111 @default.
- W3164819280 cites W1998708235 @default.
- W3164819280 cites W2008679344 @default.
- W3164819280 cites W2008767130 @default.
- W3164819280 cites W2011335492 @default.
- W3164819280 cites W2012012971 @default.
- W3164819280 cites W2014739744 @default.
- W3164819280 cites W2016087140 @default.
- W3164819280 cites W2018458016 @default.
- W3164819280 cites W2029015906 @default.
- W3164819280 cites W2030487055 @default.
- W3164819280 cites W2032089431 @default.
- W3164819280 cites W2035466313 @default.
- W3164819280 cites W2037921808 @default.
- W3164819280 cites W2039132353 @default.
- W3164819280 cites W2048685634 @default.
- W3164819280 cites W2050914944 @default.
- W3164819280 cites W2074426818 @default.
- W3164819280 cites W2079054696 @default.
- W3164819280 cites W2082429191 @default.
- W3164819280 cites W2087824537 @default.
- W3164819280 cites W2092865108 @default.
- W3164819280 cites W2093573816 @default.
- W3164819280 cites W2096410114 @default.
- W3164819280 cites W2117664079 @default.
- W3164819280 cites W2122813148 @default.
- W3164819280 cites W2128401893 @default.
- W3164819280 cites W2131569072 @default.
- W3164819280 cites W2135224381 @default.
- W3164819280 cites W2144907160 @default.
- W3164819280 cites W2146326162 @default.
- W3164819280 cites W2149605366 @default.
- W3164819280 cites W2153438315 @default.
- W3164819280 cites W2155715182 @default.
- W3164819280 cites W2156326104 @default.
- W3164819280 cites W2162400338 @default.
- W3164819280 cites W2171275647 @default.
- W3164819280 cites W2288301981 @default.
- W3164819280 cites W2314634699 @default.
- W3164819280 cites W2426041472 @default.
- W3164819280 cites W2529533701 @default.
- W3164819280 cites W2552573990 @default.
- W3164819280 cites W2567675045 @default.
- W3164819280 cites W2765623109 @default.
- W3164819280 cites W2768580979 @default.
- W3164819280 cites W2770710135 @default.
- W3164819280 cites W3004646285 @default.
- W3164819280 cites W3008258700 @default.
- W3164819280 cites W4245486487 @default.
- W3164819280 cites W903670290 @default.
- W3164819280 doi "https://doi.org/10.1016/j.celrep.2021.109194" @default.
- W3164819280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8237704" @default.
- W3164819280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34077732" @default.
- W3164819280 hasPublicationYear "2021" @default.
- W3164819280 type Work @default.
- W3164819280 sameAs 3164819280 @default.
- W3164819280 citedByCount "43" @default.
- W3164819280 countsByYear W31648192802021 @default.
- W3164819280 countsByYear W31648192802022 @default.
- W3164819280 countsByYear W31648192802023 @default.
- W3164819280 crossrefType "journal-article" @default.
- W3164819280 hasAuthorship W3164819280A5007885949 @default.
- W3164819280 hasAuthorship W3164819280A5024522246 @default.
- W3164819280 hasAuthorship W3164819280A5024576370 @default.
- W3164819280 hasAuthorship W3164819280A5028168081 @default.
- W3164819280 hasAuthorship W3164819280A5059441599 @default.
- W3164819280 hasAuthorship W3164819280A5075532598 @default.
- W3164819280 hasAuthorship W3164819280A5089780023 @default.
- W3164819280 hasBestOaLocation W31648192801 @default.
- W3164819280 hasConcept C112592302 @default.