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- W3164869906 endingPage "5711" @default.
- W3164869906 startingPage "5711" @default.
- W3164869906 abstract "Knee osteoarthritis (OA) is a degenerative knee joint disease that results from the breakdown of joint cartilage and underlying bone, affecting about 3.3% of the world's population. As OA is a multifactorial disease, the underlying pathological process is closely associated with genetic changes in articular cartilage and bone. Many studies have focused on the role of small noncoding RNAs in OA and identified numbers of microRNAs that play important roles in regulating bone and cartilage homeostasis. The connection between other types of small noncoding RNAs, especially tRNA-derived fragments and knee osteoarthritis is still elusive. The observation that there is limited information about small RNAs different than miRNAs in knee OA was very surprising to us, especially given the fact that tRNA fragments are known to participate in a plethora of human diseases and a portion of them are even more abundant than miRNAs. Inspired by these findings, in this review we have summarized the possible involvement of microRNAs and tRNA-derived fragments in the pathology of knee osteoarthritis." @default.
- W3164869906 created "2021-06-07" @default.
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- W3164869906 creator A5052605078 @default.
- W3164869906 creator A5077150430 @default.
- W3164869906 creator A5089287056 @default.
- W3164869906 date "2021-05-27" @default.
- W3164869906 modified "2023-10-06" @default.
- W3164869906 title "Small Noncoding RNAs in Knee Osteoarthritis: The Role of MicroRNAs and tRNA-Derived Fragments" @default.
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