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• W3164881578 abstract "<h3>Background & aims</h3> Metabolic dysfunction–associated fatty liver disease (MAFLD) establishes new criteria for diagnosing fatty liver disease independent of alcohol intake and concomitant viral hepatitis infection. However, the long-term outcomes of patients with MAFLD are sparse. We aimed to describe the characteristics and long-term survival of persons meeting criteria for nonalcoholic fatty liver disease (NAFLD) only (non-MAFLD NAFLD), for both NAFLD and MAFLD (NAFLD-MAFLD), and for MAFLD only (non-NAFLD MAFLD). <h3>Methods</h3> Using data from the Third National Health and Nutrition Examination Survey (NHANES III) 1988–1994, 2997 participants with fatty liver identified via ultrasound were categorized into 3 distinct groups: non-MAFLD NAFLD, NAFLD-MAFLD, and non-NAFLD MAFLD. <h3>Results</h3> Participants in the NAFLD-MAFLD and non-NAFLD MAFLD groups were older, had more metabolic traits and higher mean liver enzymes. Nearly 8% of participants in the non-NAFLD MAFLD group had advanced fibrosis (Fibrosis-4 index >2.67), while only 1.3% and 1.9% in the NAFLD-MAFLD and non-MAFLD NAFLD groups did, respectively (<i>P < .</i>0001). Non-NAFLD MAFLD participants had the highest cumulative incidence of all-cause mortality (26.2%) followed by those with NAFLD-MAFLD then non-MAFLD NAFLD participants (21.1% and 10.6%, respectively; <i>P < .</i>0001). Similar findings were observed for cardiovascular disease–related and other-cause (noncardiovascular disease, noncancer) mortality. Non-NAFLD MAFLD was independently associated with all-cause mortality compared with non-MAFLD NAFLD (adjusted hazard ratio, 2.4; 95% confidence interval, 1.2–4.6; <i>P =</i> .01). <h3>Conclusions</h3> MAFLD criteria identified a significant group of people with more comorbidities and worse prognosis compared with those with NAFLD only. These criteria should be considered in the general population to identify high-risk groups for early interventions." @default.
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• W3164881578 date "2021-10-01" @default.
• W3164881578 modified "2023-10-10" @default.
• W3164881578 title "Differential Clinical Characteristics and Mortality Outcomes in Persons With NAFLD and/or MAFLD" @default.
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• W3164881578 doi "https://doi.org/10.1016/j.cgh.2021.05.029" @default.
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