FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164910760> ?p ?o ?g. }

• W3164910760 endingPage "e0251697" @default.
• W3164910760 startingPage "e0251697" @default.
• W3164910760 abstract "The prevalence of type 2 diabetes mellitus (T2DM) is increasing dramatically worldwide. Dysregulation of microRNA (miRNA) as key regulators of gene expression, has been reported in numerous diseases including diabetes. The aim of this study was to investigate the expression levels of miRNA-122, miRNA-126-3p and miRNA-146a in diabetic and pre-diabetic patients and in healthy individuals, and to determine whether the changes in the level of these miRNAs are reliable biomarkers in diagnosis, prognosis, and pathogenesis of T2DM. Additionally, we examined the relationship between miRNA levels and plasma concentrations of inflammatory factors including tumor necrosis factor alpha (TNF-α) and interleukin 6 (Il-6) as well as insulin resistance. In this case-control study, participants (n = 90) were allocated to three groups (n = 30/group): T2DM, pre-diabetes and healthy individuals as control (males and females, age: 25-65, body mass index: 25-35). Expression of miRNA was determined by real-time polymerase chain reaction (RT-PCR). Furthermore, plasma concentrations of TNF-α, IL-6 and fasting insulin were measured by enzyme-linked immunosorbent assay. Homeostatic model assessment for insulin resistance (HOMA-IR) was calculated as an indicator of insulin resistance. MiRNA-122 levels were higher while miRNA-126-3p and miRNA-146a levels were lower in T2DM and pre-diabetic patients compared to control (p<0.05). Furthermore, a positive correlation was found between miRNA-122 expression and TNF-α (r = 0.82), IL-6 (r = 0.83) and insulin resistance (r = 0.8). Conversely, negative correlations were observed between miRNA-126-3p and miRNA-146a levels and TNF-α (r = -0.7 and r = -0.82 respectively), IL-6 (r = -0.65 and r = -0.78 respectively) as well as insulin resistance (r = -0.67 and r = -0.78 respectively) (all p<0.05). Findings of this study suggest the miRNAs can potentially contribute to the pathogenesis of T2DM. Further studies are required to examine the reproducibility of these findings." @default.
• W3164910760 created "2021-06-07" @default.
• W3164910760 creator A5031098640 @default.
• W3164910760 creator A5038324114 @default.
• W3164910760 creator A5040827457 @default.
• W3164910760 creator A5057524094 @default.
• W3164910760 creator A5066025971 @default.
• W3164910760 creator A5072007938 @default.
• W3164910760 creator A5086321960 @default.
• W3164910760 creator A5087113625 @default.
• W3164910760 date "2021-06-02" @default.
• W3164910760 modified "2023-10-13" @default.
• W3164910760 title "Circulating microRNA-122, microRNA-126-3p and microRNA-146a are associated with inflammation in patients with pre-diabetes and type 2 diabetes mellitus: A case control study" @default.
• W3164910760 cites W1486117034 @default.
• W3164910760 cites W1916975800 @default.
• W3164910760 cites W1949100146 @default.
• W3164910760 cites W1971764287 @default.
• W3164910760 cites W1973214538 @default.
• W3164910760 cites W1981989303 @default.
• W3164910760 cites W1989146491 @default.
• W3164910760 cites W2009277042 @default.
• W3164910760 cites W2016886738 @default.
• W3164910760 cites W2023754969 @default.
• W3164910760 cites W2029135683 @default.
• W3164910760 cites W2030905678 @default.
• W3164910760 cites W2038961236 @default.
• W3164910760 cites W2042125995 @default.
• W3164910760 cites W2049735903 @default.
• W3164910760 cites W2057860524 @default.
• W3164910760 cites W2061998727 @default.
• W3164910760 cites W2064446058 @default.
• W3164910760 cites W2065543285 @default.
• W3164910760 cites W2101508556 @default.
• W3164910760 cites W2104776720 @default.
• W3164910760 cites W2107277218 @default.
• W3164910760 cites W2108244474 @default.
• W3164910760 cites W2111663113 @default.
• W3164910760 cites W2115093090 @default.
• W3164910760 cites W2117833492 @default.
• W3164910760 cites W2122661176 @default.
• W3164910760 cites W2124274499 @default.
• W3164910760 cites W2143166200 @default.
• W3164910760 cites W2160234571 @default.
• W3164910760 cites W2161068194 @default.
• W3164910760 cites W2162674813 @default.
• W3164910760 cites W2172688163 @default.
• W3164910760 cites W2190122418 @default.
• W3164910760 cites W2340948203 @default.
• W3164910760 cites W2345467050 @default.
• W3164910760 cites W2400650343 @default.
• W3164910760 cites W2514378411 @default.
• W3164910760 cites W2526994098 @default.
• W3164910760 cites W2535653919 @default.
• W3164910760 cites W2557910380 @default.
• W3164910760 cites W2586955059 @default.
• W3164910760 cites W2619338750 @default.
• W3164910760 cites W2623081681 @default.
• W3164910760 cites W2745524668 @default.
• W3164910760 cites W2781628037 @default.
• W3164910760 cites W2789860125 @default.
• W3164910760 cites W2794173887 @default.
• W3164910760 cites W2883298821 @default.
• W3164910760 cites W2884194795 @default.
• W3164910760 cites W2911498362 @default.
• W3164910760 cites W2922082686 @default.
• W3164910760 cites W2966470231 @default.
• W3164910760 cites W3015905833 @default.
• W3164910760 cites W4251966062 @default.
• W3164910760 doi "https://doi.org/10.1371/journal.pone.0251697" @default.
• W3164910760 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8171947" @default.
• W3164910760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34077450" @default.
• W3164910760 hasPublicationYear "2021" @default.
• W3164910760 type Work @default.
• W3164910760 sameAs 3164910760 @default.
• W3164910760 citedByCount "35" @default.
• W3164910760 countsByYear W31649107602021 @default.
• W3164910760 countsByYear W31649107602022 @default.
• W3164910760 countsByYear W31649107602023 @default.
• W3164910760 crossrefType "journal-article" @default.
• W3164910760 hasAuthorship W3164910760A5031098640 @default.
• W3164910760 hasAuthorship W3164910760A5038324114 @default.
• W3164910760 hasAuthorship W3164910760A5040827457 @default.
• W3164910760 hasAuthorship W3164910760A5057524094 @default.
• W3164910760 hasAuthorship W3164910760A5066025971 @default.
• W3164910760 hasAuthorship W3164910760A5072007938 @default.
• W3164910760 hasAuthorship W3164910760A5086321960 @default.
• W3164910760 hasAuthorship W3164910760A5087113625 @default.
• W3164910760 hasBestOaLocation W31649107601 @default.
• W3164910760 hasConcept C104317684 @default.
• W3164910760 hasConcept C126322002 @default.
• W3164910760 hasConcept C134018914 @default.
• W3164910760 hasConcept C145059251 @default.
• W3164910760 hasConcept C146304588 @default.
• W3164910760 hasConcept C2776914184 @default.
• W3164910760 hasConcept C2777180221 @default.
• W3164910760 hasConcept C2777391703 @default.
• W3164910760 hasConcept C2779306644 @default.
• W3164910760 hasConcept C2780221984 @default.

• next