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• W3164932007 startingPage "e1009563" @default.
• W3164932007 abstract "Accurate splice site selection is critical for fruitful gene expression. Recently, the mammalian EJC was shown to repress competing, cryptic, splice sites (SS). However, the evolutionary generality of this remains unclear. Here, we demonstrate the Drosophila EJC suppresses hundreds of functional cryptic SS, even though most bear weak splicing motifs and are seemingly incompetent. Mechanistically, the EJC directly conceals cryptic splicing elements by virtue of its position-specific recruitment, preventing aberrant SS definition. Unexpectedly, we discover the EJC inhibits scores of regenerated 5' and 3' recursive SS on segments that have already undergone splicing, and that loss of EJC regulation triggers faulty resplicing of mRNA. An important corollary is that certain intronless cDNA constructs yield unanticipated, truncated transcripts generated by resplicing. We conclude the EJC has conserved roles to defend transcriptome fidelity by (1) repressing illegitimate splice sites on pre-mRNAs, and (2) preventing inadvertent activation of such sites on spliced segments." @default.
• W3164932007 created "2021-06-07" @default.
• W3164932007 creator A5048763567 @default.
• W3164932007 creator A5084592016 @default.
• W3164932007 date "2021-05-25" @default.
• W3164932007 modified "2023-10-13" @default.
• W3164932007 title "The Exon Junction Complex and intron removal prevent re-splicing of mRNA" @default.
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• W3164932007 doi "https://doi.org/10.1371/journal.pgen.1009563" @default.
• W3164932007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8184009" @default.
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• W3164932007 hasPublicationYear "2021" @default.
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