Matches in SemOpenAlex for { <https://semopenalex.org/work/W3164980862> ?p ?o ?g. }
- W3164980862 endingPage "5756" @default.
- W3164980862 startingPage "5756" @default.
- W3164980862 abstract "Polygodial is a “hot” peppery-tasting sesquiterpenoid that was first described for its anti-feedant activity against African armyworms. Using the haploid deletion mutant library of Saccharomyces cerevisiae, a genome-wide mutant screen was performed to shed more light on polygodial’s antifungal mechanism of action. We identified 66 deletion strains that were hypersensitive and 47 that were highly resistant to polygodial treatment. Among the hypersensitive strains, an enrichment was found for genes required for vacuolar acidification, amino acid biosynthesis, nucleosome mobilization, the transcription mediator complex, autophagy and vesicular trafficking, while the resistant strains were enriched for genes encoding cytoskeleton-binding proteins, ribosomal proteins, mitochondrial matrix proteins, components of the heme activator protein (HAP) complex, and known regulators of the target of rapamycin complex 1 (TORC1) signaling. WE confirm that polygodial triggers a dose-dependent vacuolar alkalinization and that it increases Ca2+ influx and inhibits glucose-induced Ca2+ signaling. Moreover, we provide evidence suggesting that TORC1 signaling and its protective agent ubiquitin play a central role in polygodial resistance, suggesting that they can be targeted by polygodial either directly or via altered Ca2+ homeostasis." @default.
- W3164980862 created "2021-06-07" @default.
- W3164980862 creator A5022516804 @default.
- W3164980862 creator A5026407068 @default.
- W3164980862 creator A5044426881 @default.
- W3164980862 creator A5053526663 @default.
- W3164980862 creator A5061788478 @default.
- W3164980862 creator A5061905092 @default.
- W3164980862 creator A5066731798 @default.
- W3164980862 creator A5076457285 @default.
- W3164980862 creator A5084339694 @default.
- W3164980862 creator A5090068893 @default.
- W3164980862 date "2021-05-28" @default.
- W3164980862 modified "2023-09-26" @default.
- W3164980862 title "Investigating the Antifungal Mechanism of Action of Polygodial by Phenotypic Screening in Saccharomyces cerevisiae" @default.
- W3164980862 cites W1497947649 @default.
- W3164980862 cites W15212789 @default.
- W3164980862 cites W1969358694 @default.
- W3164980862 cites W1979319190 @default.
- W3164980862 cites W1984947863 @default.
- W3164980862 cites W1990347645 @default.
- W3164980862 cites W1995872646 @default.
- W3164980862 cites W1999799510 @default.
- W3164980862 cites W2002088854 @default.
- W3164980862 cites W2014237644 @default.
- W3164980862 cites W2020524491 @default.
- W3164980862 cites W2021033588 @default.
- W3164980862 cites W2024760241 @default.
- W3164980862 cites W2026773322 @default.
- W3164980862 cites W2029269187 @default.
- W3164980862 cites W2029616155 @default.
- W3164980862 cites W2031813687 @default.
- W3164980862 cites W2046250502 @default.
- W3164980862 cites W2049505636 @default.
- W3164980862 cites W2054050427 @default.
- W3164980862 cites W2065661282 @default.
- W3164980862 cites W2068049476 @default.
- W3164980862 cites W2069099956 @default.
- W3164980862 cites W2077612148 @default.
- W3164980862 cites W2081226224 @default.
- W3164980862 cites W2083212877 @default.
- W3164980862 cites W2086933719 @default.
- W3164980862 cites W2091963770 @default.
- W3164980862 cites W2093154816 @default.
- W3164980862 cites W2094866226 @default.
- W3164980862 cites W2097816647 @default.
- W3164980862 cites W2099636105 @default.
- W3164980862 cites W2108059588 @default.
- W3164980862 cites W2108543631 @default.
- W3164980862 cites W2109327803 @default.
- W3164980862 cites W2112947833 @default.
- W3164980862 cites W2114371461 @default.
- W3164980862 cites W2125452667 @default.
- W3164980862 cites W2126853108 @default.
- W3164980862 cites W2132694729 @default.
- W3164980862 cites W2136740706 @default.
- W3164980862 cites W2138749370 @default.
- W3164980862 cites W2149792089 @default.
- W3164980862 cites W2151820314 @default.
- W3164980862 cites W2163358830 @default.
- W3164980862 cites W2167468940 @default.
- W3164980862 cites W2172065538 @default.
- W3164980862 cites W2174160083 @default.
- W3164980862 cites W2202647509 @default.
- W3164980862 cites W2274479436 @default.
- W3164980862 cites W2537623931 @default.
- W3164980862 cites W2557155153 @default.
- W3164980862 cites W2576274995 @default.
- W3164980862 cites W2625221760 @default.
- W3164980862 cites W2726091387 @default.
- W3164980862 cites W2783762578 @default.
- W3164980862 cites W2802280177 @default.
- W3164980862 cites W2884233110 @default.
- W3164980862 cites W2913687167 @default.
- W3164980862 cites W2920625439 @default.
- W3164980862 cites W2973410823 @default.
- W3164980862 cites W2982319347 @default.
- W3164980862 cites W3006421071 @default.
- W3164980862 cites W4238180132 @default.
- W3164980862 cites W630303825 @default.
- W3164980862 cites W967980895 @default.
- W3164980862 doi "https://doi.org/10.3390/ijms22115756" @default.
- W3164980862 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8198865" @default.
- W3164980862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34071169" @default.
- W3164980862 hasPublicationYear "2021" @default.
- W3164980862 type Work @default.
- W3164980862 sameAs 3164980862 @default.
- W3164980862 citedByCount "2" @default.
- W3164980862 countsByYear W31649808622022 @default.
- W3164980862 countsByYear W31649808622023 @default.
- W3164980862 crossrefType "journal-article" @default.
- W3164980862 hasAuthorship W3164980862A5022516804 @default.
- W3164980862 hasAuthorship W3164980862A5026407068 @default.
- W3164980862 hasAuthorship W3164980862A5044426881 @default.
- W3164980862 hasAuthorship W3164980862A5053526663 @default.
- W3164980862 hasAuthorship W3164980862A5061788478 @default.
- W3164980862 hasAuthorship W3164980862A5061905092 @default.
- W3164980862 hasAuthorship W3164980862A5066731798 @default.