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• W3165018664 abstract "Although CD8+ T cell tolerance to tissue-specific antigen (TSA) is essential for host homeostasis, the mechanisms underlying peripheral cross-tolerance and whether they may differ between tissue sites remain to be fully elucidated. Here, we demonstrate that peripheral cross-tolerance to intestinal epithelial cell (IEC)-derived antigen involves the generation and suppressive function of FoxP3+CD8+ T cells. FoxP3+CD8+ Treg generation was dependent on intestinal cDC1, whose absence led to a break of tolerance and epithelial destruction. Mechanistically, intestinal cDC1-derived PD-L1, TGFβ, and retinoic acid contributed to the generation of gut-tropic CCR9+CD103+FoxP3+CD8+ Tregs Last, CD103-deficient CD8+ T cells lacked tolerogenic activity in vivo, indicating a role for CD103 in FoxP3+CD8+ Treg function. Our results describe a role for FoxP3+CD8+ Tregs in cross-tolerance in the intestine for which development requires intestinal cDC1." @default.
• W3165018664 created "2021-06-07" @default.
• W3165018664 creator A5000051455 @default.
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• W3165018664 date "2021-06-15" @default.
• W3165018664 modified "2023-10-14" @default.
• W3165018664 title "Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3 ⁺ CD8 ⁺ T _regs" @default.
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• W3165018664 doi "https://doi.org/10.1126/sciimmunol.abd3774" @default.
• W3165018664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34088744" @default.

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