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• W3165034639 abstract "Chronic inflammation is the initial stage of liver fibrosis-related hepatocellular carcinoma (HCC) development. Also, HCC is a global disease resulting from several etiological factors. HCC incidence can be triggered by alcohol abuse, non-alcoholic steatohepatitis (NASH), viral hepatitis B (HBV), viral hepatitis C (HCV), and non-alcoholic fatty liver disease (NAFLD). Liver chronic inflammation significantly correlates to TNF-α (Tumor Necrosis Factor-α) and IL-6 (interleukin 6) expression. This laboratory work aimed to investigate the effect of green material Moringa oleifera leaf powder (MOLP) on the expression of both pro-inflammatory cytokines. A semi-quantitative approach quantified the expression of TNF-α and IL-6. This research was conducted using an animal model induced by intraperitoneal injection of CCl4 solution. The results showed that green material Moringa oleifera could reduce IL-6 and TNF-α expression. Importantly, MOLP exposure can decrease the pro-inflammatory cell population in the liver parenchymal area. Hence, the application of green material Moringa oleifera might be potential as the local bioresources agent against liver inflammation-linked fibrosis. The exploration of MOLP in the future drug discovery model may significantly contribute to the prevention of hepatocellular carcinoma." @default.
• W3165034639 created "2021-06-07" @default.
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• W3165034639 date "2021-01-01" @default.
• W3165034639 modified "2023-09-29" @default.
• W3165034639 title "Anti-inflammatory properties green material Moringa oleifera leaf powder (MOLP) on the progression of hepatocellular carcinoma-associated liver fibrosis" @default.
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• W3165034639 doi "https://doi.org/10.1063/5.0052574" @default.
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