Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165038566> ?p ?o ?g. }
- W3165038566 abstract "The construction and maturation of the postsynaptic apparatus are crucial for synapse and dendrite development. The fundamental mechanisms underlying these processes are most often studied in glutamatergic central synapses in vertebrates. Whether the same principles apply to excitatory cholinergic synapses, such as those found in the insect central nervous system, is not known. To address this question, we investigated a group of projection neurons in the Drosophila larval visual system, the ventral lateral neurons (LNvs), and identified nAchRα1 (Dα1) and nAchRα6 (Dα6) as the main functional nicotinic acetylcholine receptor (nAchR) subunits in the larval LNvs. Using morphological analyses and calcium imaging studies, we demonstrated critical roles of these two subunits in supporting dendrite morphogenesis and synaptic transmission. Furthermore, our RNA sequencing analyses and endogenous tagging approach identified distinct transcriptional controls over the two subunits in the LNvs, which led to the up-regulation of Dα1 and down-regulation of Dα6 during larval development as well as to an activity-dependent suppression of Dα1 Additional functional analyses of synapse formation and dendrite dynamics further revealed a close association between the temporal regulation of individual nAchR subunits and their sequential requirements during the cholinergic synapse maturation. Together, our findings support transcriptional control of nAchR subunits as a core element of developmental and activity-dependent regulation of central cholinergic synapses." @default.
- W3165038566 created "2021-06-07" @default.
- W3165038566 creator A5000357671 @default.
- W3165038566 creator A5011144900 @default.
- W3165038566 creator A5012888044 @default.
- W3165038566 creator A5016561977 @default.
- W3165038566 creator A5051862060 @default.
- W3165038566 creator A5064302953 @default.
- W3165038566 creator A5072273716 @default.
- W3165038566 creator A5076324699 @default.
- W3165038566 creator A5076501435 @default.
- W3165038566 date "2021-05-31" @default.
- W3165038566 modified "2023-10-17" @default.
- W3165038566 title "Temporal regulation of nicotinic acetylcholine receptor subunits supports central cholinergic synapse development in <i>Drosophila</i>" @default.
- W3165038566 cites W1598713761 @default.
- W3165038566 cites W1900806927 @default.
- W3165038566 cites W1964737820 @default.
- W3165038566 cites W1973431365 @default.
- W3165038566 cites W1980294445 @default.
- W3165038566 cites W1985194591 @default.
- W3165038566 cites W1986156509 @default.
- W3165038566 cites W1993002058 @default.
- W3165038566 cites W1996303706 @default.
- W3165038566 cites W1997210578 @default.
- W3165038566 cites W1997543121 @default.
- W3165038566 cites W2000513961 @default.
- W3165038566 cites W2002515881 @default.
- W3165038566 cites W2003203798 @default.
- W3165038566 cites W2006969689 @default.
- W3165038566 cites W2010022125 @default.
- W3165038566 cites W2012418668 @default.
- W3165038566 cites W2015173843 @default.
- W3165038566 cites W2017286200 @default.
- W3165038566 cites W2019510839 @default.
- W3165038566 cites W2022957145 @default.
- W3165038566 cites W2028054134 @default.
- W3165038566 cites W2029710875 @default.
- W3165038566 cites W2031130044 @default.
- W3165038566 cites W2031678757 @default.
- W3165038566 cites W2034124800 @default.
- W3165038566 cites W2035946761 @default.
- W3165038566 cites W2054159696 @default.
- W3165038566 cites W2054234789 @default.
- W3165038566 cites W2058427270 @default.
- W3165038566 cites W2059234084 @default.
- W3165038566 cites W2073724409 @default.
- W3165038566 cites W2076995634 @default.
- W3165038566 cites W2082210532 @default.
- W3165038566 cites W2085170707 @default.
- W3165038566 cites W2103969182 @default.
- W3165038566 cites W2104838343 @default.
- W3165038566 cites W2105536667 @default.
- W3165038566 cites W2108267537 @default.
- W3165038566 cites W2115699934 @default.
- W3165038566 cites W2116120324 @default.
- W3165038566 cites W2117770051 @default.
- W3165038566 cites W2122132730 @default.
- W3165038566 cites W2134505400 @default.
- W3165038566 cites W2134802701 @default.
- W3165038566 cites W2134896896 @default.
- W3165038566 cites W2134927362 @default.
- W3165038566 cites W2135286498 @default.
- W3165038566 cites W2154626303 @default.
- W3165038566 cites W2167180065 @default.
- W3165038566 cites W2174802300 @default.
- W3165038566 cites W2234083220 @default.
- W3165038566 cites W2258786360 @default.
- W3165038566 cites W2290925166 @default.
- W3165038566 cites W2427261560 @default.
- W3165038566 cites W2523262515 @default.
- W3165038566 cites W2538939159 @default.
- W3165038566 cites W2552399730 @default.
- W3165038566 cites W2621121450 @default.
- W3165038566 cites W2767075862 @default.
- W3165038566 cites W2790947724 @default.
- W3165038566 cites W2885764841 @default.
- W3165038566 cites W2899359772 @default.
- W3165038566 cites W2949501662 @default.
- W3165038566 cites W2971660213 @default.
- W3165038566 cites W2990575494 @default.
- W3165038566 cites W3084263356 @default.
- W3165038566 cites W3096195703 @default.
- W3165038566 doi "https://doi.org/10.1073/pnas.2004685118" @default.
- W3165038566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8202021" @default.
- W3165038566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34074746" @default.
- W3165038566 hasPublicationYear "2021" @default.
- W3165038566 type Work @default.
- W3165038566 sameAs 3165038566 @default.
- W3165038566 citedByCount "5" @default.
- W3165038566 countsByYear W31650385662021 @default.
- W3165038566 countsByYear W31650385662022 @default.
- W3165038566 countsByYear W31650385662023 @default.
- W3165038566 crossrefType "journal-article" @default.
- W3165038566 hasAuthorship W3165038566A5000357671 @default.
- W3165038566 hasAuthorship W3165038566A5011144900 @default.
- W3165038566 hasAuthorship W3165038566A5012888044 @default.
- W3165038566 hasAuthorship W3165038566A5016561977 @default.
- W3165038566 hasAuthorship W3165038566A5051862060 @default.
- W3165038566 hasAuthorship W3165038566A5064302953 @default.
- W3165038566 hasAuthorship W3165038566A5072273716 @default.