FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165048939> ?p ?o ?g. }

• W3165048939 endingPage "1219" @default.
• W3165048939 startingPage "1210" @default.
• W3165048939 abstract "Cholesterol-25-hydroxylase (CH25H) is a membrane protein associated with endoplasmic reticulum, and it is an interferon-stimulated factor regulated by interferon. CH25H catalyzes cholesterol to produce 25-hydroxycholesterol (25HC) by adding a second hydroxyl to the 25th carbon atom of cholesterol. Recent studies have shown that both CH25H and 25HC could inhibit the replication of many viruses. In this study, we found that ectopic expression of CH25H in HEK-293T and BHK-21 cell lines could inhibit the replication of Seneca Valley virus (SVV) and that there was no species difference. On the other hand, the knockdown of CH25H could enhance the replication of SVV in HEK-293T and BHK-21 cells, indicating the importance of CH25H. To some extent, the CH25H mutant without hydroxylase activity also lost its ability to inhibit SVV amplification. Further studies demonstrated that 25HC was involved in the entire life cycle of SVV, especially in repressing its adsorption process. This study reveals that CH25H exerts the advantage of innate immunity mainly by producing 25HC to block virion adsorption." @default.
• W3165048939 created "2021-06-07" @default.
• W3165048939 creator A5025891723 @default.
• W3165048939 creator A5045767657 @default.
• W3165048939 creator A5061014207 @default.
• W3165048939 creator A5065859286 @default.
• W3165048939 creator A5066231460 @default.
• W3165048939 creator A5074707535 @default.
• W3165048939 creator A5089879921 @default.
• W3165048939 date "2021-06-01" @default.
• W3165048939 modified "2023-10-16" @default.
• W3165048939 title "Cholesterol-25-Hydroxylase Suppresses Seneca Valley Virus Infection via Producing 25-Hydroxycholesterol to Block Adsorption Procedure" @default.
• W3165048939 cites W1932917655 @default.
• W3165048939 cites W1964899822 @default.
• W3165048939 cites W1970133028 @default.
• W3165048939 cites W1984391988 @default.
• W3165048939 cites W1994879221 @default.
• W3165048939 cites W1998477311 @default.
• W3165048939 cites W2012397588 @default.
• W3165048939 cites W2017476273 @default.
• W3165048939 cites W2020363742 @default.
• W3165048939 cites W2021877458 @default.
• W3165048939 cites W2042429611 @default.
• W3165048939 cites W2046686885 @default.
• W3165048939 cites W2066780104 @default.
• W3165048939 cites W2072517432 @default.
• W3165048939 cites W2078406520 @default.
• W3165048939 cites W2084656052 @default.
• W3165048939 cites W2088436733 @default.
• W3165048939 cites W2110880203 @default.
• W3165048939 cites W2126711569 @default.
• W3165048939 cites W2130879777 @default.
• W3165048939 cites W2146058076 @default.
• W3165048939 cites W2161834691 @default.
• W3165048939 cites W2164969921 @default.
• W3165048939 cites W2167200907 @default.
• W3165048939 cites W2236297534 @default.
• W3165048939 cites W2505039247 @default.
• W3165048939 cites W2534814186 @default.
• W3165048939 cites W2566579202 @default.
• W3165048939 cites W2598033793 @default.
• W3165048939 cites W2619331044 @default.
• W3165048939 cites W2783265629 @default.
• W3165048939 cites W2901250898 @default.
• W3165048939 cites W2979884142 @default.
• W3165048939 doi "https://doi.org/10.1007/s12250-021-00377-9" @default.
• W3165048939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34061318" @default.
• W3165048939 hasPublicationYear "2021" @default.
• W3165048939 type Work @default.
• W3165048939 sameAs 3165048939 @default.
• W3165048939 citedByCount "2" @default.
• W3165048939 countsByYear W31650489392022 @default.
• W3165048939 crossrefType "journal-article" @default.
• W3165048939 hasAuthorship W3165048939A5025891723 @default.
• W3165048939 hasAuthorship W3165048939A5045767657 @default.
• W3165048939 hasAuthorship W3165048939A5061014207 @default.
• W3165048939 hasAuthorship W3165048939A5065859286 @default.
• W3165048939 hasAuthorship W3165048939A5066231460 @default.
• W3165048939 hasAuthorship W3165048939A5074707535 @default.
• W3165048939 hasAuthorship W3165048939A5089879921 @default.
• W3165048939 hasBestOaLocation W31650489391 @default.
• W3165048939 hasConcept C104317684 @default.
• W3165048939 hasConcept C140704245 @default.
• W3165048939 hasConcept C143065580 @default.
• W3165048939 hasConcept C158617107 @default.
• W3165048939 hasConcept C159047783 @default.
• W3165048939 hasConcept C173396325 @default.
• W3165048939 hasConcept C174510640 @default.
• W3165048939 hasConcept C185592680 @default.
• W3165048939 hasConcept C2522874641 @default.
• W3165048939 hasConcept C55493867 @default.
• W3165048939 hasConcept C86803240 @default.
• W3165048939 hasConcept C95444343 @default.
• W3165048939 hasConcept C97037327 @default.
• W3165048939 hasConceptScore W3165048939C104317684 @default.
• W3165048939 hasConceptScore W3165048939C140704245 @default.
• W3165048939 hasConceptScore W3165048939C143065580 @default.
• W3165048939 hasConceptScore W3165048939C158617107 @default.
• W3165048939 hasConceptScore W3165048939C159047783 @default.
• W3165048939 hasConceptScore W3165048939C173396325 @default.
• W3165048939 hasConceptScore W3165048939C174510640 @default.
• W3165048939 hasConceptScore W3165048939C185592680 @default.
• W3165048939 hasConceptScore W3165048939C2522874641 @default.
• W3165048939 hasConceptScore W3165048939C55493867 @default.
• W3165048939 hasConceptScore W3165048939C86803240 @default.
• W3165048939 hasConceptScore W3165048939C95444343 @default.
• W3165048939 hasConceptScore W3165048939C97037327 @default.
• W3165048939 hasIssue "5" @default.
• W3165048939 hasLocation W31650489391 @default.
• W3165048939 hasLocation W31650489392 @default.
• W3165048939 hasLocation W31650489393 @default.
• W3165048939 hasOpenAccess W3165048939 @default.
• W3165048939 hasPrimaryLocation W31650489391 @default.
• W3165048939 hasRelatedWork W1554885052 @default.
• W3165048939 hasRelatedWork W1970360080 @default.
• W3165048939 hasRelatedWork W2033712814 @default.
• W3165048939 hasRelatedWork W2043676834 @default.
• W3165048939 hasRelatedWork W2051913433 @default.

• next