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- W3165133043 abstract "Abstract Background Subjective cognitive decline, perceived worsening of cognitive ability without apparent performance issues on clinical assessment, may be an important precursor to dementia. While previous cross-sectional research has demonstrated aberrant brain functional connectivity in subjective cognitive decline, longitudinal evaluation remains limited. Methods Here, we examined trajectories of functional connectivity over three measurement occasions ~18 months apart, using voxelwise latent growth models in cognitively unimpaired older adults with varying self-report of subjective cognitive decline (N = 69). Results We found that individuals who reported a greater degree of subjective cognitive decline showed a larger subsequent decrease in connectivity between components of the default mode network and increase in connectivity between salience and default mode network components. The change in functional connectivity was observed in the absence of change in cognitive performance. Conclusion The results indicate that functional brain changes may underly the experience of cognitive decline before deterioration reaches a level detected by formal cognitive assessment." @default.
- W3165133043 created "2021-06-07" @default.
- W3165133043 creator A5036025510 @default.
- W3165133043 creator A5086906399 @default.
- W3165133043 date "2021-05-31" @default.
- W3165133043 modified "2023-09-27" @default.
- W3165133043 title "Longitudinal change in hippocampal and dorsal anterior insulae functional connectivity in subjective cognitive decline" @default.
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- W3165133043 doi "https://doi.org/10.1186/s13195-021-00847-y" @default.
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