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- W3165136985 abstract "More than a century ago, Victor Eisenmenger published the case of a “powerfully-built” man in his thirties with longstanding cyanosis and effort-induced breathlessness, who eventually developed heart failure, oedema and died suddenly following “violent” haemoptysis. The patient, who was found to have a large ventricular septal defect (VSD) on autopsy, represented the first case in the scientific literature of what would posthumously be called Eisenmenger complex. Sixty years later, Paul Wood described the core pathophysiological features of Eisenmenger syndrome (ES): severe pulmonary vascular disease with systemic levels of pulmonary vascular resistance and shunt reversal across a congenital heart defect causing chronic cyanosis. Despite major advances in the management of ES over recent decades, including the use of pulmonary arterial hypertension (PAH) therapies to improve functional capacity and prognosis [ 1 Galiè N. Beghetti M. Gatzoulis M.A. et al. Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study. Circulation. 2006; 114: 48-54 Crossref PubMed Scopus (673) Google Scholar , 2 Dimopoulos K. Inuzuka R. Goletto S. et al. Improved survival among patients with Eisenmenger syndrome receiving advanced therapy for pulmonary arterial hypertension. Circulation. 2010; 121: 20-25 Crossref PubMed Scopus (264) Google Scholar , 3 Diller G.-P. Alonso-Gonzalez R. Dimopoulos K. et al. Disease targeting therapies in patients with Eisenmenger syndrome: response to treatment and long-term efficiency. Int. J. Cardiol. 2013; 167: 840-847 Abstract Full Text Full Text PDF PubMed Scopus (45) Google Scholar ], there are still many unknowns in terms of the pathophysiology of ES and the pathogenesis of its numerous potential complications." @default.
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- W3165136985 date "2021-08-01" @default.
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- W3165136985 title "Systemic microangiopathy in Eisenmenger syndrome – The missing link?" @default.
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- W3165136985 doi "https://doi.org/10.1016/j.ijcard.2021.05.032" @default.
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