FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165162313> ?p ?o ?g. }

• W3165162313 endingPage "1808" @default.
• W3165162313 startingPage "1795" @default.
• W3165162313 abstract "RO7062931 is an N-acetylgalactosamine (GalNAc)-conjugated single-stranded locked nucleic acid oligonucleotide complementary to HBV RNA. GalNAc conjugation targets the liver through the asialoglycoprotein receptor (ASGPR). This two-part phase 1 study evaluated the safety, pharmacokinetics, and pharmacodynamics of RO7062931 in healthy volunteers and patients with chronic hepatitis B (CHB) who were virologically suppressed.Part 1 was a single ascending dose study in healthy volunteers randomized to receive a single RO7062931 dose (0.1-4.0 mg/kg), or placebo. Part 2 was a multiple ascending dose study in patients with CHB randomized to receive RO7062931 at 0.5, 1.5, or 3.0 mg/kg or placebo every month for a total of 2 doses (Part 2a) or RO7062931 at 3.0 mg/kg every 2 weeks, 3.0 mg/kg every week (QW), or 4.0 mg/kg QW or placebo for a total of 3-5 doses (Part 2b). Sixty healthy volunteers and 59 patients received RO7062931 or placebo. The majority of adverse events (AEs) reported were mild in intensity. Common AEs included self-limiting injection site reactions and influenza-like illness. Supradose-proportional increases in RO7062931 plasma exposure and urinary excretion occurred at doses ≥3.0 mg/kg. In patients with CHB, RO7062931 resulted in dose-dependent and time-dependent reduction in HBsAg versus placebo. The greatest HBsAg declines from baseline were achieved with the 3.0 mg/kg QW dose regimen (mean nadir ~0.5 log10 IU/mL) independent of HBeAg status.RO7062931 is safe and well tolerated at doses up to 4.0 mg/kg QW. Supradose-proportional exposure at doses of 3.0-4.0 mg/kg was indicative of partial saturation of the ASGPR-mediated liver uptake system. Dose-dependent declines in HBsAg demonstrated target engagement with RO7062931." @default.
• W3165162313 created "2021-06-07" @default.
• W3165162313 creator A5004194007 @default.
• W3165162313 creator A5009057362 @default.
• W3165162313 creator A5014701689 @default.
• W3165162313 creator A5017650720 @default.
• W3165162313 creator A5019355286 @default.
• W3165162313 creator A5019669804 @default.
• W3165162313 creator A5020720433 @default.
• W3165162313 creator A5022732012 @default.
• W3165162313 creator A5030066654 @default.
• W3165162313 creator A5033686667 @default.
• W3165162313 creator A5040147082 @default.
• W3165162313 creator A5044606541 @default.
• W3165162313 creator A5059964858 @default.
• W3165162313 creator A5060404344 @default.
• W3165162313 creator A5062263962 @default.
• W3165162313 creator A5066097652 @default.
• W3165162313 creator A5071099098 @default.
• W3165162313 creator A5073784411 @default.
• W3165162313 creator A5074915165 @default.
• W3165162313 creator A5088608185 @default.
• W3165162313 creator A5088842832 @default.
• W3165162313 creator A5088890103 @default.
• W3165162313 creator A5089108312 @default.
• W3165162313 creator A5090007352 @default.
• W3165162313 date "2021-08-25" @default.
• W3165162313 modified "2023-10-16" @default.
• W3165162313 title "Clinical Study of Single‐Stranded Oligonucleotide RO7062931 in Healthy Volunteers and Patients With Chronic Hepatitis B" @default.
• W3165162313 cites W2006774237 @default.
• W3165162313 cites W2007113606 @default.
• W3165162313 cites W2032152239 @default.
• W3165162313 cites W2044204671 @default.
• W3165162313 cites W2119387393 @default.
• W3165162313 cites W2183502108 @default.
• W3165162313 cites W2194172371 @default.
• W3165162313 cites W2481374159 @default.
• W3165162313 cites W2531015819 @default.
• W3165162313 cites W2562815279 @default.
• W3165162313 cites W2563642244 @default.
• W3165162313 cites W2605785536 @default.
• W3165162313 cites W2633859106 @default.
• W3165162313 cites W2739640246 @default.
• W3165162313 cites W2753361796 @default.
• W3165162313 cites W2757654367 @default.
• W3165162313 cites W2765408218 @default.
• W3165162313 cites W2791790530 @default.
• W3165162313 cites W2795531081 @default.
• W3165162313 cites W2900235043 @default.
• W3165162313 cites W2900781853 @default.
• W3165162313 cites W2902038362 @default.
• W3165162313 cites W2944193734 @default.
• W3165162313 cites W2946997025 @default.
• W3165162313 cites W2981927057 @default.
• W3165162313 cites W3013108313 @default.
• W3165162313 cites W3025321958 @default.
• W3165162313 cites W3031206422 @default.
• W3165162313 cites W3036363721 @default.
• W3165162313 cites W3084357673 @default.
• W3165162313 cites W3193978878 @default.
• W3165162313 cites W4245934588 @default.
• W3165162313 doi "https://doi.org/10.1002/hep.31920" @default.
• W3165162313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34037271" @default.
• W3165162313 hasPublicationYear "2021" @default.
• W3165162313 type Work @default.
• W3165162313 sameAs 3165162313 @default.
• W3165162313 citedByCount "18" @default.
• W3165162313 countsByYear W31651623132021 @default.
• W3165162313 countsByYear W31651623132022 @default.
• W3165162313 countsByYear W31651623132023 @default.
• W3165162313 crossrefType "journal-article" @default.
• W3165162313 hasAuthorship W3165162313A5004194007 @default.
• W3165162313 hasAuthorship W3165162313A5009057362 @default.
• W3165162313 hasAuthorship W3165162313A5014701689 @default.
• W3165162313 hasAuthorship W3165162313A5017650720 @default.
• W3165162313 hasAuthorship W3165162313A5019355286 @default.
• W3165162313 hasAuthorship W3165162313A5019669804 @default.
• W3165162313 hasAuthorship W3165162313A5020720433 @default.
• W3165162313 hasAuthorship W3165162313A5022732012 @default.
• W3165162313 hasAuthorship W3165162313A5030066654 @default.
• W3165162313 hasAuthorship W3165162313A5033686667 @default.
• W3165162313 hasAuthorship W3165162313A5040147082 @default.
• W3165162313 hasAuthorship W3165162313A5044606541 @default.
• W3165162313 hasAuthorship W3165162313A5059964858 @default.
• W3165162313 hasAuthorship W3165162313A5060404344 @default.
• W3165162313 hasAuthorship W3165162313A5062263962 @default.
• W3165162313 hasAuthorship W3165162313A5066097652 @default.
• W3165162313 hasAuthorship W3165162313A5071099098 @default.
• W3165162313 hasAuthorship W3165162313A5073784411 @default.
• W3165162313 hasAuthorship W3165162313A5074915165 @default.
• W3165162313 hasAuthorship W3165162313A5088608185 @default.
• W3165162313 hasAuthorship W3165162313A5088842832 @default.
• W3165162313 hasAuthorship W3165162313A5088890103 @default.
• W3165162313 hasAuthorship W3165162313A5089108312 @default.
• W3165162313 hasAuthorship W3165162313A5090007352 @default.
• W3165162313 hasBestOaLocation W31651623131 @default.
• W3165162313 hasConcept C111113717 @default.
• W3165162313 hasConcept C112705442 @default.

• next