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• W3165167135 endingPage "155590" @default.
• W3165167135 startingPage "155590" @default.
• W3165167135 abstract "Multiple sclerosis (MS) is the most common non-traumatic neurological cause of disability in young adults. Physical activity, particularly exercise training, is an evidence-based approach to managing symptoms, restoring function, and improving overall wellness in people with MS. As well, the use of probiotics can be effective in reducing the damage from inflammation in MS patients.The study aimed to address changes in leptin, serotonin, and cortisol following eight weeks of aerobic exercise along with probiotic intake in a cuprizone-induced demyelination mouse model of MS.Mice were exposed to cuprizone for 12 weeks. After 5 weeks, beam and performance tests were performed on them. The mice (n = 5 per group) were randomly divided into five groups: control (C), MS, MS with exercise (MS + Exe), MS with probiotic (MS + Prob), and MS with probiotic and exercise (MS + Prob + Exe). Exercise groups performed aerobic exercises 5 days a week, 10 min in the first week, 20 min in the second week, and 30 min daily in the third week until the eighth week. In the probiotic groups, the mice received probiotic by gavage. They were sacrificed after 3 months. Biochemical and molecular biology analyses were performed.The results showed that leptin gene expression values in the MS + Prob + Exe, MS + Prob, and MS + Exe groups showed a decrease compared to the MS group, but the reduction was not significant (p > 0.05). Also, the leptin Elisa test in these intervention groups showed a significant decrease (P < 0.05). The serotonin gene expression values in the MS + Prob + Exe, MS + Prob, and MS + Exe groups were increased compared to the MS group, but the increase was not significant (p > 0.05). Furthermore, the serotonin Elisa test in these intervention groups showed a significant increase (P < 0.05). The cortisol Elisa test values in the MS + Exe and MS + Prob groups exhibited a decrease compared to the MS group, but the reduction was not significant (p > 0.05).Overall, these results suggest that lifestyle interventions can be effective in improving pathological factors in patients with MS." @default.
• W3165167135 created "2021-06-07" @default.
• W3165167135 creator A5026764568 @default.
• W3165167135 creator A5030298670 @default.
• W3165167135 creator A5061660560 @default.
• W3165167135 date "2021-08-01" @default.
• W3165167135 modified "2023-10-16" @default.
• W3165167135 title "Changes in leptin, serotonin, and cortisol after eight weeks of aerobic exercise with probiotic intake in a cuprizone-induced demyelination mouse model of multiple sclerosis" @default.
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• W3165167135 doi "https://doi.org/10.1016/j.cyto.2021.155590" @default.
• W3165167135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34049259" @default.
• W3165167135 hasPublicationYear "2021" @default.
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