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• W3165169216 abstract "Abstract Lymphopenia is common in severe COVID-19 disease, yet the mechanisms are poorly understood. In 148 patients with severe COVID-19, we found lymphopenia was associated with worse survival. CD4 + lymphopenia predominated, with lower CD4 + /CD8 + ratios in severe COVID-19 compared to recovered, mild disease (p<0.0001). In severe disease, immunodominant CD4 + T cell responses to Spike-1(S1) produced increased in vitro TNF-α, but impaired proliferation and increased susceptibility to activation-induced cell death (AICD). CD4 + TNF-α + T cell responses inversely correlated with absolute CD4 + counts from severe COVID-19 patients (n=76; R=-0.744, P<0.0001). TNF-α blockade including infliximab or anti-TNFRI antibodies strikingly rescued S1-specific CD4 + proliferation and abrogated S1-AICD in severe COVID-19 patients (P<0.001). Single-cell RNAseq demonstrated downregulation of Type-1 cytokines and NFκB signaling in S1-stimulated CD4 + cells with infliximab treatment. Lung CD4 + T cells in severe COVID-19 were reduced and produced higher TNF-α versus PBMC. Together, our findings show COVID-19-associated CD4 + lymphopenia and dysfunction is autocrine TNF-α/TNFRI-dependent and therapies targeting TNF-α may be beneficial in severe COVID-19. One Sentence Summary Autocrine TNF-α/TNFRI regulates CD4 + T cell lymphopenia and dysfunction in severe COVID-19 disease." @default.
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• W3165169216 date "2021-06-03" @default.
• W3165169216 modified "2023-09-25" @default.
• W3165169216 title "CD4⁺ T cell lymphopenia and dysfunction in severe COVID-19 disease is autocrine TNF-α/TNFRI-dependent" @default.
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• W3165169216 doi "https://doi.org/10.1101/2021.06.02.446831" @default.
• W3165169216 hasPublicationYear "2021" @default.
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