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• W3165182740 abstract "Abstract Background: This study aims to evaluate the therapeutic effect of intra-articular injection of different doses of exosomes derived from mesenchymal stem cells(MSC) and the effect on nerve and cartilage repair in a monoiodoacetate (MIA) model of knee osteoarthritis(OA) in rats. Methods: The pain rat model was established by injection of sodium monoiodate (MIA) into the knee joint of the rats, the knee joint and dorsal root ganglion (DRG) of rats were collected for histologic analyses. For pain assessment, On 1 day before MIA injection, 7, 14 days after MIA injection and 7, 14,28 days after Exosome injection,paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) was measured. Articular cartilage were assessed on HE by ORASI grade and the expression of ATF-3 and GAP-43 in dorsal root ganglion (DRG) using immunohistochemistry and western blotting in MIA-induced rats. Results: In our study, exosome significantly improved PWT and PWL value with a dose-dependent manner on 7, 14, and 28 days after intra-articular Exosome compared with the MIA group. Exosome injection therapy also has a repairing effect on cartilage on 28 days after intra-articular Exosome compared with the MIA group. Moreover, exosome treatment significantly upregulated GAP-43 protein and downregulated ATF-3 protein in the DRG with a dose-dependent manner of the OA rat. Conclusion: Intraarticular injection of different doses of mesenchymal stem cell derived exosomes in MIA-induced rats osteoarthritis, the analgesic effect of exosome was dose-dependent. Moreover, the repair of nerve by exosomes is earlier than that of cartilage." @default.
• W3165182740 created "2021-06-07" @default.
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• W3165182740 date "2021-05-24" @default.
• W3165182740 modified "2023-09-24" @default.
• W3165182740 title "Intraarticular Injection of Different Doses of Mesenchymal Stem Cell Derived Exosomes Reduces ATF-3 Expression in the Dorsal Root Ganglion in Monoiodoacetate-Induced Rats of Osteoarthritis" @default.
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• W3165182740 doi "https://doi.org/10.21203/rs.3.rs-535017/v1" @default.
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