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• W3165186859 abstract "Depletion of nicotinamide adenine dinucleotide (NAD+ ), a central redox cofactor and the substrate of key metabolic enzymes, is the causative factor of a number of inherited and acquired diseases in humans. Primary deficiencies of NAD+ homeostasis are the result of impaired biosynthesis, while secondary deficiencies can arise due to other factors affecting NAD+ homeostasis, such as increased NAD+ consumption or dietary deficiency of its vitamin B3 precursors. NAD+ depletion can manifest in a wide variety of pathological phenotypes, ranging from rare inherited defects, characterized by congenital malformations, retinal degeneration, and/or encephalopathy, to more common multifactorial, often age-related, diseases. Here, we discuss NAD+ biochemistry and metabolism and provide an overview of the etiology and pathological consequences of alterations of the NAD+ metabolism in humans. Finally, we discuss the state of the art of the potential therapeutic implications of NAD+ repletion for boosting health as well as treating rare and common diseases, and the possibilities to achieve this by means of the different NAD+ -enhancing agents." @default.
• W3165186859 created "2021-06-07" @default.
• W3165186859 creator A5014139372 @default.
• W3165186859 creator A5016480998 @default.
• W3165186859 creator A5040743356 @default.
• W3165186859 creator A5049502258 @default.
• W3165186859 date "2021-05-27" @default.
• W3165186859 modified "2023-10-08" @default.
• W3165186859 title "NAD ⁺ homeostasis in human health and disease" @default.
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