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- W3165206801 abstract "Summary Approaches to control basal ganglia neural activity in real-time are needed to clarify the causal role of 8-35 Hz (“beta band”) oscillatory dynamics in the manifestation of Parkinson’s disease (PD) motor signs. Here, we show that resonant beta oscillations evoked by electrical pulse with precise amplitude and timing can be used to predictably suppress or amplify spontaneous beta band activity in the internal segment of the globus pallidus (GPi) in the human. Using this approach, referred to as closed-loop evoked interference deep brain stimulation (eiDBS), we could suppress or amplify frequencyspecific (16-22 Hz) neural activity in a PD patient. Our results highlight the utility of eiDBS to characterize the role of oscillatory dynamics in PD and other brain conditions, and to develop personalized neuromodulation systems." @default.
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- W3165206801 date "2021-05-23" @default.
- W3165206801 modified "2023-09-23" @default.
- W3165206801 title "Controlling pallidal oscillations in real-time in Parkinson’s disease using evoked interference deep brain stimulation (eiDBS): proof of concept in the human" @default.
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- W3165206801 doi "https://doi.org/10.1101/2021.05.22.445251" @default.
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