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- W3165207816 abstract "Great progress has been made in understanding the genetic and molecular basis of pheochromocytoma and paragangliomas (PPGLs). This review highlights the new standards in the diagnosis and management of pediatric PPGLs.The vast majority of pediatric PPGLs have an associated germline mutation, making genetic studies imperative in the work up of these tumors. Somatostatin receptor-based imaging modalities such as 68Ga-DOTATATE and 64Cu-DOTATATE are shown to have the greatest sensitivity in pediatric PPGLs. Peptide receptor radionuclide therapies (PRRTs) such as 177Lu-DOTATATE are shown to have efficacy for treating PPGLs.Genetics play an important role in pediatric PPGLs. Advances in somatostatin receptor-based technology have led to use of 68Ga-DOTATATE and 64Cu-DOTATATE as preferred imaging modalities. While surgery remains the mainstay for management of PPGLs, PRRT is emerging as a treatment option for PPGLs." @default.
- W3165207816 created "2021-06-07" @default.
- W3165207816 creator A5032111369 @default.
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- W3165207816 date "2021-05-25" @default.
- W3165207816 modified "2023-10-13" @default.
- W3165207816 title "Pheochromocytomas and paragangliomas" @default.
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- W3165207816 doi "https://doi.org/10.1097/mop.0000000000001029" @default.
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