FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165233518> ?p ?o ?g. }

• W3165233518 endingPage "2180" @default.
• W3165233518 startingPage "2168" @default.
• W3165233518 abstract "Objective: Thrombus resolution is driven by leukocyte recruitment and thrombus angiogenesis. An effective inhibition of leukocyte transmigration in vitro is mediated by naturally occurring peptide Bβ 15-42 , which is a competitive inhibitor of the interaction between the N-terminus of the fibrin beta chain and vascular endothelial cadherin. We investigated the effect of Bβ 15-42 on thrombus resolution in a murine stagnant flow venous thrombosis model and studied Bβ 15-42 levels in venous thrombus of human patients. Approach and Results: We investigated 2 mouse models of subtotal inferior vena cava ligation. In the first model, we ligated the inferior vena cava. In the second model, we additionally ligated all visible inferior vena cava side and back branches. Study groups of 8 to 12 weeks old BALB/c mice were then injected intraperitoneal twice daily with 2.4 mg/kg of Bβ 15-42 , unrelated control peptide or saline. Bβ 15-42 attenuated thrombus resolution after inferior vena cava ligation. We observed decreased numbers of thrombus macrophages and microvessels and less urokinase-type plasminogen activator expression in mice that were injected with Bβ 15-42 . Mechanistic experiments demonstrated that Bβ 15-42 blocks monocyte transmigration through an endothelial cell monolayer. Measurements of Bβ 15-42 in red clot and plasma of chronic thromboembolic pulmonary hypertension cases indicated high concentrations compared with controls. Conclusions: Our data suggest that excess of the fibrin fragment Bβ 15-42 misguides thrombus resolution, presumably by inhibiting vascular endothelial cadherin-mediated leukocyte migration during early thrombus organization." @default.
• W3165233518 created "2021-06-07" @default.
• W3165233518 creator A5021661645 @default.
• W3165233518 creator A5045384871 @default.
• W3165233518 creator A5051654166 @default.
• W3165233518 creator A5055158085 @default.
• W3165233518 creator A5055470776 @default.
• W3165233518 creator A5057853711 @default.
• W3165233518 creator A5064056107 @default.
• W3165233518 creator A5082533093 @default.
• W3165233518 creator A5085530223 @default.
• W3165233518 date "2021-07-01" @default.
• W3165233518 modified "2023-09-26" @default.
• W3165233518 title "Synthetic Fibrin-Derived Bβ _15-42 Peptide Delays Thrombus Resolution in a Mouse Model" @default.
• W3165233518 cites W1571415053 @default.
• W3165233518 cites W1576673542 @default.
• W3165233518 cites W1875615097 @default.
• W3165233518 cites W1968386409 @default.
• W3165233518 cites W1985802526 @default.
• W3165233518 cites W1994749414 @default.
• W3165233518 cites W1995707037 @default.
• W3165233518 cites W2003483974 @default.
• W3165233518 cites W2007898486 @default.
• W3165233518 cites W2016734793 @default.
• W3165233518 cites W2018369906 @default.
• W3165233518 cites W2024230801 @default.
• W3165233518 cites W2028684039 @default.
• W3165233518 cites W2037199116 @default.
• W3165233518 cites W2037248386 @default.
• W3165233518 cites W2038969299 @default.
• W3165233518 cites W2053546643 @default.
• W3165233518 cites W2055152278 @default.
• W3165233518 cites W2055244243 @default.
• W3165233518 cites W2056350794 @default.
• W3165233518 cites W2061449760 @default.
• W3165233518 cites W2065756619 @default.
• W3165233518 cites W2067216597 @default.
• W3165233518 cites W2067800961 @default.
• W3165233518 cites W2071220074 @default.
• W3165233518 cites W2071602068 @default.
• W3165233518 cites W2079729964 @default.
• W3165233518 cites W2089923117 @default.
• W3165233518 cites W2099632521 @default.
• W3165233518 cites W2106810964 @default.
• W3165233518 cites W2109847117 @default.
• W3165233518 cites W2118459007 @default.
• W3165233518 cites W2132679226 @default.
• W3165233518 cites W2134053129 @default.
• W3165233518 cites W2134710242 @default.
• W3165233518 cites W2134749398 @default.
• W3165233518 cites W2136269776 @default.
• W3165233518 cites W2143914886 @default.
• W3165233518 cites W2149299331 @default.
• W3165233518 cites W2152494611 @default.
• W3165233518 cites W2156529266 @default.
• W3165233518 cites W2172191543 @default.
• W3165233518 cites W2173312558 @default.
• W3165233518 cites W2187542142 @default.
• W3165233518 cites W2269920966 @default.
• W3165233518 cites W2288709196 @default.
• W3165233518 cites W2343251287 @default.
• W3165233518 cites W2345735224 @default.
• W3165233518 cites W2396829728 @default.
• W3165233518 cites W2578853149 @default.
• W3165233518 cites W2768627450 @default.
• W3165233518 cites W2773766732 @default.
• W3165233518 cites W2965926726 @default.
• W3165233518 cites W2989854530 @default.
• W3165233518 cites W3028989873 @default.
• W3165233518 cites W3043284919 @default.
• W3165233518 cites W3113945395 @default.
• W3165233518 doi "https://doi.org/10.1161/atvbaha.121.316404" @default.
• W3165233518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34078093" @default.
• W3165233518 hasPublicationYear "2021" @default.
• W3165233518 type Work @default.
• W3165233518 sameAs 3165233518 @default.
• W3165233518 citedByCount "1" @default.
• W3165233518 countsByYear W31652335182023 @default.
• W3165233518 crossrefType "journal-article" @default.
• W3165233518 hasAuthorship W3165233518A5021661645 @default.
• W3165233518 hasAuthorship W3165233518A5045384871 @default.
• W3165233518 hasAuthorship W3165233518A5051654166 @default.
• W3165233518 hasAuthorship W3165233518A5055158085 @default.
• W3165233518 hasAuthorship W3165233518A5055470776 @default.
• W3165233518 hasAuthorship W3165233518A5057853711 @default.
• W3165233518 hasAuthorship W3165233518A5064056107 @default.
• W3165233518 hasAuthorship W3165233518A5082533093 @default.
• W3165233518 hasAuthorship W3165233518A5085530223 @default.
• W3165233518 hasBestOaLocation W31652335181 @default.
• W3165233518 hasConcept C126322002 @default.
• W3165233518 hasConcept C142724271 @default.
• W3165233518 hasConcept C179437574 @default.
• W3165233518 hasConcept C203014093 @default.
• W3165233518 hasConcept C2780011451 @default.
• W3165233518 hasConcept C2780868729 @default.
• W3165233518 hasConcept C2781362458 @default.
• W3165233518 hasConcept C2910216633 @default.
• W3165233518 hasConcept C54173615 @default.

• next