Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165269920> ?p ?o ?g. }
- W3165269920 endingPage "105689" @default.
- W3165269920 startingPage "105689" @default.
- W3165269920 abstract "Genome wide association, epidemiological, and clinical studies have established high lipoprotein(a) [Lp(a)] as a causal risk factor for atherosclerotic cardiovascular disease (ASCVD). Lp(a) is an apoB100 containing lipoprotein covalently bound to apolipoprotein(a) [apo(a)], a glycoprotein. Plasma Lp(a) levels are to a large extent determined by genetics. Its link to cardiovascular disease (CVD) may be driven by its pro-inflammatory effects, of which its association with oxidized phospholipids (oxPL) bound to Lp(a) is the most studied. Various inflammatory conditions, such as rheumatoid arthritis (RA), systemic lupus erythematosus, acquired immunodeficiency syndrome, and chronic renal failure are associated with high Lp(a) levels. In cases of RA, high Lp(a) levels are reversed by interleukin-6 receptor (IL-6R) blockade by tocilizumab, suggesting a potential role for IL-6 in regulating Lp(a) plasma levels. Elevated levels of IL-6 and IL-6R polymorphisms are associated with CVD. Therapies aimed at lowering apo(a) and thereby reducing plasma Lp(a) levels are in clinical trials. Their results will determine if reductions in apo(a) and Lp(a) decrease cardiovascular outcomes. As we enter this new arena of available treatments, there is a need to improve our understanding of mechanisms. This review will focus on the role of Lp(a) in inflammation and CVD." @default.
- W3165269920 created "2021-06-07" @default.
- W3165269920 creator A5012063139 @default.
- W3165269920 creator A5062340481 @default.
- W3165269920 date "2021-07-01" @default.
- W3165269920 modified "2023-10-03" @default.
- W3165269920 title "Beyond Lipoprotein(a) plasma measurements: Lipoprotein(a) and inflammation" @default.
- W3165269920 cites W1517965101 @default.
- W3165269920 cites W153639741 @default.
- W3165269920 cites W1578820077 @default.
- W3165269920 cites W1941429420 @default.
- W3165269920 cites W1967820629 @default.
- W3165269920 cites W1972932102 @default.
- W3165269920 cites W1978017876 @default.
- W3165269920 cites W1980729671 @default.
- W3165269920 cites W1983089921 @default.
- W3165269920 cites W1989755277 @default.
- W3165269920 cites W1990204315 @default.
- W3165269920 cites W1992495544 @default.
- W3165269920 cites W1993158654 @default.
- W3165269920 cites W1998280774 @default.
- W3165269920 cites W2001100675 @default.
- W3165269920 cites W2002146594 @default.
- W3165269920 cites W2004976342 @default.
- W3165269920 cites W2010563027 @default.
- W3165269920 cites W2020438152 @default.
- W3165269920 cites W2020556889 @default.
- W3165269920 cites W2031043834 @default.
- W3165269920 cites W2031508076 @default.
- W3165269920 cites W2032091500 @default.
- W3165269920 cites W2033883349 @default.
- W3165269920 cites W2037112459 @default.
- W3165269920 cites W2039683628 @default.
- W3165269920 cites W2047478159 @default.
- W3165269920 cites W2052911190 @default.
- W3165269920 cites W2063491068 @default.
- W3165269920 cites W2065834761 @default.
- W3165269920 cites W2070316993 @default.
- W3165269920 cites W2074284980 @default.
- W3165269920 cites W2074977347 @default.
- W3165269920 cites W2075069959 @default.
- W3165269920 cites W2076251313 @default.
- W3165269920 cites W2094744791 @default.
- W3165269920 cites W2095128549 @default.
- W3165269920 cites W2096432979 @default.
- W3165269920 cites W2098890974 @default.
- W3165269920 cites W2099437730 @default.
- W3165269920 cites W2103480977 @default.
- W3165269920 cites W2106470271 @default.
- W3165269920 cites W2109817990 @default.
- W3165269920 cites W2111095487 @default.
- W3165269920 cites W2113978145 @default.
- W3165269920 cites W2114285726 @default.
- W3165269920 cites W2116478762 @default.
- W3165269920 cites W2120689150 @default.
- W3165269920 cites W2125212735 @default.
- W3165269920 cites W2125385128 @default.
- W3165269920 cites W2130541883 @default.
- W3165269920 cites W2130696834 @default.
- W3165269920 cites W2139957955 @default.
- W3165269920 cites W2142686113 @default.
- W3165269920 cites W2143727405 @default.
- W3165269920 cites W2152119060 @default.
- W3165269920 cites W2156166356 @default.
- W3165269920 cites W2161385474 @default.
- W3165269920 cites W2161655722 @default.
- W3165269920 cites W2179100316 @default.
- W3165269920 cites W2189713131 @default.
- W3165269920 cites W2234206893 @default.
- W3165269920 cites W2311548160 @default.
- W3165269920 cites W2335128187 @default.
- W3165269920 cites W2345178212 @default.
- W3165269920 cites W2406670564 @default.
- W3165269920 cites W2416854880 @default.
- W3165269920 cites W2471143596 @default.
- W3165269920 cites W2498232546 @default.
- W3165269920 cites W2516597936 @default.
- W3165269920 cites W2522418769 @default.
- W3165269920 cites W2552067282 @default.
- W3165269920 cites W2563852152 @default.
- W3165269920 cites W2584401547 @default.
- W3165269920 cites W2589057183 @default.
- W3165269920 cites W2591643981 @default.
- W3165269920 cites W2593612000 @default.
- W3165269920 cites W2595802445 @default.
- W3165269920 cites W2607465490 @default.
- W3165269920 cites W2693333688 @default.
- W3165269920 cites W2736338239 @default.
- W3165269920 cites W2748400555 @default.
- W3165269920 cites W2752864344 @default.
- W3165269920 cites W2782889826 @default.
- W3165269920 cites W27914534 @default.
- W3165269920 cites W2796014911 @default.
- W3165269920 cites W2806643091 @default.
- W3165269920 cites W2806741586 @default.
- W3165269920 cites W2807030957 @default.
- W3165269920 cites W2809438303 @default.
- W3165269920 cites W2888384778 @default.