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• W3165280288 endingPage "103139" @default.
• W3165280288 startingPage "103139" @default.
• W3165280288 abstract "DNA double-strand breaks (DSBs) are toxic lesions triggered not only by environmental sources, but also by a large number of physiological processes. Of importance, endogenous DSBs frequently occur in genomic loci that are transcriptionally active. Recent work suggests that DSBs occurring in transcribed loci are handled by specific pathway(s) that entail local transcriptional repression, chromatin signaling, the involvement of RNA species and DSB mobility. In this Graphical Review we provide an updated view of the “Transcription-Coupled DSB Repair” (TC-DSBR) pathway(s) that are mounted at DSBs occurring in loci transcribed by RNA Polymerase I (RNAPI) or RNA Polymerase II (RNAPII), highlighting differences and common features, as well as yet unanswered questions." @default.
• W3165280288 created "2021-06-07" @default.
• W3165280288 creator A5044736831 @default.
• W3165280288 creator A5069455132 @default.
• W3165280288 creator A5074543116 @default.
• W3165280288 date "2021-08-01" @default.
• W3165280288 modified "2023-10-16" @default.
• W3165280288 title "Repair of DNA double-strand breaks in RNAPI- and RNAPII-transcribed loci" @default.
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• W3165280288 doi "https://doi.org/10.1016/j.dnarep.2021.103139" @default.
• W3165280288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34111758" @default.
• W3165280288 hasPublicationYear "2021" @default.
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