Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165284515> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3165284515 abstract "Diabetes mellitus is a disease caused by abnormalities in the pancreas due to impaired insulin secretion or the inability to use the insulin produced effectively, which treats hyperglycemia. Indonesia ranks 4 in the world with the highest number of diabetes mellitus sufferers, namely 8.4 million people, and will continue to increase to 21.2 million people in 2030. α-Amylase (alpha-1,4glucan-4-glucanohydrolase) is a catalyst hydrolyzing Alpha-1,4-glycosidic polysaccharides of starch become oligosaccharides then digested further to produce glucose. In controlling glucose in people with DMT2, it is necessary to consider the choice of oral antidiabetic drugs (OAD) because of their many side effects. The anti-diabetic activity of Sapodilla leaf extract (Manilkara zapota) has been proven to show real antidiabetic activity by showing a hypoglycemic effect. Phenolic compounds have biological activity as anti-inflammatory, antioxidant, antibacterial, antifungal, antidiabetic. This study aimed to obtain a prediction of the antidiabetic potential of the phenolic compounds of Sapodilla leaf extract (Manilkara zapota) in inhibiting the α-Amylase enzyme in type 2 DM patients. The method used in this study was to predict the pharmacokinetics of ADMET using the online pkCSM webserver. At the outset, we downloaded a copy of the test of compound SMILES using the PubChem webserver, Molecular docking using PyRx 0.8, PyMol, and Discovery Studio software. The findings suggested that the phenolic group compounds are predicted to have good absorption, distribution, metabolism, excretion, and toxicity values, and the combination of free energy values of phenolic compounds produced a synergistic effect. The bond between sitagliptin and the α-amylase enzyme was the most stable domain compared to others." @default.
- W3165284515 created "2021-06-07" @default.
- W3165284515 creator A5008230450 @default.
- W3165284515 creator A5031775263 @default.
- W3165284515 creator A5050606420 @default.
- W3165284515 creator A5076766288 @default.
- W3165284515 creator A5078718819 @default.
- W3165284515 date "2021-01-01" @default.
- W3165284515 modified "2023-09-25" @default.
- W3165284515 title "Potential compounds phenolic group sawo leaves (Manilkara zapota) as an α-amylase inhibitor in type 2 diabetes mellitus by in silico" @default.
- W3165284515 cites W1589514561 @default.
- W3165284515 cites W1968361256 @default.
- W3165284515 cites W2015594070 @default.
- W3165284515 cites W2024212561 @default.
- W3165284515 cites W2049702067 @default.
- W3165284515 cites W2070516699 @default.
- W3165284515 cites W2080203751 @default.
- W3165284515 cites W2603804762 @default.
- W3165284515 cites W2759298922 @default.
- W3165284515 cites W2805340289 @default.
- W3165284515 cites W4233964995 @default.
- W3165284515 doi "https://doi.org/10.1063/5.0053087" @default.
- W3165284515 hasPublicationYear "2021" @default.
- W3165284515 type Work @default.
- W3165284515 sameAs 3165284515 @default.
- W3165284515 citedByCount "1" @default.
- W3165284515 countsByYear W31652845152022 @default.
- W3165284515 crossrefType "proceedings-article" @default.
- W3165284515 hasAuthorship W3165284515A5008230450 @default.
- W3165284515 hasAuthorship W3165284515A5031775263 @default.
- W3165284515 hasAuthorship W3165284515A5050606420 @default.
- W3165284515 hasAuthorship W3165284515A5076766288 @default.
- W3165284515 hasAuthorship W3165284515A5078718819 @default.
- W3165284515 hasBestOaLocation W31652845151 @default.
- W3165284515 hasConcept C126322002 @default.
- W3165284515 hasConcept C134018914 @default.
- W3165284515 hasConcept C16005928 @default.
- W3165284515 hasConcept C170835558 @default.
- W3165284515 hasConcept C181199279 @default.
- W3165284515 hasConcept C185592680 @default.
- W3165284515 hasConcept C2778854520 @default.
- W3165284515 hasConcept C2779306644 @default.
- W3165284515 hasConcept C2779548794 @default.
- W3165284515 hasConcept C2910068830 @default.
- W3165284515 hasConcept C529335014 @default.
- W3165284515 hasConcept C55493867 @default.
- W3165284515 hasConcept C555293320 @default.
- W3165284515 hasConcept C556039675 @default.
- W3165284515 hasConcept C71924100 @default.
- W3165284515 hasConceptScore W3165284515C126322002 @default.
- W3165284515 hasConceptScore W3165284515C134018914 @default.
- W3165284515 hasConceptScore W3165284515C16005928 @default.
- W3165284515 hasConceptScore W3165284515C170835558 @default.
- W3165284515 hasConceptScore W3165284515C181199279 @default.
- W3165284515 hasConceptScore W3165284515C185592680 @default.
- W3165284515 hasConceptScore W3165284515C2778854520 @default.
- W3165284515 hasConceptScore W3165284515C2779306644 @default.
- W3165284515 hasConceptScore W3165284515C2779548794 @default.
- W3165284515 hasConceptScore W3165284515C2910068830 @default.
- W3165284515 hasConceptScore W3165284515C529335014 @default.
- W3165284515 hasConceptScore W3165284515C55493867 @default.
- W3165284515 hasConceptScore W3165284515C555293320 @default.
- W3165284515 hasConceptScore W3165284515C556039675 @default.
- W3165284515 hasConceptScore W3165284515C71924100 @default.
- W3165284515 hasLocation W31652845151 @default.
- W3165284515 hasOpenAccess W3165284515 @default.
- W3165284515 hasPrimaryLocation W31652845151 @default.
- W3165284515 hasRelatedWork W2059993571 @default.
- W3165284515 hasRelatedWork W2108752660 @default.
- W3165284515 hasRelatedWork W2130020611 @default.
- W3165284515 hasRelatedWork W2368557553 @default.
- W3165284515 hasRelatedWork W2400273222 @default.
- W3165284515 hasRelatedWork W2411311794 @default.
- W3165284515 hasRelatedWork W2413476983 @default.
- W3165284515 hasRelatedWork W268700829 @default.
- W3165284515 hasRelatedWork W3165284515 @default.
- W3165284515 hasRelatedWork W335503351 @default.
- W3165284515 isParatext "false" @default.
- W3165284515 isRetracted "false" @default.
- W3165284515 magId "3165284515" @default.
- W3165284515 workType "article" @default.