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- W3165301831 endingPage "8837" @default.
- W3165301831 startingPage "8826" @default.
- W3165301831 abstract "How to deliver nitric oxide (NO) to a physiological target and control its release quantitatively is a key issue for biomedical applications. Here, a water-soluble nitrosylruthenium complex, [(CH3)4N][RuCl3(5cqn)(NO)] (H5cqn = 5-chloro-8-quinoline), was synthesized, and its structure was confirmed with 1H NMR and X-ray crystal diffraction. Photoinduced NO release was investigated with time-resolved Fourier transform infrared and electron paramagnetic resonance (EPR) spectroscopies. The binding constant of the [RuCl3(5cqn)(NO)]− complex with human serum albumin (HSA) was determined by fluorescence spectroscopy, and the binding mode was identified by X-ray crystallography of the HSA and Ru-NO complex adduct. The crystal structure reveals that two molecules of the Ru-NO complex are located in the subdomain IB, which is one of the major drug binding regions of HSA. The chemical structures of the Ru complexes were [RuCl3(5cqn)(NO)]− and [RuCl3(Glycerin)NO]−, in which the electron densities for all ligands to Ru are unambiguously identified. EPR spin-trapping data showed that photoirradiation triggered NO radical generation from the HSA complex adduct. Moreover, the near-infrared image of exogenous NO from the nitrosylruthenium complex in living cells was observed using a NO-selective fluorescent probe. This study provides a strategy to design an appropriate delivery system to transport NO and metallodrugs in vivo for potential applications." @default.
- W3165301831 created "2021-06-07" @default.
- W3165301831 creator A5008986797 @default.
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- W3165301831 creator A5022432524 @default.
- W3165301831 creator A5041339619 @default.
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- W3165301831 creator A5070661061 @default.
- W3165301831 creator A5082013054 @default.
- W3165301831 creator A5086690584 @default.
- W3165301831 date "2021-06-01" @default.
- W3165301831 modified "2023-10-16" @default.
- W3165301831 title "Structural and Photodynamic Studies on Nitrosylruthenium-Complexed Serum Albumin as a Delivery System for Controlled Nitric Oxide Release" @default.
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