FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165308002> ?p ?o ?g. }

• W3165308002 endingPage "73" @default.
• W3165308002 startingPage "70" @default.
• W3165308002 abstract "Introduction Experimental stroke studies suggest an influence of the time of day of stroke onset on infarct progression. Whether this holds true after human stroke is unknown, but would have implications for the design of randomised controlled trials, especially those on neuroprotection. Methods We pooled data from 583 patients with anterior large-vessel occlusion stroke from three prospectively recruited cohorts. Ischaemic core and penumbra volumes were determined with CT perfusion using automated thresholds. Core growth was calculated as the ratio of core volume and onset-to-imaging time. To determine circadian rhythmicity, we applied multivariable linear and sinusoidal regression analysis adjusting for potential baseline confounders. Results Patients with symptom onset at night showed larger ischaemic core volumes on admission compared with patients with onset during the day (median, 40.2 mL vs 33.8 mL), also in adjusted analyses (p=0.008). Sinusoidal analysis indicated a peak of core volumes with onset at 11pm. Core growth was faster at night compared with day onset (adjusted p=0.01), especially for shorter onset-to-imaging times. In contrast, penumbra volumes did not change across the 24-hour cycle. Discussion These results suggest that human infarct progression varies across the 24-hour cycle with potential implications for the design and interpretation of neuroprotection trials." @default.
• W3165308002 created "2021-06-07" @default.
• W3165308002 creator A5000216110 @default.
• W3165308002 creator A5032736160 @default.
• W3165308002 creator A5033337192 @default.
• W3165308002 creator A5035777659 @default.
• W3165308002 creator A5036902737 @default.
• W3165308002 creator A5037086238 @default.
• W3165308002 creator A5057700552 @default.
• W3165308002 creator A5058748052 @default.
• W3165308002 creator A5061123357 @default.
• W3165308002 creator A5066149850 @default.
• W3165308002 creator A5068808600 @default.
• W3165308002 creator A5071144602 @default.
• W3165308002 creator A5071803972 @default.
• W3165308002 date "2021-05-26" @default.
• W3165308002 modified "2023-10-16" @default.
• W3165308002 title "Circadian rhythm of ischaemic core progression in human stroke" @default.
• W3165308002 cites W1977940934 @default.
• W3165308002 cites W2003062381 @default.
• W3165308002 cites W2056526470 @default.
• W3165308002 cites W2148656951 @default.
• W3165308002 cites W2406604088 @default.
• W3165308002 cites W2489968831 @default.
• W3165308002 cites W2913280908 @default.
• W3165308002 cites W2969732888 @default.
• W3165308002 cites W3007594181 @default.
• W3165308002 cites W3032857192 @default.
• W3165308002 cites W3087376334 @default.
• W3165308002 doi "https://doi.org/10.1136/jnnp-2021-326072" @default.
• W3165308002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34039629" @default.
• W3165308002 hasPublicationYear "2021" @default.
• W3165308002 type Work @default.
• W3165308002 sameAs 3165308002 @default.
• W3165308002 citedByCount "18" @default.
• W3165308002 countsByYear W31653080022021 @default.
• W3165308002 countsByYear W31653080022022 @default.
• W3165308002 countsByYear W31653080022023 @default.
• W3165308002 crossrefType "journal-article" @default.
• W3165308002 hasAuthorship W3165308002A5000216110 @default.
• W3165308002 hasAuthorship W3165308002A5032736160 @default.
• W3165308002 hasAuthorship W3165308002A5033337192 @default.
• W3165308002 hasAuthorship W3165308002A5035777659 @default.
• W3165308002 hasAuthorship W3165308002A5036902737 @default.
• W3165308002 hasAuthorship W3165308002A5037086238 @default.
• W3165308002 hasAuthorship W3165308002A5057700552 @default.
• W3165308002 hasAuthorship W3165308002A5058748052 @default.
• W3165308002 hasAuthorship W3165308002A5061123357 @default.
• W3165308002 hasAuthorship W3165308002A5066149850 @default.
• W3165308002 hasAuthorship W3165308002A5068808600 @default.
• W3165308002 hasAuthorship W3165308002A5071144602 @default.
• W3165308002 hasAuthorship W3165308002A5071803972 @default.
• W3165308002 hasConcept C121446783 @default.
• W3165308002 hasConcept C126322002 @default.
• W3165308002 hasConcept C127413603 @default.
• W3165308002 hasConcept C159985019 @default.
• W3165308002 hasConcept C164705383 @default.
• W3165308002 hasConcept C192562407 @default.
• W3165308002 hasConcept C2164484 @default.
• W3165308002 hasConcept C25498285 @default.
• W3165308002 hasConcept C2780577055 @default.
• W3165308002 hasConcept C2780645631 @default.
• W3165308002 hasConcept C3018755981 @default.
• W3165308002 hasConcept C535046627 @default.
• W3165308002 hasConcept C541997718 @default.
• W3165308002 hasConcept C71924100 @default.
• W3165308002 hasConcept C77350462 @default.
• W3165308002 hasConcept C78519656 @default.
• W3165308002 hasConceptScore W3165308002C121446783 @default.
• W3165308002 hasConceptScore W3165308002C126322002 @default.
• W3165308002 hasConceptScore W3165308002C127413603 @default.
• W3165308002 hasConceptScore W3165308002C159985019 @default.
• W3165308002 hasConceptScore W3165308002C164705383 @default.
• W3165308002 hasConceptScore W3165308002C192562407 @default.
• W3165308002 hasConceptScore W3165308002C2164484 @default.
• W3165308002 hasConceptScore W3165308002C25498285 @default.
• W3165308002 hasConceptScore W3165308002C2780577055 @default.
• W3165308002 hasConceptScore W3165308002C2780645631 @default.
• W3165308002 hasConceptScore W3165308002C3018755981 @default.
• W3165308002 hasConceptScore W3165308002C535046627 @default.
• W3165308002 hasConceptScore W3165308002C541997718 @default.
• W3165308002 hasConceptScore W3165308002C71924100 @default.
• W3165308002 hasConceptScore W3165308002C77350462 @default.
• W3165308002 hasConceptScore W3165308002C78519656 @default.
• W3165308002 hasFunder F4320316266 @default.
• W3165308002 hasIssue "1" @default.
• W3165308002 hasLocation W31653080021 @default.
• W3165308002 hasLocation W31653080022 @default.
• W3165308002 hasOpenAccess W3165308002 @default.
• W3165308002 hasPrimaryLocation W31653080021 @default.
• W3165308002 hasRelatedWork W1965655136 @default.
• W3165308002 hasRelatedWork W2007381770 @default.
• W3165308002 hasRelatedWork W2018896757 @default.
• W3165308002 hasRelatedWork W2051762050 @default.
• W3165308002 hasRelatedWork W2053137874 @default.
• W3165308002 hasRelatedWork W2080370764 @default.
• W3165308002 hasRelatedWork W2770272869 @default.
• W3165308002 hasRelatedWork W4237065776 @default.

• next