Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165344697> ?p ?o ?g. }
- W3165344697 endingPage "120902" @default.
- W3165344697 startingPage "120902" @default.
- W3165344697 abstract "Activated fibroblasts are critical contributors to renal interstitial fibrosis thus becoming the cellular target for fibrosis treatment. Previously, microRNA 29 b (miR-29 b) is shown to be down-regulated in various animal models of renal fibrosis. Herein, we describe a facile strategy to achieve localized and sustained delivery of therapeutic microRNA to the kidney via a host-guest supramolecular hydrogel. Specifically, cationic bovine serum albumin is used to complex with miR-29 b to afford nanocomplexes (cBSA/miR-29 b), which is proven to specifically inhibit fibroblast activation in a dose-dependent manner in vitro. Following unilateral ureteral obstruction in mice, a single injection of the hydrogel loaded with cBSA/miR-29 b in vivo, significantly down-regulated proteins and genes related to fibrosis for up to 21 days without affecting the normal liver or kidney functions. Overall, the localized delivery of cBSA/miR-29 b via a host-guest supramolecular hydrogel represents a safe and effective intervention strategy to delay and reverse the progression of interstitial renal fibrosis." @default.
- W3165344697 created "2021-06-07" @default.
- W3165344697 creator A5001421484 @default.
- W3165344697 creator A5003372705 @default.
- W3165344697 creator A5012690617 @default.
- W3165344697 creator A5028833857 @default.
- W3165344697 creator A5048643609 @default.
- W3165344697 creator A5059862135 @default.
- W3165344697 creator A5081643835 @default.
- W3165344697 date "2021-08-01" @default.
- W3165344697 modified "2023-10-18" @default.
- W3165344697 title "Extended-release of therapeutic microRNA via a host-guest supramolecular hydrogel to locally alleviate renal interstitial fibrosis" @default.
- W3165344697 cites W1965895613 @default.
- W3165344697 cites W1969136202 @default.
- W3165344697 cites W1969204556 @default.
- W3165344697 cites W1971300919 @default.
- W3165344697 cites W1981480973 @default.
- W3165344697 cites W2000136129 @default.
- W3165344697 cites W2002839070 @default.
- W3165344697 cites W2004006890 @default.
- W3165344697 cites W2013888190 @default.
- W3165344697 cites W2020297982 @default.
- W3165344697 cites W2020650391 @default.
- W3165344697 cites W2033457930 @default.
- W3165344697 cites W2033974379 @default.
- W3165344697 cites W2034947704 @default.
- W3165344697 cites W2041965025 @default.
- W3165344697 cites W2041998484 @default.
- W3165344697 cites W2045803893 @default.
- W3165344697 cites W2051696368 @default.
- W3165344697 cites W2062398289 @default.
- W3165344697 cites W2064767074 @default.
- W3165344697 cites W2070270336 @default.
- W3165344697 cites W2074630757 @default.
- W3165344697 cites W2078657995 @default.
- W3165344697 cites W2082511674 @default.
- W3165344697 cites W2085038604 @default.
- W3165344697 cites W2086602436 @default.
- W3165344697 cites W2087726367 @default.
- W3165344697 cites W2091096046 @default.
- W3165344697 cites W2120055234 @default.
- W3165344697 cites W2121014368 @default.
- W3165344697 cites W2137112302 @default.
- W3165344697 cites W2138980047 @default.
- W3165344697 cites W2151119093 @default.
- W3165344697 cites W2154742224 @default.
- W3165344697 cites W2155290141 @default.
- W3165344697 cites W2233523867 @default.
- W3165344697 cites W2288759932 @default.
- W3165344697 cites W2315934024 @default.
- W3165344697 cites W2323570170 @default.
- W3165344697 cites W2328605846 @default.
- W3165344697 cites W2338167986 @default.
- W3165344697 cites W2401600644 @default.
- W3165344697 cites W2519576106 @default.
- W3165344697 cites W2536493540 @default.
- W3165344697 cites W2559284385 @default.
- W3165344697 cites W2607179358 @default.
- W3165344697 cites W2729309989 @default.
- W3165344697 cites W2743806458 @default.
- W3165344697 cites W2794598161 @default.
- W3165344697 cites W2801175906 @default.
- W3165344697 cites W2884313348 @default.
- W3165344697 cites W2922194438 @default.
- W3165344697 cites W2965988186 @default.
- W3165344697 cites W2983618915 @default.
- W3165344697 cites W2990991757 @default.
- W3165344697 cites W3005627128 @default.
- W3165344697 cites W3005957464 @default.
- W3165344697 cites W3093332769 @default.
- W3165344697 cites W3118678175 @default.
- W3165344697 cites W4213191201 @default.
- W3165344697 cites W4244523227 @default.
- W3165344697 doi "https://doi.org/10.1016/j.biomaterials.2021.120902" @default.
- W3165344697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34087588" @default.
- W3165344697 hasPublicationYear "2021" @default.
- W3165344697 type Work @default.
- W3165344697 sameAs 3165344697 @default.
- W3165344697 citedByCount "11" @default.
- W3165344697 countsByYear W31653446972022 @default.
- W3165344697 countsByYear W31653446972023 @default.
- W3165344697 crossrefType "journal-article" @default.
- W3165344697 hasAuthorship W3165344697A5001421484 @default.
- W3165344697 hasAuthorship W3165344697A5003372705 @default.
- W3165344697 hasAuthorship W3165344697A5012690617 @default.
- W3165344697 hasAuthorship W3165344697A5028833857 @default.
- W3165344697 hasAuthorship W3165344697A5048643609 @default.
- W3165344697 hasAuthorship W3165344697A5059862135 @default.
- W3165344697 hasAuthorship W3165344697A5081643835 @default.
- W3165344697 hasConcept C104317684 @default.
- W3165344697 hasConcept C115624301 @default.
- W3165344697 hasConcept C126322002 @default.
- W3165344697 hasConcept C142724271 @default.
- W3165344697 hasConcept C145059251 @default.
- W3165344697 hasConcept C150903083 @default.
- W3165344697 hasConcept C185592680 @default.
- W3165344697 hasConcept C192562407 @default.
- W3165344697 hasConcept C202751555 @default.