FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165368567> ?p ?o ?g. }

• W3165368567 abstract "Asiatic acid (AA) has been shown to induce apoptotic death in a range of cancers, but the mechanisms whereby it can inhibit tongue cancer growth have yet to be clarified. Herein, we explored the effects of AA on tongue cancer cells and found that it induced their apoptotic death in vitro and in vivo, while additionally impairing xenograft tumor growth in vivo. From a mechanistic perspective, AA treatment was associated with increases in levels of calcium and the calcium- dependent protease calpain, and it further induced endoplasmic reticulum (ER) stress and consequent Grp78-related IRE1α and JNK phosphorylation, ultimately driving caspase-3 activation and apoptotic death. Together, these results highlight AA as a promising tool for the therapeutic treatment of tongue cancer in clinical practice." @default.
• W3165368567 created "2021-06-07" @default.
• W3165368567 creator A5004607409 @default.
• W3165368567 creator A5007408091 @default.
• W3165368567 creator A5018305440 @default.
• W3165368567 creator A5027659314 @default.
• W3165368567 creator A5052012434 @default.
• W3165368567 creator A5083863507 @default.
• W3165368567 creator A5091073331 @default.
• W3165368567 date "2021-05-26" @default.
• W3165368567 modified "2023-10-07" @default.
• W3165368567 title "Asiatic Acid Induces Endoplasmic Reticulum Stress and Activates the Grp78/IRE1α/JNK and Calpain Pathways to Inhibit Tongue Cancer Growth" @default.
• W3165368567 cites W1781516580 @default.
• W3165368567 cites W1823288226 @default.
• W3165368567 cites W2000305671 @default.
• W3165368567 cites W2012166934 @default.
• W3165368567 cites W2077209088 @default.
• W3165368567 cites W2080901528 @default.
• W3165368567 cites W2085933321 @default.
• W3165368567 cites W2115205812 @default.
• W3165368567 cites W2119970046 @default.
• W3165368567 cites W2145722638 @default.
• W3165368567 cites W2147950253 @default.
• W3165368567 cites W2155147247 @default.
• W3165368567 cites W2161277359 @default.
• W3165368567 cites W2214858649 @default.
• W3165368567 cites W2297663388 @default.
• W3165368567 cites W2418828468 @default.
• W3165368567 cites W2462865792 @default.
• W3165368567 cites W2520852005 @default.
• W3165368567 cites W2576425501 @default.
• W3165368567 cites W2589060305 @default.
• W3165368567 cites W2742984980 @default.
• W3165368567 cites W2766521821 @default.
• W3165368567 cites W2766900039 @default.
• W3165368567 cites W2809220713 @default.
• W3165368567 cites W2883058578 @default.
• W3165368567 cites W2886662737 @default.
• W3165368567 cites W2890537385 @default.
• W3165368567 cites W2992241665 @default.
• W3165368567 doi "https://doi.org/10.3389/fphar.2021.690612" @default.
• W3165368567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8187906" @default.
• W3165368567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34122116" @default.
• W3165368567 hasPublicationYear "2021" @default.
• W3165368567 type Work @default.
• W3165368567 sameAs 3165368567 @default.
• W3165368567 citedByCount "6" @default.
• W3165368567 countsByYear W31653685672021 @default.
• W3165368567 countsByYear W31653685672022 @default.
• W3165368567 countsByYear W31653685672023 @default.
• W3165368567 crossrefType "journal-article" @default.
• W3165368567 hasAuthorship W3165368567A5004607409 @default.
• W3165368567 hasAuthorship W3165368567A5007408091 @default.
• W3165368567 hasAuthorship W3165368567A5018305440 @default.
• W3165368567 hasAuthorship W3165368567A5027659314 @default.
• W3165368567 hasAuthorship W3165368567A5052012434 @default.
• W3165368567 hasAuthorship W3165368567A5083863507 @default.
• W3165368567 hasAuthorship W3165368567A5091073331 @default.
• W3165368567 hasBestOaLocation W31653685671 @default.
• W3165368567 hasConcept C121608353 @default.
• W3165368567 hasConcept C126322002 @default.
• W3165368567 hasConcept C139447449 @default.
• W3165368567 hasConcept C142724271 @default.
• W3165368567 hasConcept C150903083 @default.
• W3165368567 hasConcept C158617107 @default.
• W3165368567 hasConcept C181199279 @default.
• W3165368567 hasConcept C185592680 @default.
• W3165368567 hasConcept C190283241 @default.
• W3165368567 hasConcept C207001950 @default.
• W3165368567 hasConcept C2779744641 @default.
• W3165368567 hasConcept C31573885 @default.
• W3165368567 hasConcept C502942594 @default.
• W3165368567 hasConcept C519063684 @default.
• W3165368567 hasConcept C55493867 @default.
• W3165368567 hasConcept C56928146 @default.
• W3165368567 hasConcept C71924100 @default.
• W3165368567 hasConcept C86803240 @default.
• W3165368567 hasConcept C95444343 @default.
• W3165368567 hasConcept C96232424 @default.
• W3165368567 hasConcept C98424977 @default.
• W3165368567 hasConceptScore W3165368567C121608353 @default.
• W3165368567 hasConceptScore W3165368567C126322002 @default.
• W3165368567 hasConceptScore W3165368567C139447449 @default.
• W3165368567 hasConceptScore W3165368567C142724271 @default.
• W3165368567 hasConceptScore W3165368567C150903083 @default.
• W3165368567 hasConceptScore W3165368567C158617107 @default.
• W3165368567 hasConceptScore W3165368567C181199279 @default.
• W3165368567 hasConceptScore W3165368567C185592680 @default.
• W3165368567 hasConceptScore W3165368567C190283241 @default.
• W3165368567 hasConceptScore W3165368567C207001950 @default.
• W3165368567 hasConceptScore W3165368567C2779744641 @default.
• W3165368567 hasConceptScore W3165368567C31573885 @default.
• W3165368567 hasConceptScore W3165368567C502942594 @default.
• W3165368567 hasConceptScore W3165368567C519063684 @default.
• W3165368567 hasConceptScore W3165368567C55493867 @default.
• W3165368567 hasConceptScore W3165368567C56928146 @default.
• W3165368567 hasConceptScore W3165368567C71924100 @default.
• W3165368567 hasConceptScore W3165368567C86803240 @default.
• W3165368567 hasConceptScore W3165368567C95444343 @default.
• W3165368567 hasConceptScore W3165368567C96232424 @default.

• next