FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165392203> ?p ?o ?g. }

• W3165392203 endingPage "1658" @default.
• W3165392203 startingPage "1653" @default.
• W3165392203 abstract "Background: Transducin-like enhancer of split 1 (TLE1( is a member of the TLE family of transcriptional co-repressors that control the transcription of a wide range of genes. The aim of this study was to evaluate the prognostic role of TLE1 gene expression in patients with T-cell acute lymphoblastic leukemia (T-ALL). Method: This study was conducted on 97 newly diagnosed T-ALL patients admitted to the Mansoura University oncology center (59 males and 38 females) with median age (33 years) in addition to 102 apparently healthy individuals served as a control group. TLE1 gene expression was measured in both patients and control groups by real time – PCR. The calculation of relative gene expression was done using the ΔΔCt method. Results: TEL1 gene expression was significantly down regulated in T-ALL cases (median 2.83) as compared to controls (median 84.65) (p < 0.001). The low TEL1 gene expression was significantly associated with CNS infiltration, non-remission and higher relapse rate (p < 0.001, 0.001 and 0.023 respectively). Likewise, Low TEL1 gene expression was significantly associated with shorter OS and DFS (P= 0.012 and 0.011 respectively). Furthermore, Low TEL1 gene expression was considered as risk predictor of relapse with OR 3.636(CI.1.422-9.295) (P =0.007); and OR 0.803(CI. 0.609-0.96) (P=0.021) and independent predictor of T-ALL patient’s outcome with OR 0.619 (CI. 0.44-0.872) (P=0.006). Conclusion: TLE1 gene expression was significantly down regulated in T-ALL cases as compared with controls. Low TLE1 expression is independent predictor of the T-ALL patient’s outcome." @default.
• W3165392203 created "2021-06-07" @default.
• W3165392203 creator A5010395760 @default.
• W3165392203 creator A5012325703 @default.
• W3165392203 creator A5016017704 @default.
• W3165392203 creator A5039168066 @default.
• W3165392203 creator A5061498159 @default.
• W3165392203 creator A5075106082 @default.
• W3165392203 creator A5088319965 @default.
• W3165392203 date "2021-05-01" @default.
• W3165392203 modified "2023-09-27" @default.
• W3165392203 title "Prognostic Value of TLE1 Gene Expression in Patients with T-cell Acute Lymphoblastic Leukemia" @default.
• W3165392203 cites W1510801288 @default.
• W3165392203 cites W1595924202 @default.
• W3165392203 cites W180705069 @default.
• W3165392203 cites W1862517694 @default.
• W3165392203 cites W1879221139 @default.
• W3165392203 cites W1982769068 @default.
• W3165392203 cites W1987294127 @default.
• W3165392203 cites W1991103421 @default.
• W3165392203 cites W2016701073 @default.
• W3165392203 cites W2023943187 @default.
• W3165392203 cites W2030843629 @default.
• W3165392203 cites W2037142203 @default.
• W3165392203 cites W2037690521 @default.
• W3165392203 cites W2087484885 @default.
• W3165392203 cites W2088690410 @default.
• W3165392203 cites W2097035697 @default.
• W3165392203 cites W2108771261 @default.
• W3165392203 cites W2255106017 @default.
• W3165392203 cites W2337202147 @default.
• W3165392203 cites W2557106339 @default.
• W3165392203 cites W2599394520 @default.
• W3165392203 cites W2725970815 @default.
• W3165392203 cites W2893586462 @default.
• W3165392203 cites W2943589430 @default.
• W3165392203 cites W2979616283 @default.
• W3165392203 cites W3023027661 @default.
• W3165392203 doi "https://doi.org/10.31557/apjcp.2021.22.5.1653" @default.
• W3165392203 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8408389" @default.
• W3165392203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34048198" @default.
• W3165392203 hasPublicationYear "2021" @default.
• W3165392203 type Work @default.
• W3165392203 sameAs 3165392203 @default.
• W3165392203 citedByCount "3" @default.
• W3165392203 countsByYear W31653922032022 @default.
• W3165392203 countsByYear W31653922032023 @default.
• W3165392203 crossrefType "journal-article" @default.
• W3165392203 hasAuthorship W3165392203A5010395760 @default.
• W3165392203 hasAuthorship W3165392203A5012325703 @default.
• W3165392203 hasAuthorship W3165392203A5016017704 @default.
• W3165392203 hasAuthorship W3165392203A5039168066 @default.
• W3165392203 hasAuthorship W3165392203A5061498159 @default.
• W3165392203 hasAuthorship W3165392203A5075106082 @default.
• W3165392203 hasAuthorship W3165392203A5088319965 @default.
• W3165392203 hasBestOaLocation W31653922031 @default.
• W3165392203 hasConcept C104317684 @default.
• W3165392203 hasConcept C126322002 @default.
• W3165392203 hasConcept C143998085 @default.
• W3165392203 hasConcept C150194340 @default.
• W3165392203 hasConcept C203014093 @default.
• W3165392203 hasConcept C2778461978 @default.
• W3165392203 hasConcept C2909962599 @default.
• W3165392203 hasConcept C502942594 @default.
• W3165392203 hasConcept C54355233 @default.
• W3165392203 hasConcept C71924100 @default.
• W3165392203 hasConcept C86803240 @default.
• W3165392203 hasConcept C90924648 @default.
• W3165392203 hasConceptScore W3165392203C104317684 @default.
• W3165392203 hasConceptScore W3165392203C126322002 @default.
• W3165392203 hasConceptScore W3165392203C143998085 @default.
• W3165392203 hasConceptScore W3165392203C150194340 @default.
• W3165392203 hasConceptScore W3165392203C203014093 @default.
• W3165392203 hasConceptScore W3165392203C2778461978 @default.
• W3165392203 hasConceptScore W3165392203C2909962599 @default.
• W3165392203 hasConceptScore W3165392203C502942594 @default.
• W3165392203 hasConceptScore W3165392203C54355233 @default.
• W3165392203 hasConceptScore W3165392203C71924100 @default.
• W3165392203 hasConceptScore W3165392203C86803240 @default.
• W3165392203 hasConceptScore W3165392203C90924648 @default.
• W3165392203 hasIssue "5" @default.
• W3165392203 hasLocation W31653922031 @default.
• W3165392203 hasOpenAccess W3165392203 @default.
• W3165392203 hasPrimaryLocation W31653922031 @default.
• W3165392203 hasRelatedWork W1672177754 @default.
• W3165392203 hasRelatedWork W2357355733 @default.
• W3165392203 hasRelatedWork W2407161884 @default.
• W3165392203 hasRelatedWork W2410889947 @default.
• W3165392203 hasRelatedWork W2429291258 @default.
• W3165392203 hasRelatedWork W2724221850 @default.
• W3165392203 hasRelatedWork W2770032321 @default.
• W3165392203 hasRelatedWork W4249127011 @default.
• W3165392203 hasRelatedWork W4322703989 @default.
• W3165392203 hasRelatedWork W4322706357 @default.
• W3165392203 hasVolume "22" @default.
• W3165392203 isParatext "false" @default.
• W3165392203 isRetracted "false" @default.
• W3165392203 magId "3165392203" @default.

• next