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• W3165455417 abstract "Super enhancer (SE) is a cluster of enhancers that has a stronger ability to promote transcription compared to the typical enhancer (TE). Similar to TE, which can transcribe enhancer RNA (eRNA), SE produces super enhancer RNA (seRNA). The activation of SE is cell and tissue-specific, and the SE-associated genes are mostly linked to the cell fate. This is demonstrated by the important role-played by SE in the embryonic stem cell (ESC) and multiple cancer development. SeRNA regulates transcription in both cis and trans configuration, and those located in the cytoplasm mediates various cell activities. However, the functions of seRNAs are unclear, and most of them have a synergistic effect with SE and SE-associated genes. In this mini review, we summarized the mechanisms of seRNA and functions of both SE and seRNA." @default.
• W3165455417 created "2021-06-07" @default.
• W3165455417 creator A5013680342 @default.
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• W3165455417 date "2021-05-24" @default.
• W3165455417 modified "2023-09-25" @default.
• W3165455417 title "The mechanism and function of super enhancer <scp>RNA</scp>" @default.
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• W3165455417 doi "https://doi.org/10.1002/dvg.23422" @default.
• W3165455417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34028961" @default.
• W3165455417 hasPublicationYear "2021" @default.
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