Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165514303> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W3165514303 abstract "Abstract BackgroundExtraction of mandibular third molars is one of the most commonly performed oral surgical procedures, and non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management. Oral administration of NSAIDs produces various adverse events such as gastrointestinal disorders, renal and hepatic dysfunction, and platelet dysfunction. Topical use of analgesics has been proposed as an alternative to oral and injectable medications to safely improve postoperative pain relief. We will conduct a single-center, placebo-controlled, double-blind, randomized crossover trial to assess the pain-relieving effect of an ibuprofen-containing gargle in patients undergoing extraction of mandibular third molars in comparison with a placebo gargle.MethodsThis study will be performed at Kobe University Hospital. Participants (n = 40) will be randomized equally to one of two groups. The IP group will receive ibuprofen gargle on postoperative day (POD) 1 and placebo gargle on POD 2. The PI group will receive placebo gargle on POD 1 and ibuprofen gargle on POD 2. Both groups will receive ibuprofen gargle on PODs 3 to 5 at least once daily. The primary objective is to estimate the within-subject difference in a visual analogue scale (VAS) before and 5 minutes after use of ibuprofen or placebo gargle on PODs 1 and 2. The secondary objectives are to estimate the within-subject difference in ΔVAS before and 15 minutes after use of ibuprofen or placebo gargle on PODs 1 and 2, the ΔVAS before and after 5 or 15 minutes of use of ibuprofen gargle on PODs 3 to 5, the overall effectiveness (self-completion, five scales) on PODs 1 to 5, the daily frequency of use (ibuprofen or placebo gargle and analgesics) on PODs 1 to 7, and the occurrence of adverse events.DiscussionThis will be the first well-designed clinical study to evaluate the efficacy of ibuprofen gargle for relieving postoperative pain after extraction of mandibular third molars. This trial will provide exploratory evidence of the efficacy and safety of ibuprofen gargle for pain reduction after mandibular third molar extraction.Trial registrationJapan Registry of Clinical Trials (jRCT) identifier: jRCTs051210022. Registered on 10 May 2021." @default.
- W3165514303 created "2021-06-07" @default.
- W3165514303 creator A5021692073 @default.
- W3165514303 creator A5042268936 @default.
- W3165514303 creator A5059944980 @default.
- W3165514303 creator A5061970264 @default.
- W3165514303 creator A5073989109 @default.
- W3165514303 creator A5088884486 @default.
- W3165514303 creator A5090478034 @default.
- W3165514303 date "2021-05-20" @default.
- W3165514303 modified "2023-10-14" @default.
- W3165514303 title "Efficacy of Ibuprofen Gargle for Postoperative Pain After Mandibular Third Molar Extraction: A Phase II, Placebo-Controlled, Double-Blind, Randomized Crossover Trial" @default.
- W3165514303 doi "https://doi.org/10.21203/rs.3.rs-535098/v1" @default.
- W3165514303 hasPublicationYear "2021" @default.
- W3165514303 type Work @default.
- W3165514303 sameAs 3165514303 @default.
- W3165514303 citedByCount "0" @default.
- W3165514303 crossrefType "posted-content" @default.
- W3165514303 hasAuthorship W3165514303A5021692073 @default.
- W3165514303 hasAuthorship W3165514303A5042268936 @default.
- W3165514303 hasAuthorship W3165514303A5059944980 @default.
- W3165514303 hasAuthorship W3165514303A5061970264 @default.
- W3165514303 hasAuthorship W3165514303A5073989109 @default.
- W3165514303 hasAuthorship W3165514303A5088884486 @default.
- W3165514303 hasAuthorship W3165514303A5090478034 @default.
- W3165514303 hasBestOaLocation W31655143031 @default.
- W3165514303 hasConcept C126322002 @default.
- W3165514303 hasConcept C141071460 @default.
- W3165514303 hasConcept C14184104 @default.
- W3165514303 hasConcept C142724271 @default.
- W3165514303 hasConcept C168563851 @default.
- W3165514303 hasConcept C197934379 @default.
- W3165514303 hasConcept C199343813 @default.
- W3165514303 hasConcept C202271784 @default.
- W3165514303 hasConcept C204787440 @default.
- W3165514303 hasConcept C27081682 @default.
- W3165514303 hasConcept C2779944601 @default.
- W3165514303 hasConcept C42219234 @default.
- W3165514303 hasConcept C71924100 @default.
- W3165514303 hasConcept C87813604 @default.
- W3165514303 hasConcept C98274493 @default.
- W3165514303 hasConceptScore W3165514303C126322002 @default.
- W3165514303 hasConceptScore W3165514303C141071460 @default.
- W3165514303 hasConceptScore W3165514303C14184104 @default.
- W3165514303 hasConceptScore W3165514303C142724271 @default.
- W3165514303 hasConceptScore W3165514303C168563851 @default.
- W3165514303 hasConceptScore W3165514303C197934379 @default.
- W3165514303 hasConceptScore W3165514303C199343813 @default.
- W3165514303 hasConceptScore W3165514303C202271784 @default.
- W3165514303 hasConceptScore W3165514303C204787440 @default.
- W3165514303 hasConceptScore W3165514303C27081682 @default.
- W3165514303 hasConceptScore W3165514303C2779944601 @default.
- W3165514303 hasConceptScore W3165514303C42219234 @default.
- W3165514303 hasConceptScore W3165514303C71924100 @default.
- W3165514303 hasConceptScore W3165514303C87813604 @default.
- W3165514303 hasConceptScore W3165514303C98274493 @default.
- W3165514303 hasLocation W31655143031 @default.
- W3165514303 hasOpenAccess W3165514303 @default.
- W3165514303 hasPrimaryLocation W31655143031 @default.
- W3165514303 hasRelatedWork W173239477 @default.
- W3165514303 hasRelatedWork W1759618268 @default.
- W3165514303 hasRelatedWork W2025576402 @default.
- W3165514303 hasRelatedWork W2033061713 @default.
- W3165514303 hasRelatedWork W2041321119 @default.
- W3165514303 hasRelatedWork W205366962 @default.
- W3165514303 hasRelatedWork W2067351273 @default.
- W3165514303 hasRelatedWork W2137695415 @default.
- W3165514303 hasRelatedWork W2441769593 @default.
- W3165514303 hasRelatedWork W43017980 @default.
- W3165514303 isParatext "false" @default.
- W3165514303 isRetracted "false" @default.
- W3165514303 magId "3165514303" @default.
- W3165514303 workType "article" @default.