Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165538049> ?p ?o ?g. }
- W3165538049 endingPage "5585" @default.
- W3165538049 startingPage "5585" @default.
- W3165538049 abstract "More and more findings suggest that neurological disorders could have an immunopathological cause. Thus, immune-targeted therapies are increasingly proposed in neurology (even if often controversial), as anakinra, inhibiting IL-1 for febrile inflammatory illnesses, and JAK inhibitors for anti-interferons treatment. Precision medicine in neurology could be fostered by a better understanding of the disease machinery, to develop a rational use of immuno-modulators in clinical trials. In this review, we focus on monogenic disorders with neurological hyper-inflammation/autoimmunity as simplified “models” to correlate immune pathology and targeted treatments. The study of monogenic models yields great advantages for the elucidation of the pathogenic mechanisms that can be reproduced in cellular/animal models, overcoming the limitations of biological samples to study. Moreover, monogenic disorders provide a unique tool to study the mechanisms of neuroinflammatory and autoimmune brain damage, in all their manifestations. The insight of clinical, pathological, and therapeutic aspects of the considered monogenic models can impact knowledge about brain inflammation and can provide useful hints to better understand and cure some neurologic multifactorial disorders." @default.
- W3165538049 created "2021-06-07" @default.
- W3165538049 creator A5018348348 @default.
- W3165538049 creator A5027001739 @default.
- W3165538049 creator A5039828441 @default.
- W3165538049 creator A5056849696 @default.
- W3165538049 creator A5077006699 @default.
- W3165538049 date "2021-05-24" @default.
- W3165538049 modified "2023-09-27" @default.
- W3165538049 title "Vasculitis, Autoimmunity, and Cytokines: How the Immune System Can Harm the Brain" @default.
- W3165538049 cites W1497089859 @default.
- W3165538049 cites W1501451008 @default.
- W3165538049 cites W1514239588 @default.
- W3165538049 cites W1594574415 @default.
- W3165538049 cites W1916121669 @default.
- W3165538049 cites W1974552427 @default.
- W3165538049 cites W1979534455 @default.
- W3165538049 cites W1985383819 @default.
- W3165538049 cites W1993722498 @default.
- W3165538049 cites W1995744610 @default.
- W3165538049 cites W1999610899 @default.
- W3165538049 cites W2010252780 @default.
- W3165538049 cites W2011678998 @default.
- W3165538049 cites W2013183032 @default.
- W3165538049 cites W2015310325 @default.
- W3165538049 cites W2016318369 @default.
- W3165538049 cites W2020173029 @default.
- W3165538049 cites W2025735417 @default.
- W3165538049 cites W2031423498 @default.
- W3165538049 cites W2037468153 @default.
- W3165538049 cites W2041084308 @default.
- W3165538049 cites W2045864910 @default.
- W3165538049 cites W2055110904 @default.
- W3165538049 cites W2057150798 @default.
- W3165538049 cites W2060926084 @default.
- W3165538049 cites W2063963084 @default.
- W3165538049 cites W2070604607 @default.
- W3165538049 cites W2071556127 @default.
- W3165538049 cites W2090920251 @default.
- W3165538049 cites W2099610218 @default.
- W3165538049 cites W2099808663 @default.
- W3165538049 cites W2102260696 @default.
- W3165538049 cites W2104966068 @default.
- W3165538049 cites W2106566281 @default.
- W3165538049 cites W2110632763 @default.
- W3165538049 cites W2110864354 @default.
- W3165538049 cites W2111913995 @default.
- W3165538049 cites W2113757071 @default.
- W3165538049 cites W2114690058 @default.
- W3165538049 cites W2117679109 @default.
- W3165538049 cites W2122822209 @default.
- W3165538049 cites W2130302910 @default.
- W3165538049 cites W2133402546 @default.
- W3165538049 cites W2136935019 @default.
- W3165538049 cites W2138282259 @default.
- W3165538049 cites W2146466204 @default.
- W3165538049 cites W2149374693 @default.
- W3165538049 cites W2151064612 @default.
- W3165538049 cites W2154171253 @default.
- W3165538049 cites W2159659449 @default.
- W3165538049 cites W2164013854 @default.
- W3165538049 cites W2167317609 @default.
- W3165538049 cites W2169933147 @default.
- W3165538049 cites W2171138396 @default.
- W3165538049 cites W2172057670 @default.
- W3165538049 cites W2277976146 @default.
- W3165538049 cites W2284005203 @default.
- W3165538049 cites W2318971911 @default.
- W3165538049 cites W2507602581 @default.
- W3165538049 cites W2508023113 @default.
- W3165538049 cites W2508238341 @default.
- W3165538049 cites W2516960518 @default.
- W3165538049 cites W2521254998 @default.
- W3165538049 cites W2527759663 @default.
- W3165538049 cites W2545425107 @default.
- W3165538049 cites W2551404503 @default.
- W3165538049 cites W2559955759 @default.
- W3165538049 cites W2564819117 @default.
- W3165538049 cites W2581533407 @default.
- W3165538049 cites W2588463485 @default.
- W3165538049 cites W2590588430 @default.
- W3165538049 cites W2595749075 @default.
- W3165538049 cites W2609075224 @default.
- W3165538049 cites W2614667497 @default.
- W3165538049 cites W2621156483 @default.
- W3165538049 cites W2625419804 @default.
- W3165538049 cites W2625709437 @default.
- W3165538049 cites W270322905 @default.
- W3165538049 cites W2748190516 @default.
- W3165538049 cites W2755386504 @default.
- W3165538049 cites W2762266182 @default.
- W3165538049 cites W2793235194 @default.
- W3165538049 cites W2795867865 @default.
- W3165538049 cites W2796372149 @default.
- W3165538049 cites W2796581040 @default.
- W3165538049 cites W2801073031 @default.
- W3165538049 cites W2803368193 @default.
- W3165538049 cites W2810265958 @default.