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- W3165564589 abstract "Human thermoregulatory control is often evaluated through the relationship between thermoeffector output and core or mean body temperature. In addition to providing a general indication of whether a variable of interest alters thermoregulatory control, this relationship is often used to determine how this alteration may occur. This latter interpretation relies upon two parameters of the thermoeffector output-body temperature relationship: the onset threshold and thermosensitivity. Traditionally, changes in the onset threshold and thermosensitivity are interpreted as “central” or “peripheral” modulation of thermoregulatory control, respectively. This mini-review revisits the origins of the thermoeffector output-body temperature relationship and its use to interpret “central” or “peripheral” modulation of thermoregulatory control. Against this background, we discuss the strengths and weaknesses of this approach and highlight that “central” thermoregulatory control reflects the neural control of body temperature whereas “peripheral” thermoregulatory control reflects properties specific to the thermoeffector organs. We highlight studies that employed more direct approaches to investigate the neural control of body temperature and peripheral properties of thermoeffector organs. We conclude by encouraging future investigations interested in studying thermoregulatory control to more directly investigate the component of the thermoeffector loop under investigation. heat; human; skin blood flow; sweat; thermoregulatory" @default.
- W3165564589 created "2021-06-07" @default.
- W3165564589 creator A5007003301 @default.
- W3165564589 creator A5023389206 @default.
- W3165564589 creator A5051236275 @default.
- W3165564589 date "2021-08-01" @default.
- W3165564589 modified "2023-10-01" @default.
- W3165564589 title "Revisiting the evaluation of central versus peripheral thermoregulatory control in humans" @default.
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- W3165564589 doi "https://doi.org/10.1152/ajpregu.00321.2020" @default.
- W3165564589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34075801" @default.
- W3165564589 hasPublicationYear "2021" @default.
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