Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165631944> ?p ?o ?g. }
- W3165631944 endingPage "2262" @default.
- W3165631944 startingPage "2262" @default.
- W3165631944 abstract "Despite improvements in understanding the pathogenic mechanisms of primary glomerular diseases, therapy still remains nonspecific. We sought to identify novel therapies targeting kidney-intrinsic injury of distinct primary glomerulonephritides through computational systems biology approaches. We defined the unique transcriptional landscape within kidneys from patients with focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), immunoglobulin A nephropathy (IgAN), membranous nephropathy (MN) and thin basement membrane nephropathy (TBMN). Differentially expressed genes were functionally annotated with enrichment analysis, and distinct biological processes and pathways implicated in each primary glomerular disease were uncovered. Finally, we identified novel drugs and small-molecule compounds that may reverse each glomerulonephritis phenotype, suggesting they should be further tested as precise therapy in primary glomerular diseases." @default.
- W3165631944 created "2021-06-07" @default.
- W3165631944 creator A5003799358 @default.
- W3165631944 creator A5003996745 @default.
- W3165631944 creator A5015231732 @default.
- W3165631944 creator A5057945564 @default.
- W3165631944 date "2021-05-24" @default.
- W3165631944 modified "2023-09-27" @default.
- W3165631944 title "Gene Expression as a Guide to the Development of Novel Therapies in Primary Glomerular Diseases" @default.
- W3165631944 cites W1560020441 @default.
- W3165631944 cites W1986167294 @default.
- W3165631944 cites W2000762006 @default.
- W3165631944 cites W2001569772 @default.
- W3165631944 cites W2009132304 @default.
- W3165631944 cites W2011460189 @default.
- W3165631944 cites W2014437621 @default.
- W3165631944 cites W2018844943 @default.
- W3165631944 cites W2028478459 @default.
- W3165631944 cites W2030084418 @default.
- W3165631944 cites W2069034590 @default.
- W3165631944 cites W2083760961 @default.
- W3165631944 cites W2092521106 @default.
- W3165631944 cites W2094936663 @default.
- W3165631944 cites W2095708527 @default.
- W3165631944 cites W2100004314 @default.
- W3165631944 cites W2104317136 @default.
- W3165631944 cites W2106321700 @default.
- W3165631944 cites W2110405088 @default.
- W3165631944 cites W2121604817 @default.
- W3165631944 cites W2140733306 @default.
- W3165631944 cites W2142895007 @default.
- W3165631944 cites W2143784594 @default.
- W3165631944 cites W2144980016 @default.
- W3165631944 cites W2151098851 @default.
- W3165631944 cites W2163573273 @default.
- W3165631944 cites W2170146596 @default.
- W3165631944 cites W2400851845 @default.
- W3165631944 cites W2489003193 @default.
- W3165631944 cites W2534322402 @default.
- W3165631944 cites W2560560224 @default.
- W3165631944 cites W2593771998 @default.
- W3165631944 cites W2761936011 @default.
- W3165631944 cites W2768977980 @default.
- W3165631944 cites W2783430372 @default.
- W3165631944 cites W2791340464 @default.
- W3165631944 cites W2794313083 @default.
- W3165631944 cites W2905380903 @default.
- W3165631944 cites W2910019464 @default.
- W3165631944 cites W2911907767 @default.
- W3165631944 cites W2915966197 @default.
- W3165631944 cites W2944545583 @default.
- W3165631944 cites W2981149705 @default.
- W3165631944 cites W3037749322 @default.
- W3165631944 cites W3080404555 @default.
- W3165631944 cites W3092889874 @default.
- W3165631944 cites W3097796593 @default.
- W3165631944 cites W3126993375 @default.
- W3165631944 cites W4211021420 @default.
- W3165631944 cites W4211190065 @default.
- W3165631944 doi "https://doi.org/10.3390/jcm10112262" @default.
- W3165631944 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8197155" @default.
- W3165631944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34073694" @default.
- W3165631944 hasPublicationYear "2021" @default.
- W3165631944 type Work @default.
- W3165631944 sameAs 3165631944 @default.
- W3165631944 citedByCount "0" @default.
- W3165631944 crossrefType "journal-article" @default.
- W3165631944 hasAuthorship W3165631944A5003799358 @default.
- W3165631944 hasAuthorship W3165631944A5003996745 @default.
- W3165631944 hasAuthorship W3165631944A5015231732 @default.
- W3165631944 hasAuthorship W3165631944A5057945564 @default.
- W3165631944 hasBestOaLocation W31656319441 @default.
- W3165631944 hasConcept C104317684 @default.
- W3165631944 hasConcept C126322002 @default.
- W3165631944 hasConcept C127716648 @default.
- W3165631944 hasConcept C134018914 @default.
- W3165631944 hasConcept C142724271 @default.
- W3165631944 hasConcept C203014093 @default.
- W3165631944 hasConcept C2775946357 @default.
- W3165631944 hasConcept C2776115139 @default.
- W3165631944 hasConcept C2777390665 @default.
- W3165631944 hasConcept C2777747828 @default.
- W3165631944 hasConcept C2778415529 @default.
- W3165631944 hasConcept C2778653478 @default.
- W3165631944 hasConcept C2779134260 @default.
- W3165631944 hasConcept C2779561371 @default.
- W3165631944 hasConcept C2780091579 @default.
- W3165631944 hasConcept C2780368995 @default.
- W3165631944 hasConcept C2781184683 @default.
- W3165631944 hasConcept C54355233 @default.
- W3165631944 hasConcept C555293320 @default.
- W3165631944 hasConcept C60644358 @default.
- W3165631944 hasConcept C71924100 @default.
- W3165631944 hasConcept C86803240 @default.
- W3165631944 hasConceptScore W3165631944C104317684 @default.
- W3165631944 hasConceptScore W3165631944C126322002 @default.
- W3165631944 hasConceptScore W3165631944C127716648 @default.
- W3165631944 hasConceptScore W3165631944C134018914 @default.