Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165640442> ?p ?o ?g. }
- W3165640442 abstract "Histone acetylation is a key histone post-translational modification that shapes chromatin structure, dynamics, and function. Bromodomain (BRD) proteins, the readers of acetyl-lysines, are located in the center of the histone acetylation-signaling network. How they regulate DNA repair and genome stability remains poorly understood. Here, a conserved function of the yeast Bromodomain Factor 1 (Bdf1) and its human counterpart TAF1 is reported in promoting DNA double-stranded break repair by homologous recombination (HR). Depletion of either yeast BDF1 or human TAF1, or disruption of their BRDs impairs DNA end resection, Replication Protein A (RPA) and Rad51 loading, and HR repair, causing genome instability and hypersensitivity to DNA damage. Mechanistically, it is shown that Bdf1 preferentially binds the DNA damage-induced histone H4 acetylation (H4Ac) via the BRD motifs, leading to its chromatin recruitment. Meanwhile, Bdf1 physically interacts with RPA, and this interaction facilitates RPA loading in the chromatin context and the subsequent HR repair. Similarly, TAF1 also interacts with H4Ac or RPA. Thus, Bdf1 and TAF1 appear to share a conserved mechanism in linking the HR repair to chromatin acetylation in preserving genome integrity." @default.
- W3165640442 created "2021-06-07" @default.
- W3165640442 creator A5000693667 @default.
- W3165640442 creator A5008349766 @default.
- W3165640442 creator A5014460750 @default.
- W3165640442 creator A5016522900 @default.
- W3165640442 creator A5029410465 @default.
- W3165640442 creator A5033071749 @default.
- W3165640442 creator A5033764486 @default.
- W3165640442 creator A5036514101 @default.
- W3165640442 creator A5053780153 @default.
- W3165640442 creator A5062962272 @default.
- W3165640442 creator A5064217591 @default.
- W3165640442 creator A5064735218 @default.
- W3165640442 creator A5078936866 @default.
- W3165640442 creator A5079005962 @default.
- W3165640442 date "2021-05-30" @default.
- W3165640442 modified "2023-10-16" @default.
- W3165640442 title "Yeast Bromodomain Factor 1 and Its Human Homolog TAF1 Play Conserved Roles in Promoting Homologous Recombination" @default.
- W3165640442 cites W1516663492 @default.
- W3165640442 cites W1525575010 @default.
- W3165640442 cites W1625510017 @default.
- W3165640442 cites W1954246782 @default.
- W3165640442 cites W1964549900 @default.
- W3165640442 cites W1965593950 @default.
- W3165640442 cites W1966792552 @default.
- W3165640442 cites W1967667819 @default.
- W3165640442 cites W1984373702 @default.
- W3165640442 cites W1989723272 @default.
- W3165640442 cites W1990103859 @default.
- W3165640442 cites W1993026474 @default.
- W3165640442 cites W1997974935 @default.
- W3165640442 cites W2001680897 @default.
- W3165640442 cites W2009167909 @default.
- W3165640442 cites W2012635057 @default.
- W3165640442 cites W2017261393 @default.
- W3165640442 cites W2017275209 @default.
- W3165640442 cites W2021029128 @default.
- W3165640442 cites W2022439334 @default.
- W3165640442 cites W2033517491 @default.
- W3165640442 cites W2034949406 @default.
- W3165640442 cites W2036685117 @default.
- W3165640442 cites W2039564969 @default.
- W3165640442 cites W2040681936 @default.
- W3165640442 cites W2043895957 @default.
- W3165640442 cites W2044288748 @default.
- W3165640442 cites W2045090937 @default.
- W3165640442 cites W2050357231 @default.
- W3165640442 cites W2060745312 @default.
- W3165640442 cites W2061925865 @default.
- W3165640442 cites W2069949084 @default.
- W3165640442 cites W2073631639 @default.
- W3165640442 cites W2081099987 @default.
- W3165640442 cites W2085299836 @default.
- W3165640442 cites W2088853419 @default.
- W3165640442 cites W2090438862 @default.
- W3165640442 cites W2094020226 @default.
- W3165640442 cites W2101465904 @default.
- W3165640442 cites W2104003823 @default.
- W3165640442 cites W2105989207 @default.
- W3165640442 cites W2108958484 @default.
- W3165640442 cites W2114720084 @default.
- W3165640442 cites W2123647733 @default.
- W3165640442 cites W2125666185 @default.
- W3165640442 cites W2128542570 @default.
- W3165640442 cites W2145506563 @default.
- W3165640442 cites W2154032810 @default.
- W3165640442 cites W2158602985 @default.
- W3165640442 cites W2161204327 @default.
- W3165640442 cites W2161329609 @default.
- W3165640442 cites W2161880719 @default.
- W3165640442 cites W2165364443 @default.
- W3165640442 cites W2169001246 @default.
- W3165640442 cites W2171775098 @default.
- W3165640442 cites W2173561323 @default.
- W3165640442 cites W2312770177 @default.
- W3165640442 cites W2413931725 @default.
- W3165640442 cites W2515024464 @default.
- W3165640442 cites W2530612380 @default.
- W3165640442 cites W2558818939 @default.
- W3165640442 cites W2567864937 @default.
- W3165640442 cites W2587980633 @default.
- W3165640442 cites W2612088293 @default.
- W3165640442 cites W2737847131 @default.
- W3165640442 cites W2746090771 @default.
- W3165640442 cites W2787958170 @default.
- W3165640442 cites W2886597733 @default.
- W3165640442 cites W2890203184 @default.
- W3165640442 cites W2892569542 @default.
- W3165640442 cites W2896605468 @default.
- W3165640442 cites W2949150764 @default.
- W3165640442 cites W2950118063 @default.
- W3165640442 cites W2982372904 @default.
- W3165640442 cites W2991176781 @default.
- W3165640442 cites W3033655624 @default.
- W3165640442 doi "https://doi.org/10.1002/advs.202100753" @default.
- W3165640442 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8336524" @default.
- W3165640442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34056863" @default.
- W3165640442 hasPublicationYear "2021" @default.
- W3165640442 type Work @default.