Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165652007> ?p ?o ?g. }
- W3165652007 abstract "Currently, the management of acute and chronic pain in clinical practice remains unsatisfactory due to the existence of limited effective treatments, and novel therapeutic strategies for pathological pain are urgently needed. In the past few decades, the role of serum and glucocorticoid-inducible kinase 1 (SGK1) in the development of pain and diurnal rhythms has been implicated in numerous studies. The expression levels of SGK1 mRNA and protein were found to be elevated in the spinal cord and brain in various pathological pain models. Blocking SGK1 significantly attenuated pain-like responses and the development of pathological pain. These studies provide strong evidence that SGK1 plays a role in the development of various types of pathological pain and that targeting SGK1 may be a novel therapeutic strategy for pain management. In this review article, we provide evidence from animal models for the potential role of SGK1 in the regulation of pathological pain caused by inflammation, nerve injury, psychiatric disorders, and chronic opioid exposure." @default.
- W3165652007 created "2021-06-07" @default.
- W3165652007 creator A5004274878 @default.
- W3165652007 creator A5046829016 @default.
- W3165652007 creator A5074243377 @default.
- W3165652007 creator A5077611123 @default.
- W3165652007 creator A5088104887 @default.
- W3165652007 date "2021-05-20" @default.
- W3165652007 modified "2023-10-14" @default.
- W3165652007 title "Emerging Role of Serum Glucocorticoid-Regulated Kinase 1 in Pathological Pain" @default.
- W3165652007 cites W1527764000 @default.
- W3165652007 cites W1538723583 @default.
- W3165652007 cites W1676497584 @default.
- W3165652007 cites W1965511761 @default.
- W3165652007 cites W1965887845 @default.
- W3165652007 cites W1967424759 @default.
- W3165652007 cites W1969213411 @default.
- W3165652007 cites W1970081688 @default.
- W3165652007 cites W1977518774 @default.
- W3165652007 cites W1978626885 @default.
- W3165652007 cites W1980433774 @default.
- W3165652007 cites W1988405987 @default.
- W3165652007 cites W1990970865 @default.
- W3165652007 cites W1993835711 @default.
- W3165652007 cites W1996525778 @default.
- W3165652007 cites W1996676553 @default.
- W3165652007 cites W1997986332 @default.
- W3165652007 cites W1998185442 @default.
- W3165652007 cites W1999916995 @default.
- W3165652007 cites W2002260497 @default.
- W3165652007 cites W2010637356 @default.
- W3165652007 cites W2015721095 @default.
- W3165652007 cites W2018984161 @default.
- W3165652007 cites W2024469079 @default.
- W3165652007 cites W2028053979 @default.
- W3165652007 cites W2031762224 @default.
- W3165652007 cites W2035752371 @default.
- W3165652007 cites W2037013399 @default.
- W3165652007 cites W2038457087 @default.
- W3165652007 cites W2038487059 @default.
- W3165652007 cites W2049234448 @default.
- W3165652007 cites W2049671233 @default.
- W3165652007 cites W2049972797 @default.
- W3165652007 cites W2050247484 @default.
- W3165652007 cites W2050370133 @default.
- W3165652007 cites W2058917347 @default.
- W3165652007 cites W2059388291 @default.
- W3165652007 cites W2069270633 @default.
- W3165652007 cites W2069319080 @default.
- W3165652007 cites W2070249204 @default.
- W3165652007 cites W2071899220 @default.
- W3165652007 cites W2075971181 @default.
- W3165652007 cites W2079413441 @default.
- W3165652007 cites W2084255719 @default.
- W3165652007 cites W2084724759 @default.
- W3165652007 cites W2103289098 @default.
- W3165652007 cites W2103812437 @default.
- W3165652007 cites W2111123535 @default.
- W3165652007 cites W2112752919 @default.
- W3165652007 cites W2114992599 @default.
- W3165652007 cites W2119225361 @default.
- W3165652007 cites W2121339490 @default.
- W3165652007 cites W2125056253 @default.
- W3165652007 cites W2126059053 @default.
- W3165652007 cites W2130141996 @default.
- W3165652007 cites W2139654366 @default.
- W3165652007 cites W2151595908 @default.
- W3165652007 cites W2151752218 @default.
- W3165652007 cites W2154911070 @default.
- W3165652007 cites W2155218859 @default.
- W3165652007 cites W2165106034 @default.
- W3165652007 cites W2165291356 @default.
- W3165652007 cites W2167816721 @default.
- W3165652007 cites W2170493982 @default.
- W3165652007 cites W2193056702 @default.
- W3165652007 cites W2317897804 @default.
- W3165652007 cites W2396579854 @default.
- W3165652007 cites W2403108842 @default.
- W3165652007 cites W2474248982 @default.
- W3165652007 cites W2509659709 @default.
- W3165652007 cites W2511688551 @default.
- W3165652007 cites W2531473147 @default.
- W3165652007 cites W2559679600 @default.
- W3165652007 cites W2602990635 @default.
- W3165652007 cites W2764250492 @default.
- W3165652007 cites W2885513323 @default.
- W3165652007 cites W2905788968 @default.
- W3165652007 cites W2908632937 @default.
- W3165652007 cites W2915212160 @default.
- W3165652007 cites W2952513829 @default.
- W3165652007 cites W2961737246 @default.
- W3165652007 cites W3093211921 @default.
- W3165652007 cites W3120689928 @default.
- W3165652007 cites W4253861185 @default.
- W3165652007 doi "https://doi.org/10.3389/fnmol.2021.683527" @default.
- W3165652007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8177009" @default.
- W3165652007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34093127" @default.
- W3165652007 hasPublicationYear "2021" @default.
- W3165652007 type Work @default.
- W3165652007 sameAs 3165652007 @default.