FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165695862> ?p ?o ?g. }

• W3165695862 endingPage "112816" @default.
• W3165695862 startingPage "112816" @default.
• W3165695862 abstract "Five undescribed sterol derivatives, (22E,24R)-7α-methoxy-5α,6α-epoxyergosta-8(14),22-diene-3β,15β-diol, (22E,24R)-5α,6α-epoxyergosta-8(14),22-diene-3β,7β,15α-triol, (22E,24R)-3β,5α-dihydroxy-14β,15β-epoxyergosta-7,22-diene-6-one, (22E,24R)-6α-methoxy-7α,15β-dihydroxyergosta-4,8(14),22-triene-3-one, and (25S)-ergosta-7,24(28)-diene-3β,4α,6α,26-tetraol were isolated from the extract of Talaromyces stipitatus, along with eight known congeners. This is the first example of a class of ergosterols isolated from T. stipitatus. Their structures with absolute configurations were elucidated based on NMR spectroscopic data, ECD calculations, and X-ray crystallographic analyses. All these compounds were tested for their effects on three hepatoma cell lines including Hep3B, HepG2, and Huh-7. Moreover, (22E,24R)-5α,6α-epoxyergosta-8(14),22-diene-3β,7β,15α-triol and (22E,24R)-9α,15α-dihydroxyergosta-4,6,8(14),22-tetraen-3-one were further evaluated for their impacts on cell cycle progression and apoptosis due to their pronounced cytotoxicity, to uncover their underlying mechanisms. Our results suggested that their antiproliferative activities were mainly mediated by inducing cell apoptosis." @default.
• W3165695862 created "2021-06-07" @default.
• W3165695862 creator A5008191957 @default.
• W3165695862 creator A5013409727 @default.
• W3165695862 creator A5014954540 @default.
• W3165695862 creator A5016622592 @default.
• W3165695862 creator A5023088239 @default.
• W3165695862 creator A5043180507 @default.
• W3165695862 creator A5048279362 @default.
• W3165695862 creator A5055654386 @default.
• W3165695862 creator A5056388044 @default.
• W3165695862 creator A5058531504 @default.
• W3165695862 creator A5060237979 @default.
• W3165695862 creator A5075080019 @default.
• W3165695862 creator A5088945986 @default.
• W3165695862 date "2021-09-01" @default.
• W3165695862 modified "2023-09-30" @default.
• W3165695862 title "Five undescribed steroids from Talaromyces stipitatus and their cytotoxic activities against hepatoma cell lines" @default.
• W3165695862 cites W1969891492 @default.
• W3165695862 cites W2002239007 @default.
• W3165695862 cites W2007599210 @default.
• W3165695862 cites W2008923801 @default.
• W3165695862 cites W2046212534 @default.
• W3165695862 cites W2081694958 @default.
• W3165695862 cites W2090676280 @default.
• W3165695862 cites W2094187347 @default.
• W3165695862 cites W2270475144 @default.
• W3165695862 cites W2326445536 @default.
• W3165695862 cites W2565059543 @default.
• W3165695862 cites W2582042306 @default.
• W3165695862 cites W2601148710 @default.
• W3165695862 cites W2603167836 @default.
• W3165695862 cites W2615665611 @default.
• W3165695862 cites W2733705455 @default.
• W3165695862 cites W2736952087 @default.
• W3165695862 cites W2789400354 @default.
• W3165695862 cites W2799944448 @default.
• W3165695862 cites W2941961624 @default.
• W3165695862 cites W2947223758 @default.
• W3165695862 cites W2971377411 @default.
• W3165695862 cites W2998581484 @default.
• W3165695862 cites W3009322832 @default.
• W3165695862 cites W3091698275 @default.
• W3165695862 doi "https://doi.org/10.1016/j.phytochem.2021.112816" @default.
• W3165695862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34087503" @default.
• W3165695862 hasPublicationYear "2021" @default.
• W3165695862 type Work @default.
• W3165695862 sameAs 3165695862 @default.
• W3165695862 citedByCount "5" @default.
• W3165695862 countsByYear W31656958622022 @default.
• W3165695862 countsByYear W31656958622023 @default.
• W3165695862 crossrefType "journal-article" @default.
• W3165695862 hasAuthorship W3165695862A5008191957 @default.
• W3165695862 hasAuthorship W3165695862A5013409727 @default.
• W3165695862 hasAuthorship W3165695862A5014954540 @default.
• W3165695862 hasAuthorship W3165695862A5016622592 @default.
• W3165695862 hasAuthorship W3165695862A5023088239 @default.
• W3165695862 hasAuthorship W3165695862A5043180507 @default.
• W3165695862 hasAuthorship W3165695862A5048279362 @default.
• W3165695862 hasAuthorship W3165695862A5055654386 @default.
• W3165695862 hasAuthorship W3165695862A5056388044 @default.
• W3165695862 hasAuthorship W3165695862A5058531504 @default.
• W3165695862 hasAuthorship W3165695862A5060237979 @default.
• W3165695862 hasAuthorship W3165695862A5075080019 @default.
• W3165695862 hasAuthorship W3165695862A5088945986 @default.
• W3165695862 hasConcept C109316439 @default.
• W3165695862 hasConcept C154317977 @default.
• W3165695862 hasConcept C176933379 @default.
• W3165695862 hasConcept C178790620 @default.
• W3165695862 hasConcept C185592680 @default.
• W3165695862 hasConcept C190283241 @default.
• W3165695862 hasConcept C19549132 @default.
• W3165695862 hasConcept C202751555 @default.
• W3165695862 hasConcept C2778163477 @default.
• W3165695862 hasConcept C2778718757 @default.
• W3165695862 hasConcept C2778733088 @default.
• W3165695862 hasConcept C2779515768 @default.
• W3165695862 hasConcept C2781306241 @default.
• W3165695862 hasConcept C54355233 @default.
• W3165695862 hasConcept C55493867 @default.
• W3165695862 hasConcept C71240020 @default.
• W3165695862 hasConcept C81885089 @default.
• W3165695862 hasConcept C86803240 @default.
• W3165695862 hasConceptScore W3165695862C109316439 @default.
• W3165695862 hasConceptScore W3165695862C154317977 @default.
• W3165695862 hasConceptScore W3165695862C176933379 @default.
• W3165695862 hasConceptScore W3165695862C178790620 @default.
• W3165695862 hasConceptScore W3165695862C185592680 @default.
• W3165695862 hasConceptScore W3165695862C190283241 @default.
• W3165695862 hasConceptScore W3165695862C19549132 @default.
• W3165695862 hasConceptScore W3165695862C202751555 @default.
• W3165695862 hasConceptScore W3165695862C2778163477 @default.
• W3165695862 hasConceptScore W3165695862C2778718757 @default.
• W3165695862 hasConceptScore W3165695862C2778733088 @default.
• W3165695862 hasConceptScore W3165695862C2779515768 @default.
• W3165695862 hasConceptScore W3165695862C2781306241 @default.
• W3165695862 hasConceptScore W3165695862C54355233 @default.
• W3165695862 hasConceptScore W3165695862C55493867 @default.

• next