FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165747523> ?p ?o ?g. }

• W3165747523 abstract "To explore how pathogenic mutations of the multidomain leucine-rich repeat kinase 2 (LRRK2) hijack its finely tuned activation process and drive Parkinson's disease (PD), we used a multitiered approach. Most mutations mimic Rab-mediated activation by unleashing kinase activity, and many, like the kinase inhibitor MLi-2, trap LRRK2 onto microtubules. Here we mimic activation by simply deleting the inhibitory N-terminal domains and then characterize conformational changes induced by MLi-2 and PD mutations. After confirming that LRRK2RCKW retains full kinase activity, we used hydrogen-deuterium exchange mass spectrometry to capture breathing dynamics in the presence and absence of MLi-2. Solvent-accessible regions throughout the entire protein are reduced by MLi-2 binding. With molecular dynamics simulations, we created a dynamic portrait of LRRK2RCKW and demonstrate the consequences of kinase domain mutations. Although all domains contribute to regulating kinase activity, the kinase domain, driven by the DYGψ motif, is the allosteric hub that drives LRRK2 regulation." @default.
• W3165747523 created "2021-06-07" @default.
• W3165747523 creator A5006568947 @default.
• W3165747523 creator A5013336817 @default.
• W3165747523 creator A5016683019 @default.
• W3165747523 creator A5038777732 @default.
• W3165747523 creator A5042127936 @default.
• W3165747523 creator A5043793429 @default.
• W3165747523 creator A5045962448 @default.
• W3165747523 creator A5046102875 @default.
• W3165747523 creator A5049002810 @default.
• W3165747523 creator A5055797080 @default.
• W3165747523 creator A5073606848 @default.
• W3165747523 creator A5090504058 @default.
• W3165747523 date "2021-06-04" @default.
• W3165747523 modified "2023-10-14" @default.
• W3165747523 title "Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2" @default.
• W3165747523 cites W1933326574 @default.
• W3165747523 cites W1967900265 @default.
• W3165747523 cites W1969939692 @default.
• W3165747523 cites W1977391806 @default.
• W3165747523 cites W2004536040 @default.
• W3165747523 cites W2007537308 @default.
• W3165747523 cites W2011658408 @default.
• W3165747523 cites W2032206743 @default.
• W3165747523 cites W2033185023 @default.
• W3165747523 cites W2051165598 @default.
• W3165747523 cites W2055560959 @default.
• W3165747523 cites W2074383422 @default.
• W3165747523 cites W2075995070 @default.
• W3165747523 cites W2099111846 @default.
• W3165747523 cites W2120262230 @default.
• W3165747523 cites W2124662474 @default.
• W3165747523 cites W2124681346 @default.
• W3165747523 cites W2126329788 @default.
• W3165747523 cites W2143442755 @default.
• W3165747523 cites W2166542272 @default.
• W3165747523 cites W2174927436 @default.
• W3165747523 cites W2319002174 @default.
• W3165747523 cites W2338776562 @default.
• W3165747523 cites W2418602678 @default.
• W3165747523 cites W2466125837 @default.
• W3165747523 cites W2593373447 @default.
• W3165747523 cites W2609407882 @default.
• W3165747523 cites W2761421730 @default.
• W3165747523 cites W2763029597 @default.
• W3165747523 cites W2771688344 @default.
• W3165747523 cites W2791662743 @default.
• W3165747523 cites W2899593101 @default.
• W3165747523 cites W2904364223 @default.
• W3165747523 cites W2944220740 @default.
• W3165747523 cites W2960012086 @default.
• W3165747523 cites W2976101375 @default.
• W3165747523 cites W2978479061 @default.
• W3165747523 cites W2992240436 @default.
• W3165747523 cites W3002983131 @default.
• W3165747523 cites W3006945870 @default.
• W3165747523 cites W3009156668 @default.
• W3165747523 cites W3009357997 @default.
• W3165747523 cites W3015224068 @default.
• W3165747523 cites W3048909661 @default.
• W3165747523 cites W3068292362 @default.
• W3165747523 cites W4243495780 @default.
• W3165747523 doi "https://doi.org/10.1073/pnas.2100844118" @default.
• W3165747523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8201809" @default.
• W3165747523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34088839" @default.
• W3165747523 hasPublicationYear "2021" @default.
• W3165747523 type Work @default.
• W3165747523 sameAs 3165747523 @default.
• W3165747523 citedByCount "29" @default.
• W3165747523 countsByYear W31657475232021 @default.
• W3165747523 countsByYear W31657475232022 @default.
• W3165747523 countsByYear W31657475232023 @default.
• W3165747523 crossrefType "journal-article" @default.
• W3165747523 hasAuthorship W3165747523A5006568947 @default.
• W3165747523 hasAuthorship W3165747523A5013336817 @default.
• W3165747523 hasAuthorship W3165747523A5016683019 @default.
• W3165747523 hasAuthorship W3165747523A5038777732 @default.
• W3165747523 hasAuthorship W3165747523A5042127936 @default.
• W3165747523 hasAuthorship W3165747523A5043793429 @default.
• W3165747523 hasAuthorship W3165747523A5045962448 @default.
• W3165747523 hasAuthorship W3165747523A5046102875 @default.
• W3165747523 hasAuthorship W3165747523A5049002810 @default.
• W3165747523 hasAuthorship W3165747523A5055797080 @default.
• W3165747523 hasAuthorship W3165747523A5073606848 @default.
• W3165747523 hasAuthorship W3165747523A5090504058 @default.
• W3165747523 hasBestOaLocation W31657475231 @default.
• W3165747523 hasConcept C104317684 @default.
• W3165747523 hasConcept C12554922 @default.
• W3165747523 hasConcept C143065580 @default.
• W3165747523 hasConcept C166342909 @default.
• W3165747523 hasConcept C181199279 @default.
• W3165747523 hasConcept C184235292 @default.
• W3165747523 hasConcept C185592680 @default.
• W3165747523 hasConcept C2780427247 @default.
• W3165747523 hasConcept C32619005 @default.
• W3165747523 hasConcept C501734568 @default.
• W3165747523 hasConcept C55493867 @default.
• W3165747523 hasConcept C59143045 @default.
• W3165747523 hasConcept C82495950 @default.

• next