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- W3165811727 abstract "Mammalian medial and lateral hippocampal networks preferentially process spatial- and object-related information, respectively. However, the mechanisms underlying the assembly of such parallel networks during development remain largely unknown. Our study shows that, in mice, complementary expression of cell surface molecules teneurin-3 (Ten3) and latrophilin-2 (Lphn2) in the medial and lateral hippocampal networks, respectively, guides the precise assembly of CA1-to-subiculum connections in both networks. In the medial network, Ten3-expressing (Ten3+) CA1 axons are repelled by target-derived Lphn2, revealing that Lphn2- and Ten3-mediated heterophilic repulsion and Ten3-mediated homophilic attraction cooperate to control precise target selection of CA1 axons. In the lateral network, Lphn2-expressing (Lphn2+) CA1 axons are confined to Lphn2+ targets via repulsion from Ten3+ targets. Our findings demonstrate that assembly of parallel hippocampal networks follows a Ten3→Ten3, Lphn2→Lphn2 rule instructed by reciprocal repulsions." @default.
- W3165811727 created "2021-06-07" @default.
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- W3165811727 date "2021-06-04" @default.
- W3165811727 modified "2023-10-01" @default.
- W3165811727 title "Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks" @default.
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- W3165811727 doi "https://doi.org/10.1126/science.abg1774" @default.
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