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- W3165816141 abstract "Glaucoma is the leading cause of irreversible blindness worldwide. As a chronic progressive disorder, it often requires long-term management of drugs on patients’ own initiative. However, shortages are displayed by the current antiglaucoma drugs in the market such as low bioavailability due to multiple biological barriers of human eyes and therefore the demands for frequent dosage regimen per day, which could lead to concomitant side effects and eventually deficiency in patient adherence. Recently, nanomedicines have been posing optimized alternatives over conventional ophthalmic formulations through improved barrier permeability, sustained drug release, tissue targeting, and lowered systemic absorption of instilled medications. These merits in the meantime enable the active ingredients an effective way to reach the ideal concentration at places where damaged nerves locate, offering a promising platform for neuroprotective treatments of the disease. Here, nanomedicines and nanomedicine-based novel strategies for the pharmacotherapy of glaucoma were reviewed, including liposomes, niosomes, nanoparticles, and dendrimers. The article intended to offer a comprehensive grasp of frontier progresses as well as hotspots and issues that appeared in this field, which may enable a practical flourish in the future." @default.
- W3165816141 created "2021-06-07" @default.
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- W3165816141 date "2020-01-01" @default.
- W3165816141 modified "2023-10-16" @default.
- W3165816141 title "Nanomedicines for the Treatment of Glaucoma: Current Status and Future Perspectives" @default.
- W3165816141 doi "https://doi.org/10.2139/ssrn.3683604" @default.
- W3165816141 hasPublicationYear "2020" @default.
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