FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165839861> ?p ?o ?g. }

• W3165839861 abstract "Abstract Background Tumor-associated macrophages (TAMs), inflammatory cells in tumor microenvironment, are crucial for the tumor occurrence and progression which in turn increase the expression of soluble CD163 (sCD163). Nevertheless, not much has been established regarding sCD163 and its connection to HCC diagnosis and prognosis. This study was conducted to evaluate the diagnostic and prognostic role of sCD163 in patients with HCC on top of HCV-related liver cirrhosis. Forty adult patients with HCV-related liver cirrhosis and HCC (HCC group) were randomly selected and subjected to locoregional therapies, either transarterial chemoembolization (TACE) or radiofrequency ablation (RFA). Four patients were excluded because of portal vein invasion. Another group of 20 patients with liver cirrhosis only served as controls (LC group). Routine laboratory studies and abdominal ultrasound were done for all. Alpha-fetoprotein (AFP) and sCD163 were measured twice, at baseline and 1-month post-intervention, using a commercially available enzyme-linked immunosorbent assay kit. Results At baseline, sCD163 showed an insignificant higher value in HCC group ( p > 0.05). The best cutoff value for sCD163 and AFP was 6.2 mg/L and 195 ng/mL, respectively. AFP had a larger area under the curve (0.88 vs. 0.767). An overall significant decline was seen in sCD163 after treatment (6.5±1.5 to 3.1±2.5 mg/L; p < 0.001), while AFP showed an insignificant decrease ( p > 0.05). Also, sCD163 decreased significantly in the eradicated cases (6.1±1.4 mg/L before intervention vs. 2.3±1.4 mg/L after intervention, p < 0.01), while there was a significant increase in the recurrent cases (8.4±0.4 mg/L before intervention vs. 10.3±1.6 after intervention; p < 0.05). Moreover, sCD163 showed a significant difference in its pre-intervention and post-intervention values between recurrent and eradicated HCC cases ( p < 0.01). Conclusions It is concluded that sCD163 has a minor role as a diagnostic marker for HCC, yet it could be used as a good prognostic marker in predicting the tumor response to locoregional therapies." @default.
• W3165839861 created "2021-06-07" @default.
• W3165839861 creator A5015381800 @default.
• W3165839861 creator A5024292276 @default.
• W3165839861 creator A5026102133 @default.
• W3165839861 creator A5034559392 @default.
• W3165839861 creator A5036815852 @default.
• W3165839861 creator A5058026179 @default.
• W3165839861 date "2021-03-27" @default.
• W3165839861 modified "2023-10-12" @default.
• W3165839861 title "Diagnostic and prognostic value of serum soluble CD163 in cirrhotic patients with hepatitis C virus-related hepatocellular carcinoma before and after locoregional therapy" @default.
• W3165839861 cites W110869217 @default.
• W3165839861 cites W1965691731 @default.
• W3165839861 cites W1970673999 @default.
• W3165839861 cites W1971189741 @default.
• W3165839861 cites W1980603418 @default.
• W3165839861 cites W1981315061 @default.
• W3165839861 cites W1982543840 @default.
• W3165839861 cites W2006682256 @default.
• W3165839861 cites W2032066378 @default.
• W3165839861 cites W2063768001 @default.
• W3165839861 cites W2086121620 @default.
• W3165839861 cites W2095866442 @default.
• W3165839861 cites W2118257856 @default.
• W3165839861 cites W2142478451 @default.
• W3165839861 cites W2163403599 @default.
• W3165839861 cites W2205830781 @default.
• W3165839861 cites W2283284501 @default.
• W3165839861 cites W2398235143 @default.
• W3165839861 cites W2406438510 @default.
• W3165839861 cites W2755693293 @default.
• W3165839861 cites W2761031851 @default.
• W3165839861 cites W2783948736 @default.
• W3165839861 cites W2786099441 @default.
• W3165839861 cites W2888259312 @default.
• W3165839861 cites W2888286934 @default.
• W3165839861 cites W2938945681 @default.
• W3165839861 cites W2969802526 @default.
• W3165839861 cites W2996592792 @default.
• W3165839861 cites W3026575543 @default.
• W3165839861 cites W3093709938 @default.
• W3165839861 cites W3094871321 @default.
• W3165839861 cites W2047002506 @default.
• W3165839861 doi "https://doi.org/10.1186/s43066-021-00090-y" @default.
• W3165839861 hasPublicationYear "2021" @default.
• W3165839861 type Work @default.
• W3165839861 sameAs 3165839861 @default.
• W3165839861 citedByCount "2" @default.
• W3165839861 countsByYear W31658398612021 @default.
• W3165839861 countsByYear W31658398612023 @default.
• W3165839861 crossrefType "journal-article" @default.
• W3165839861 hasAuthorship W3165839861A5015381800 @default.
• W3165839861 hasAuthorship W3165839861A5024292276 @default.
• W3165839861 hasAuthorship W3165839861A5026102133 @default.
• W3165839861 hasAuthorship W3165839861A5034559392 @default.
• W3165839861 hasAuthorship W3165839861A5036815852 @default.
• W3165839861 hasAuthorship W3165839861A5058026179 @default.
• W3165839861 hasBestOaLocation W31658398611 @default.
• W3165839861 hasConcept C126322002 @default.
• W3165839861 hasConcept C203014093 @default.
• W3165839861 hasConcept C2522874641 @default.
• W3165839861 hasConcept C2776408679 @default.
• W3165839861 hasConcept C2777214474 @default.
• W3165839861 hasConcept C2777377203 @default.
• W3165839861 hasConcept C2778019345 @default.
• W3165839861 hasConcept C2778902805 @default.
• W3165839861 hasConcept C41260117 @default.
• W3165839861 hasConcept C71924100 @default.
• W3165839861 hasConcept C90924648 @default.
• W3165839861 hasConceptScore W3165839861C126322002 @default.
• W3165839861 hasConceptScore W3165839861C203014093 @default.
• W3165839861 hasConceptScore W3165839861C2522874641 @default.
• W3165839861 hasConceptScore W3165839861C2776408679 @default.
• W3165839861 hasConceptScore W3165839861C2777214474 @default.
• W3165839861 hasConceptScore W3165839861C2777377203 @default.
• W3165839861 hasConceptScore W3165839861C2778019345 @default.
• W3165839861 hasConceptScore W3165839861C2778902805 @default.
• W3165839861 hasConceptScore W3165839861C41260117 @default.
• W3165839861 hasConceptScore W3165839861C71924100 @default.
• W3165839861 hasConceptScore W3165839861C90924648 @default.
• W3165839861 hasIssue "1" @default.
• W3165839861 hasLocation W31658398611 @default.
• W3165839861 hasOpenAccess W3165839861 @default.
• W3165839861 hasPrimaryLocation W31658398611 @default.
• W3165839861 hasRelatedWork W125090411 @default.
• W3165839861 hasRelatedWork W1965958392 @default.
• W3165839861 hasRelatedWork W2008626862 @default.
• W3165839861 hasRelatedWork W2021351004 @default.
• W3165839861 hasRelatedWork W2082248920 @default.
• W3165839861 hasRelatedWork W2898316466 @default.
• W3165839861 hasRelatedWork W2941199578 @default.
• W3165839861 hasRelatedWork W2987159879 @default.
• W3165839861 hasRelatedWork W3042601109 @default.
• W3165839861 hasRelatedWork W4210912349 @default.
• W3165839861 hasVolume "11" @default.
• W3165839861 isParatext "false" @default.
• W3165839861 isRetracted "false" @default.
• W3165839861 magId "3165839861" @default.
• W3165839861 workType "article" @default.