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- W3165858085 startingPage "101372" @default.
- W3165858085 abstract "Our incomplete understanding of the link between Alzheimer’s Disease pathology and symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies have begun to connect the dots between protein alterations and deposition, brain network dysfunction and cognitive deficits. Disturbance of neuronal activity, and in particular an imbalance in underlying excitation/inhibition (E/I), appears early in AD, and can be regarded as forming a central link between structural brain pathology and cognitive dysfunction. While there are emerging (non-)pharmacological options to influence this imbalance, the complexity of human brain dynamics has hindered identification of an optimal approach. We suggest that focusing on the integration of neurophysiological aspects of AD at the micro-, meso- and macroscale, with the support of computational network modeling, can unite fundamental and clinical knowledge, provide a general framework, and suggest rational therapeutic targets." @default.
- W3165858085 created "2021-06-07" @default.
- W3165858085 creator A5002029161 @default.
- W3165858085 creator A5040552736 @default.
- W3165858085 creator A5043644825 @default.
- W3165858085 creator A5061323918 @default.
- W3165858085 date "2021-08-01" @default.
- W3165858085 modified "2023-10-12" @default.
- W3165858085 title "Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology" @default.
- W3165858085 cites W1073194301 @default.
- W3165858085 cites W1510314685 @default.
- W3165858085 cites W1514559719 @default.
- W3165858085 cites W1532567876 @default.
- W3165858085 cites W1603307924 @default.
- W3165858085 cites W1662469265 @default.
- W3165858085 cites W1874656956 @default.
- W3165858085 cites W1914540552 @default.
- W3165858085 cites W1915842929 @default.
- W3165858085 cites W1927567505 @default.
- W3165858085 cites W1963862400 @default.
- W3165858085 cites W1967823816 @default.
- W3165858085 cites W1970910654 @default.
- W3165858085 cites W1973198655 @default.
- W3165858085 cites W1973780704 @default.
- W3165858085 cites W1981271931 @default.
- W3165858085 cites W1984652813 @default.
- W3165858085 cites W1984881525 @default.
- W3165858085 cites W1985220467 @default.
- W3165858085 cites W1988075797 @default.
- W3165858085 cites W1990897082 @default.
- W3165858085 cites W2004852048 @default.
- W3165858085 cites W2022381144 @default.
- W3165858085 cites W2025323112 @default.
- W3165858085 cites W2027430739 @default.
- W3165858085 cites W2027704676 @default.
- W3165858085 cites W2029371901 @default.
- W3165858085 cites W2034147064 @default.
- W3165858085 cites W2035466313 @default.
- W3165858085 cites W2035902012 @default.
- W3165858085 cites W2036755018 @default.
- W3165858085 cites W2040628961 @default.
- W3165858085 cites W2041537613 @default.
- W3165858085 cites W2043430884 @default.
- W3165858085 cites W2043948388 @default.
- W3165858085 cites W2047679742 @default.
- W3165858085 cites W2051303822 @default.
- W3165858085 cites W2052742260 @default.
- W3165858085 cites W2056716587 @default.
- W3165858085 cites W2057070604 @default.
- W3165858085 cites W2057178460 @default.
- W3165858085 cites W2060351135 @default.
- W3165858085 cites W2061837100 @default.
- W3165858085 cites W2062605351 @default.
- W3165858085 cites W2063497316 @default.
- W3165858085 cites W2072292615 @default.
- W3165858085 cites W2074274706 @default.
- W3165858085 cites W2081533023 @default.
- W3165858085 cites W2087938247 @default.
- W3165858085 cites W2088905367 @default.
- W3165858085 cites W2090490936 @default.
- W3165858085 cites W2095060637 @default.
- W3165858085 cites W2096935768 @default.
- W3165858085 cites W2101232028 @default.
- W3165858085 cites W2104731571 @default.
- W3165858085 cites W2105504969 @default.
- W3165858085 cites W2109036371 @default.
- W3165858085 cites W2109807300 @default.
- W3165858085 cites W2112599260 @default.
- W3165858085 cites W2116083905 @default.
- W3165858085 cites W2121418448 @default.
- W3165858085 cites W2124443688 @default.
- W3165858085 cites W2126650951 @default.
- W3165858085 cites W2134494361 @default.
- W3165858085 cites W2142875089 @default.
- W3165858085 cites W2146052710 @default.
- W3165858085 cites W2147435466 @default.
- W3165858085 cites W2153628730 @default.
- W3165858085 cites W2160941826 @default.
- W3165858085 cites W2167922559 @default.
- W3165858085 cites W2168312889 @default.
- W3165858085 cites W2168334242 @default.
- W3165858085 cites W2168489336 @default.
- W3165858085 cites W2168720199 @default.
- W3165858085 cites W2180397831 @default.
- W3165858085 cites W2202665792 @default.
- W3165858085 cites W2216098159 @default.
- W3165858085 cites W2220400500 @default.
- W3165858085 cites W2305929847 @default.
- W3165858085 cites W2314634699 @default.
- W3165858085 cites W2341046893 @default.
- W3165858085 cites W2474977510 @default.
- W3165858085 cites W2510053021 @default.
- W3165858085 cites W2519528771 @default.
- W3165858085 cites W2527558243 @default.
- W3165858085 cites W2549366107 @default.
- W3165858085 cites W2549648512 @default.
- W3165858085 cites W2556389549 @default.
- W3165858085 cites W2590144118 @default.